Article
Medicine, Research & Experimental
Di Wu, Anliang Xia, Tianlong Fan, Guoqiang Li
Summary: This study identified circRASGRF2 as significantly upregulated in HCC tissues and cell lines, promoting proliferation and migration of liver cancer cells by sponging miR-1224. Mechanistically, circRASGRF2 was found to enhance the expression of focal adhesion kinase (FAK) in HCC. These findings suggest circRASGRF2 as a central component linking circRNAs to HCC progression, making it a potential therapeutic target.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Yu Zhang, Ying Zhong, Shaoyu Guo, Yefei Zhu, Jing Guo, Yuanshuai Fu, Mingyou Li
Summary: This study identified a large number of circRNAs in the ovaries and testes of medaka through RNA sequencing, with some circRNAs showing significant differential expression between the testis and ovary. Experimental validation confirmed that a subset of circRNAs can interact with miRNAs and are expressed in reproductive cells.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Biochemical Research Methods
Marieke Vromman, Jasper Anckaert, Stefania Bortoluzzi, Alessia Buratin, Chia-Ying Chen, Qinjie Chu, Trees-Juen Chuang, Roozbeh Dehghannasiri, Christoph Dieterich, Xin Dong, Paul Flicek, Enrico Gaffo, Wanjun Gu, Chunjiang He, Steve Hoffmann, Osagie Izuogu, Michael S. Jackson, Tobias Jakobi, Eric C. Lai, Justine Nuytens, Julia Salzman, Mauro Santibanez-Koref, Peter Stadler, Olivier Thas, Eveline Vanden Eynde, Kimberly Verniers, Guoxia Wen, Jakub Westholm, Li Yang, Chu-Yu Ye, Nurten Yigit, Guo-Hua Yuan, Jinyang Zhang, Fangqing Zhao, Jo Vandesompele, Pieter-Jan Volders
Summary: This study evaluates and validates computational tools for detecting circRNAs, finding most tools to be highly precise with variations in sensitivity and total detection.
Review
Oncology
Maria Radanova, Galya Mihaylova, Neshe Nazifova-Tasinova, Mariya Levkova, Oskan Tasinov, Desislava Ivanova, Zhasmina Mihaylova, Ivan Donev
Summary: Recent studies have highlighted the potential of circRNAs as new diagnostic and prognostic biomarkers in colorectal cancer (CRC), with a focus on their clinical significance and diagnostic potential. The reliability of circRNAs as non-invasive biomarkers and the challenges of finding more reliable biomarkers for early diagnosis and predicting metastasis and resistance to therapies have been discussed. There is a growing understanding of the role of oncogenic circRNAs in CRC pathogenesis and the potential for using them as new drug targets in personalized treatment.
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Genetics & Heredity
Maedeh Bagheri Moghaddam, Majid Maleki, Maziar Oveisee, Mahrokh Bagheri Moghaddam, Maedeh Arabian, Mahshid Malakootian
Summary: Cardiomyopathies are a group of cardiac diseases that lead to heart failure and mortality. Circular RNAs, a novel type of noncoding RNAs with unique structure, have been found to play significant roles in cardiomyopathies and have potential clinical applications.
Review
Cell Biology
Jun Wu, Xin Guo, Yi Wen, Shangqing Huang, Xiaohui Yuan, Lijun Tang, Hongyu Sun
Summary: m6A modification is widely present in circRNAs, playing key biological functions. By regulating circRNAs, m6A modification plays important roles in immunity and various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Min-Cheng Yu, Guang-Yu Ding, Peng Ma, Yue-Da Chen, Xiao-Dong Zhu, Jia-Bin Cai, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ming Kuang, Cheng Huang
Summary: CircUBAP2 is highly upregulated in hepatocellular carcinoma, promoting growth and metastasis, and may serve as an independent prognostic biomarker or therapeutic target for HCC.
Review
Biochemistry & Molecular Biology
Xiaozhu Tang, Hongyan Ren, Mengjie Guo, Jinjun Qian, Ye Yang, Chunyan Gu
Summary: circRNAs are a class of interesting and conserved single-stranded RNA molecules that play important roles in various biological processes, especially in microRNA sponges, gene splicing and transcription regulation, RNA-binding protein sponges, and protein/peptide translation. They are involved in various human diseases, particularly cancers, and may serve as better predictive biomarkers and therapeutic targets for cancer treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Yitao He, Hui Zhang, Jian Deng, Zhili Cai, Mei Gu, Chenyong Zhao, Yi Guo
Summary: This study aimed to investigate the functions of fluoxetine and identification of fluoxetine-mediated circRNAs and mRNAs in cerebral ischemic stroke. Results showed that fluoxetine significantly reduced cerebral infarction area in rats after MCAO, and differentially expressed circRNAs and mRNAs were identified. The circMap2k1/miR-135b-5p/Pidd1 axis may potentially be involved in cerebral ischemic stroke.
Article
Oncology
Mei Mei, Yingjun Wang, Wenting Song, Zhaoming Li, Qilong Wang, Jiayin Li, Mingzhi Zhang
Summary: The study found that circADARB1 was highly expressed in the plasma of NKTCL patients. Knockdown of circADARB1 inhibited proliferation of NKTCL cells and it bound to miR-214-3p to regulate the expression of p-Stat3.
