Article
Oncology
Jingrong Xian, Shiwen Wang, Yanyu Jiang, Lihui Li, Lili Cai, Ping Chen, Yue Liu, Xiaofei Zeng, Guoan Chen, Chen Ding, Robert M. Hoffman, Lijun Jia, Hu Zhao, Yanmei Zhang
Summary: This study found that NEDD8 is upregulated in ESCC and is associated with poorer patient survival. Downregulation of NEDD8 suppresses tumor growth and induces cell cycle arrest, DNA damage, and apoptosis in ESCC. The mechanism involves the accumulation of CRLs substrates, which can be attenuated by knockdown of DR5.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yu-Chuan Lin, Chun-Hung Hua, Hsin-Man Lu, Shi-Wei Huang, Yeh Chen, Ming-Hsui Tsai, Fang-Yu Lin, Peter Canoll, Shao-Chih Chiu, Wei-Hua Huang, Der-Yang Cho, Chia-Ing Jan
Summary: This study investigates the regulation of HLA-G expression through NLRP3 inflammasome-mediated IL-1 beta secretion in OSCC. The upregulation of NLRP3 inflammasome leads to abundant HLA-G in FaDu cells, and anti-HLA-G CAR-T cells show therapeutic effects in EGFR-mutated and overexpressed oral cancer.
Article
Biology
Jee Soo Park, Myung Eun Lee, Seung Hwan Kim, Won Sik Jang, Won Sik Ham
Summary: The study developed a novel murine RCC model for studying pulmonary metastasis. By implanting cells and monitoring metastasis in mice, the model consistently and efficiently recapitulated RCC pulmonary metastasis, allowing for the elucidation of molecular mechanisms and evaluation of therapeutic modalities.
Review
Pharmacology & Pharmacy
Sau Har Lee, Brianna Brianna
Summary: This review aims to shed light on the role of overexpressed miRNAs in cancer progression and explores the potential of antisense miRNAs in cancer treatment.
CURRENT DRUG TARGETS
(2022)
Review
Oncology
Javier Torres-Jimenez, Jorge Esteban-Villarrubia, Reyes Ferreiro-Monteagudo
Summary: Colorectal cancer is the third most common cancer in Europe and is treated with chemotherapy, anti-VEGF, and anti-EGFR therapies. However, there is currently no approved ERBB2-targeted therapy for metastatic CRC.
Article
Medicine, Research & Experimental
Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Jiansong Ji
Summary: This study demonstrated that overexpression of FGFR1 and its downstream AKT/mTOR and ERK signaling activation could induce lenvatinib resistance in hepatocellular carcinoma. Both in vivo and in vitro results showed that Oxysophocarpine inhibited the proliferation and induced apoptosis of FGFR1-overexpressed HCC cells, sensitizing them to lenvatinib treatment. Mechanism studies indicated that Oxysophocarpine downregulated FGFR1 expression and its downstream signaling pathways, enhancing the effectiveness of lenvatinib in FGFR1-overexpressed HCC.
Article
Cell Biology
Yang Shi, Zheng Xiang, Huiyu Yang, Suliman Khan, Ruizhe Li, Siran Zhou, Saif Ullah, Jiyu Zhang, Bingrong Liu
Summary: The study demonstrated the treatment response of esophageal squamous cell carcinoma (ESCC) to selective histone deacetylase inhibitor (HDACi) LMK-235 and identified TNS3 as a potential biomarker predicting treatment sensitivity. TNS3, highly expressed in ESCC, was found to be down-regulated in response to LMK-235 treatment and correlated with tumor malignancy and poor prognosis. Silencing TNS3 inhibited ESCC cell proliferation and sensitized the treatment response to LMK-235, providing insights into its oncogenic role in ESCC and clinical application for HDAC targeted therapy.
Article
Chemistry, Multidisciplinary
Jing Zhang, Lulu Han, Haigang Wu, Yong Zhong, Shangguan Ping, Yisheng Liu, Mu He, Han Sun, Chenhui Song, Xin Wang, Yang Liu, Jiefei Wang, Lei Zheng, Bingyang Shi, Ben Zhong Tang
Summary: Au(I)-based NIR-II ferroptosis activators show potential in in vivo theranostics of deep tumors, but nonvisual systems and nonspecific activations can have detrimental effects. In this study, Au(I)-based NIR-II ferroptosis nanoparticles were ingeniously constructed for brain-targeted orthotopic glioblastoma theranostics. Real-time visual monitoring of BBB penetration and glioblastoma targeting was achieved, and the release of TBTP-Au specifically activated effective ferroptosis in glioma cells, leading to extended survival time in mice. This new mechanism may pave the way for the development of high-specificity visual anticancer drugs.
