Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer
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Title
Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 4, Pages 2067
Publisher
MDPI AG
Online
2021-02-20
DOI
10.3390/ijms22042067
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Note: Only part of the references are listed.- Regorafenib in Chinese patients with metastatic colorectal cancer: Subgroup analysis of the phase 3 CONCUR trial
- (2020) Jianming Xu et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Annual report to the nation on the status of cancer, part I: National cancer statistics
- (2020) S. Jane Henley et al. CANCER
- Annual report to the nation on the status of cancer, part II: Progress toward Healthy People 2020 objectives for 4 common cancers
- (2020) S. Jane Henley et al. CANCER
- Cancer, COVID-19 and the precautionary principle: prioritizing treatment during a global pandemic
- (2020) Timothy P. Hanna et al. Nature Reviews Clinical Oncology
- Impact of COVID-19 on colorectal cancer disparities and the way forward
- (2020) Sophie Balzora et al. GASTROINTESTINAL ENDOSCOPY
- The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study
- (2020) Camille Maringe et al. LANCET ONCOLOGY
- Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments
- (2020) Marcos V. Perini et al. PHARMACOLOGY & THERAPEUTICS
- WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases
- (2020) Fengbo Tan et al. Cancer Management and Research
- Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
- (2020) Thierry André et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hepatocytes direct the formation of a pro-metastatic niche in the liver
- (2019) Jae W. Lee et al. NATURE
- Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial
- (2019) Salah-Eddin Al-Batran et al. LANCET
- Interactions in the (Pre)metastatic Niche Support Metastasis Formation
- (2019) Ginevra Doglioni et al. Frontiers in Oncology
- Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
- (2019) Man-Tzu Wang et al. Nature Communications
- Global patterns and trends in colorectal cancer incidence in young adults
- (2019) Rebecca L Siegel et al. GUT
- Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
- (2019) NaNa Keum et al. Nature Reviews Gastroenterology & Hepatology
- The Role Of Hepatic Stellate Cells In Promoting Liver Metastasis Of Colorectal Carcinoma
- (2019) Wen-Hai Huang et al. OncoTargets and Therapy
- IL6 modulates the immune status of the tumor microenvironment to facilitate metastatic colonization of colorectal cancer cells
- (2019) Yujiro Toyoshima et al. Cancer Immunology Research
- The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
- (2019) Jill Hallin et al. Cancer Discovery
- Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
- (2019) Aitor Benedicto et al. Scientific Reports
- CXCR4/TGF-β1 mediated hepatic stellate cells differentiation into carcinoma-associated fibroblasts and promoted liver metastasis of colon cancer
- (2019) Hao-Xiang Tan et al. CANCER BIOLOGY & THERAPY
- Synchronous and metachronous liver metastases in patients with colorectal cancer—towards a clinically relevant definition
- (2019) Jennie Engstrand et al. World Journal of Surgical Oncology
- Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO
- (2018) C Cremolini et al. ANNALS OF ONCOLOGY
- The role of hepatic macrophages in liver metastasis
- (2018) Jiri Keirsse et al. CELLULAR IMMUNOLOGY
- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities
- (2018) Wei Wang et al. SEMINARS IN CANCER BIOLOGY
- Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling
- (2018) Xiaochao Zhang et al. Cell Death & Disease
- The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment
- (2018) Daniëlle G. Leuning et al. Scientific Reports
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis
- (2018) Yingkuan Shao et al. CARCINOGENESIS
- Identification of the tumour transition states occurring during EMT
- (2018) Ievgenia Pastushenko et al. NATURE
- Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single‐Arm, Open‐Label Phase IIIb CONSIGN Study
- (2018) Eric Van Cutsem et al. ONCOLOGIST
- The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients
- (2018) Marc Van den Eynde et al. CANCER CELL
- Trends in Colon and Rectal Cancer Incidence in Australia from 1982 to 2014: Analysis of Data on Over 375,000 Cases
- (2018) Eleonora Feletto et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases
- (2018) Ovidiu Balacescu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
- (2018) Zhicheng Zeng et al. Nature Communications
- Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma
- (2017) Wantae Kim et al. GUT
- Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis
- (2017) Takahiro Tsujikawa et al. Cell Reports
- Subgroup analysis in RAISE: a randomized, double-blind phase III study of irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) plus ramucirumab or placebo in patients with metastatic colorectal carcinoma progression
- (2016) R. Obermannová et al. ANNALS OF ONCOLOGY
- Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches
- (2016) P. Brodt CLINICAL CANCER RESEARCH
- Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy
- (2016) Etienne Becht et al. CLINICAL CANCER RESEARCH
- YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling
- (2016) Ralph Gruber et al. GASTROENTEROLOGY
- Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
- (2016) Bernhard Mlecnik et al. IMMUNITY
- Metastatic colonization by circulating tumour cells
- (2016) Joan Massagué et al. NATURE
- The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis
- (2016) Bernhard Mlecnik et al. Science Translational Medicine
- Role of First-Line Anti–Epidermal Growth Factor Receptor Therapy Compared With Anti–Vascular Endothelial Growth Factor Therapy in Advanced Colorectal Cancer: A Meta-Analysis of Randomized Clinical Trials
- (2015) Muhammad A. Khattak et al. Clinical Colorectal Cancer
- Cancer Incidence in Five Continents: Inclusion criteria, highlights from Volume X and the global status of cancer registration
- (2015) F. Bray et al. INTERNATIONAL JOURNAL OF CANCER
- Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment andRASMutations in Colorectal Cancer
- (2015) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Premetastatic niche formation in the liver: emerging mechanisms and mouse models
- (2015) Achim Krüger JOURNAL OF MOLECULAR MEDICINE-JMM
- When less is more: maintenance therapy in colorectal cancer
- (2015) Joleen M Hubbard et al. LANCET
- Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial
- (2015) Christophe Tournigand et al. LANCET ONCOLOGY
- Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study
- (2015) Josep Tabernero et al. LANCET ONCOLOGY
- Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
- (2015) Bruno Costa-Silva et al. NATURE CELL BIOLOGY
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Hepatic metastatic niche: from normal to pre-metastatic and metastatic niche
- (2015) Shirin Azizidoost et al. TUMOR BIOLOGY
- MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis
- (2015) Chun-Ting Hu et al. Oncotarget
- Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity
- (2014) Miranda L. Broz et al. CANCER CELL
- Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial–mesenchymal transition
- (2014) Juanjuan Ou et al. CARCINOGENESIS
- Metachronous metastases from colorectal cancer: a population-based study in North-East Netherlands
- (2014) Marloes A. G. Elferink et al. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
- Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study
- (2014) Timothy J Price et al. LANCET ONCOLOGY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer
- (2014) Fotios Loupakis et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
- (2014) Nicolas J. Llosa et al. Cancer Discovery
- EMT is the dominant program in human colon cancer
- (2013) Andre Loboda et al. BMC Medical Genomics
- The pre-metastatic niche: finding common ground
- (2013) Jaclyn Sceneay et al. CANCER AND METASTASIS REVIEWS
- Interferon-γTriggers Hepatic Stellate Cell-Mediated Immune Regulation through MEK/ERK Signaling Pathway
- (2013) Xiaodong Gu et al. Clinical & Developmental Immunology
- Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
- (2013) Gabriela Bindea et al. IMMUNITY
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
- (2012) Lauren J. Bayne et al. CANCER CELL
- Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
- (2012) Yuliya Pylayeva-Gupta et al. CANCER CELL
- Phase II Clinical and Pharmacokinetic Study of Aflibercept in Patients with Previously Treated Metastatic Colorectal Cancer
- (2012) P. A. Tang et al. CLINICAL CANCER RESEARCH
- Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
- (2012) J. S. Khalili et al. CLINICAL CANCER RESEARCH
- Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies
- (2012) Tine Jess et al. Clinical Gastroenterology and Hepatology
- Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen
- (2012) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
- (2012) Axel Grothey et al. LANCET
- Cancer stem cells and metastasis
- (2012) Katia Sampieri et al. SEMINARS IN CANCER BIOLOGY
- Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
- (2011) N. Halama et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice
- (2011) Wenxiu Zhao et al. INTERNATIONAL JOURNAL OF CANCER
- Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial
- (2011) Matthew T Seymour et al. LANCET
- Initial steps of metastasis: Cell invasion and endothelial transmigration
- (2011) Franziska van Zijl et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Worldwide Variations in Colorectal Cancer
- (2009) M. M. Center et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
- (2009) Thomas Amann et al. CANCER SCIENCE
- Tumor Self-Seeding by Circulating Cancer Cells
- (2009) Mi-Young Kim et al. CELL
- Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver
- (2009) Ekaterina Breous et al. HEPATOLOGY
- Mechanisms by which E-Selectin Regulates Diapedesis of Colon Cancer Cells under Flow Conditions
- (2008) P.-L. Tremblay et al. CANCER RESEARCH
- Origin and physiological roles of inflammation
- (2008) Ruslan Medzhitov NATURE
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