CANCER CELL INTERNATIONAL
(2021)
Article
Agriculture, Multidisciplinary
Ao Qi, Wenxiu Ru, Haiyan Yang, Yu Yang, Jia Tang, Shuling Yang, Xianyong Lan, Chuzhao Lei, Xiuzhu Sun, Hong Chen
Summary: This study showed that circACTA1 regulates the multiplication, apoptosis, and cytodifferentiation of bovine myocytes by activating the MAP3K11/MAP2K7/JNK signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Pathology
Sen Liu, Xiang Yu Guo, Qing Juan Shang, Peng Gao
Summary: Circular RNAs are covalently closed and non-coding molecules in eukaryotes. They exhibit tissue-specific and temporal expression patterns, regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm and exert biological functions through complementary base pairing, regulation of protein function, or self-translation. Recent studies have shown the impact of N6-Methyladenosine (m6A), a prevalent post-transcriptional modification, on the translation, localization, and degradation of circular RNAs. The development of high-throughput sequencing technology and novel research methods has greatly advanced circular RNA research.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Review
Pharmacology & Pharmacy
Min Zhou, Xianling Gao, Xin Zheng, Jing Luo
Summary: This review focuses on the mechanisms, role, and clinical significance of circular RNAs (circRNAs) in acute myeloid leukemia (AML). Although significant progress has been made, further research is needed to explore other mechanisms, the machinery regulating circRNA fate, downstream effectors of circRNA modulatory networks, and the clinical application of circRNAs in AML.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jialei Li, Yu Han, Shuang Wang, Xiaolei Wu, Jimin Cao, Teng Sun
Summary: Non-coding RNAs, specifically microRNAs, long non-coding RNAs, and circular RNAs, play important roles in cardiac function modulation and heart diseases. While microRNAs and long non-coding RNAs have been extensively studied, the characteristics of circular RNAs have been less explored. This review focuses on the biogenesis, biological functions, and latest research on various circRNAs related to myocardial infarction, highlighting their potential as new therapies and biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Pei Du, Chensi Miao, Qiuli Lou, Zefeng Wang, Chunbo Lou
ACS SYNTHETIC BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Yue Sun, Yufang Bao, Wenjian Han, Fan Song, Xianfeng Shen, Jiawei Zhao, Ji Zuo, David Saffen, Wei Chen, Zefeng Wang, Xintian You, Yongbo Wang
NUCLEIC ACIDS RESEARCH
(2017)
Article
Multidisciplinary Sciences
Huan-Huan Wei, Yuanlong Liu, Yang Wang, Qianyun Lu, Xuerong Yang, Jiefu Li, Zefeng Wang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Biochemistry & Molecular Biology
Yang-Yang Zhao, Miao-Wei Mao, Wen-Jing Zhang, Jue Wang, Hai-Tao Li, Yi Yang, Zefeng Wang, Jia-Wei Wu
NUCLEIC ACIDS RESEARCH
(2018)
Review
Cell Biology
Xiaowei Song, Zhenyu Zeng, Huanhuan Wei, Zefeng Wang
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miaowei Mao, Yue Hu, Yun Yang, Yajie Qian, Huanhuan Wei, Wei Fan, Yi Yang, Xiaoling Li, Zefeng Wang
Article
Multidisciplinary Sciences
Xiaojuan Fan, Yun Yang, Chuyun Chen, Zefeng Wang
Summary: Circular RNAs (circRNAs) have been found to be translated through IRES-driven mechanism. Short elements that drive circRNA translation have been identified, suggesting a pervasive cap-independent translation in the human transcriptome.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenjian Han, Wendi Huang, Tong Wei, Yanwen Ye, Miaowei Mao, Zefeng Wang
Summary: This study reports a new RNA editing system that allows precise gene editing using a single engineered protein, without the need for auxiliary RNA. The system achieves high editing efficiency and low off-target effects, making it applicable for correcting disease-associated gene mutations.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Yufang Bao, Sirui Zhang, Xiaoyu Zhang, Yunjian Pan, Yueren Yan, Ning Wang, Yunpeng Ren, Ji Zuo, Wei-Xing Zong, Zefeng Wang, Yongbo Wang
Summary: Loss-of-function mutations in RBM10 frequently co-occur with oncogenic EGFR mutations in lung adenocarcinoma (LUAD). Understanding the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could lead to more effective treatment strategies.
Article
Multidisciplinary Sciences
Miaowei Mao, Yajie Qian, Wenyao Zhang, Siyu Zhou, Zefeng Wang, Xianjun Chen, Yi Yang
Summary: In this study, a stable monomeric tag (SULI) based on a single light-oxygen-voltage domain from Neurospora crassa was engineered for yeast and zebrafish. SULI allows control of protein stability by inducing degradation in dark conditions and provides spatiotemporal modulation of protein levels.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Ning Wang, Yue Hu, Zefeng Wang
Summary: Eukaryotic gene expression is tightly regulated at multiple levels, including alternative splicing, which generates multiple mRNA isoforms from a single gene. Epigenetic modifications play crucial roles in the regulation of alternative splicing by affecting transcription, splicing factor recruitment, and splicing factor expression/activity. Dysregulation of epigenetics and splicing is common in cancer and can have functional consequences. Understanding the complex regulation of gene expression layers can provide new insights into modulating disease-related splicing dysregulation.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biochemistry & Molecular Biology
Li Wang, John A. Wrobel, Ling Xie, DongXu Li, Giada Zurlo, Huali Shen, Pengyuan Yang, Zefeng Wang, Yibing Peng, Harsha P. Gunawardena, Qing Zhang, Xian Chen
CELL CHEMICAL BIOLOGY
(2018)
Article
Biochemical Research Methods
Yun Yang, Zefeng Wang
CIRCULAR RNAS: METHODS AND PROTOCOLS
(2018)
Article
Cell Biology
Yun Yang, Xiaojuan Fan, Miaowei Mao, Xiaowei Song, Ping Wu, Yang Zhang, Yongfeng Jin, Yi Yang, Ling-Ling Chen, Yang Wang, Catherine C. L. Wong, Xinshu Xiao, Zefeng Wang
Article
Cell Biology
Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C. L. Wong, Ronggui Hu, Jingyi Hui