Article
Multidisciplinary Sciences
Wei Liu, Lei Xie, Yao-Hui He, Zhi-Yong Wu, Lu-Xin Liu, Xue-Feng Bai, Dan-Xia Deng, Xiu-E Xu, Lian-Di Liao, Wan Lin, Jing-Hua Heng, Xin Xu, Liu Peng, Qing-Feng Huang, Cheng-Yu Li, Zhi-Da Zhang, Wei Wang, Guo-Rui Zhang, Xiang Gao, Shao-Hong Wang, Chun-Quan Li, Li-Yan Xu, Wen Liu, En-Min Li
Summary: Proteomic analysis identified two molecular subtypes of esophageal cancer, with the S2 subtype being more aggressive and associated with a potential therapeutic outlook provided by a subtype diagnostic and prognostic model.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Rhynelle S. Dmello, Sarah Q. To, Ashwini L. Chand
Summary: Liver metastasis is a significant factor in the mortality of colorectal cancer patients. Understanding the cellular interactions in the tumor microenvironment can lead to the development of new therapeutic targets for metastatic colorectal cancer, despite current treatment challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Jiale Zhang, Yanxin Dong, Shouyin Di, Shun Xie, Boshi Fan, Taiqian Gong
Summary: Tumor-associated macrophages (TAMs) play a crucial role in esophageal squamous carcinoma (ESCC), influencing tumor growth, invasion, and treatment outcomes. Understanding the function of TAMs is essential for the development of innovative therapeutic strategies for ESCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Mirela-Diana Ilie, Dario De Alcubierre, Anna Lucia Carretti, Emmanuel Jouanneau, Gerald Raverot
Summary: The complex tumor microenvironment (TME) has become an increasingly important target for cancer treatment. This study examined the use of immune-checkpoint inhibitors and anti-angiogenic drugs in treating aggressive pituitary tumors and pituitary carcinomas, reporting tumor response rates, potential predictors of response, and adverse events. The study found that the tumor type was the strongest predictor of response to immune-checkpoint inhibitors, while no predictors of response to anti-angiogenic drugs have been identified. The study also discussed the potential of TME-targeting strategies, including immunotherapy and targeting other TME components.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Pan Gao, Hongtao Liu, Zhenzhen Yang, Yiran Hui, Zhuangzhuang Shi, Zhen Yang, Min Song, Menghui Yao, Wenfei Fan, Jinhua Yang, Yibin Hao, Tianli Fan
Summary: This study successfully established a highly invasive EC9706-I-3 cell line as a metastatic model for ESCC, demonstrating rapid proliferation and high invasion capabilities, as well as insensitivity to the chemotherapy drug 5-fluorouracil. Utilizing the renal capsule model and live animal imaging system, it confirmed the advantages of the EC9706-I-3 cell line in terms of metastatic rate and tumor growth rate.
ONCOTARGETS AND THERAPY
(2021)
Review
Oncology
Yang Shi, Meiqi Wang, Dan Liu, Saif Ullah, Xing Ma, Huiyu Yang, Bingrong Liu
Summary: Esophageal carcinoma tumorigenesis is linked to transcriptional dysregulation and dependency on specific regulators of gene expression, particularly the larger non-coding cis-regulatory elements known as super-enhancers (SEs). Targeting the transcriptional addictions driven by SEs could offer potential opportunities for molecular treatments on esophageal carcinoma and other cancer types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yanfeng Dai, Xiang Yu, Yuehong Leng, Xingzhou Peng, Junjie Wang, Yifan Zhao, Juan Chen, Zhihong Zhang
Summary: We report a melittin-loaded and hyaluronic acid (HA)-conjugated high-density lipoprotein (HDL) mimic phospholipid scaffold nanoparticle (MLT-HA-HPPS) that targets both breast cancer and its metastasis to lymph nodes. This nanoparticle effectively delivers the melittin peptide to breast cancer cells and inhibits their growth. Moreover, the delivery of MLT-HA-HPPS to lymph nodes can be monitored by NIR fluorescence imaging, which is beneficial for prognosis and treatment of lymph node metastasis in breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pediatrics
Viktoria Amanda Pfeifle, Stephanie J. Gros, Giovanni Frongia, Karl-Herbert Schaefer, Stefan Holland-Cunz
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2017)
Letter
Allergy
Lucy Sucic, Virginie Galati-Fournier, Urs Kym, Viktoria A. Pfeifle, Stephanie J. Gros, Karl-Herbert Schaefer, Stefan Holland-Cunz, Simone Keck
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Astrid Drenckhan, Morton Freytag, Claudiu T. Supuran, Guido Sauter, Jakob R. Izbicki, Stephanie J. Gros
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Stephanie J. Gros, Stefan G. Holland-Cunz, Claudiu T. Supuran, Olivier Braissant
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Pediatrics
Nicola Pini, Zihe Huo, Urs Kym, Stefan Holland-Cunz, Stephanie J. Gros
Summary: Neuroblastoma is a highly heterogeneous tumor with various adverse factors linked to its oncogenesis, progression, and metastases. The expression of AQP1 in neuroblastoma correlates with changing cellular factors, particularly hypoxic status, NMYC and NCAM expression. Additionally, AQP1 expression is associated with increased migratory behavior of neuroblastoma cells under hypoxic conditions.
Article
Cell Biology
Zihe Huo, Mihai Lomora, Urs Kym, Cornelia Palivan, Stefan G. Holland-Cunz, Stephanie J. Gros
Summary: It was found that AQP1 expression in neuroblastoma cells is up-regulated under hypoxic conditions, and increased AQP1 expression enables cells to form a phenotype associated with migration and increased cell agility. This implies that the hypoxic tumor microenvironment may trigger some tumor cells to transition to a migratory phenotype.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zihe Huo, Mariana Sa Santos, Astrid Drenckhan, Stefan Holland-Cunz, Jakob R. Izbicki, Michael A. Nash, Stephanie J. Gros
Summary: This study investigated thermogenic activity and adhesion strength of patient-derived metastatic esophageal tumor cells, and found that metastatic cells have higher thermogenic profile and decreased adhesion strength, which are associated with a higher metastatic potential.
Article
Pediatrics
J. L. Muff, L. C. Guglielmetti, S. J. Gros, L. Buchmueller, G. Frongia, S. G. Holland-Cunz, T. de Trey, Raphael N. Vuille-Dit-Bille
Summary: The study found that failed preoperative vacuum bell therapy had minimal to no effect on short-term outcomes and long-term perceptions following minimally invasive repair of pectus excavatum. Preoperative vacuum bell treatment did not significantly impact outcomes such as length of hospital stay, postoperative complications, and bar dislocations.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Article
Pediatrics
Nora Manz, Claudia Hoefele-Behrendt, Julia Bielicki, Hanna Schmid, Matthias S. Matter, Isabella Bielicki, Stefan Holland-Cunz, Stephanie J. Gros
Summary: This study presents the clinical course of three children with MIS-C who underwent surgery due to abdominal symptoms. Following elevated inflammatory markers, the patients were reevaluated and treated with corticosteroids, intravenous immunoglobulins, aspirin, and/or heparin. It stresses the importance of assessing medical history and monitoring the clinical course in MIS-C patients.
Article
Pediatrics
Nicola Pini, Zihe Huo, Stefan Holland-Cunz, Stephanie J. Gros
Summary: Neuroblastoma cells have an increased energy demand, and adding glucose or fructose stimulates their metabolic activity. Fructose has a greater impact on cell proliferation, leading to enhanced thermogenic activity.
Article
Pediatrics
Alexander Kapp, David Troxler, Friederike Prufer, Stefan Holland-Cunz, Martina Frech, Stephanie J. Gros
Summary: Testicular torsion is a surgical emergency that requires early diagnosis and treatment to preserve the affected gonad. While severe, persistent, unilateral scrotal pain is typically emphasized as a cardinal symptom of this condition, cases with minimal pain may also occur. Prompt diagnosis and surgical intervention are crucial in salvaging the affected testicle.
Article
Pediatrics
Vivienne Sommer-Joergensen, Jelena Sarcevic, Frank-Martin Haecker, Stefan Holland-Cunz, Stephanie J. Gros, Martina Frech-Doerfler
Summary: This study aimed to evaluate the value of DVAISS in voiding abnormalities in children and adolescents. The results showed that DVAISS could predict the clinical course and treatment duration, and it is an important tool for assessing the severity of the disease and predicting the time needed for symptom resolution.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Zihe Huo, Remo Bilang, Claudiu T. Supuran, Nicolas von Der Weid, Elisabeth Bruder, Stefan Holland-Cunz, Ivan Martin, Manuele G. Muraro, Stephanie J. Gros
Summary: This study proposes a new patient-derived 3D slice-culture perfusion-based model for neuroblastoma treatment evaluation, combined with isothermal microcalorimetry. The use of the novel carbonic anhydrase IX and XII (CAIX/CAXII) inhibitor SLC-0111 showed promising results in reducing cell viability and thermogenesis in neuroblastoma cells. The perfusion-based bioreactor system allowed for the evaluation of drug response with intact tumor cells and stromal structure for up to 7 days. This approach can facilitate the development of personalized treatment strategies for neuroblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Stefanie Volkart, Urs Kym, Olivier Braissant, Edgar Delgado-Eckert, Samer Al-Samir, Rebecca Angresius, Zihe Huo, Stefan Holland-Cunz, Stephanie J. J. Gros
Summary: This study analyzed the distribution and localization of AQP1 in the entire intestinal tract of mice. A specific pattern of AQP1 expression was found throughout the gastrointestinal tract. AQP1 expression correlated with the expression profiles of hypoxia-dependent proteins and was associated with changes in intestinal wall anatomy and bacterial stool microbiome composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Pediatrics
J. L. Muff, L. C. Guglielmetti, S. J. Gros, L. Buchmuller, G. Frongia, F. -m. Haecker, S. G. Holland-Cunz, T. de Trey, Raphael N. Vuille-dit-Bille
PEDIATRIC SURGERY INTERNATIONAL
(2022)
