Article
Pharmacology & Pharmacy
Shuyuan Guan, Lingbin Sun, Xihua Wang, Xirui Huang, Tao Luo
Summary: Propofol can alleviate neuroinflammation and cell damage induced by lipopolysaccharide, and improve lipopolysaccharide-induced cognitive dysfunction. It exerts anti-inflammatory effects by inhibiting the metabolic reprogramming of cells via the suppression of the ROS/PI3K/Akt/mTOR/HIF-1α signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jeongmin Ha, Bum Suk Kim, Byungkuk Min, Juhyeon Nam, Jae-Geun Lee, Minhyung Lee, Byoung-Ha Yoon, Yoon Ha Choi, Ilkyun Im, Jung Sun Park, Hyosun Choi, Areum Baek, Sang Mi Cho, Mi-Ok Lee, Ki-Hoan Nam, Ji Young Mun, Mirang Kim, Seon-Young Kim, Mi Young Son, Yong-Kook Kang, Jeong-Soo Lee, Jong Kyoung Kim, Janghwan Kim
Summary: The cytoskeletal linker protein desmoplakin (Dsp) plays a crucial role in both in vitro cellular reprogramming and tissue regeneration. Knockdown of Dsp impairs the formation of intermediate cells during cellular reprogramming and tissue regeneration. This study suggests a potential evolutionary link mediated by Dsp between cellular reprogramming in mammals and tissue regeneration in lower vertebrates, and the intermediate cells may provide alternative approaches for mammalian regenerative therapy.
Article
Biochemistry & Molecular Biology
Pouria Hajmomeni, Sajjad Sisakhtnezhad, Ali Bidmeshkipour
Summary: Breast cancer, the most prevalent cancer in females, can be affected by mesenchymal stem cells (MSCs) and their paracrine effects. Thymoquinone (TQ) has various properties and affects the self-renewal and immunomodulatory properties of MSCs. The study examined the effect of TQ-treated MSC conditioned medium on the characteristics of breast cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Fu Long Nan, Wei Zheng, Wen Long Nan, Tong Yu, Chang Zhan Xie, He Zhang, Xiao Hong Xu, Cheng Hui Li, Zhuo Ha, Jin Yong Zhang, Xin Yu Zhuang, Ji Cheng Han, Wei Wang, Jing Qian, Guan Yu Zhao, Zhuo Xin Li, Jin Ying Ge, Zhi Gao Bu, Ying Zhang, Hui Jun Lu, Ning Yi Jin
Summary: This study reveals that DCs undergo phenotypic maturation but are dysfunctional in priming T cell responses during NDV infection, leading to curtailed immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Yuncong Xu, Chunhua Zhu, Yuntao Lu, Shaoqing Yang, Jing Fang, Zhengqiang Jiang
Summary: The effects of acetylated xylo-oligosaccharide (AcXOS) from Hawthorn kernels on tumor cells were evaluated. In vitro, AcXOS suppressed migration and invasion and promoted apoptosis of Hep3B and RKO tumor cells. In vivo, AcXOS inhibited xenograft tumor growth and repressed the PI3K-Akt signaling in tumors. Furthermore, AcXOS increased levels of short chain fatty acids and decreased mRNA levels of histone deacetylases in mice feces and colonic epithelial cell, respectively. These findings suggest that AcXOS from Hawthorn kernels is a potential inhibitor of tumor cells and may be used for prevention and intervention of tumor growth.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Walter Muranyi, Christian Schwerk, Rosanna Herold, Carolin Stump-Guthier, Marko Lampe, Petra Fallier-Becker, Christel Weiss, Carsten Sticht, Hiroshi Ishikawa, Horst Schroten
Summary: The choroid plexus (CP) is a vascularized structure in the ventricular system of the CNS. Immortalized CP endothelial cell lines (iHCPEnC) were generated using human telomerase reverse transcriptase (hTERT) to study the role of the fenestrated CP endothelium. iHCPEnC exhibited characteristic features and were used to establish an in vitro model with enhanced barrier function. iHCPEnC is a valuable tool for studying CP organ functions and endothelial-epithelial interactions.
Article
Oncology
Aurelie Moniot, Julien Braux, Camille Bour, Christine Guillaume, Fabien Lamret, Ingrid Allart-Simon, Sandra Audonnet, Sarah Renault, Francoise Redini, Marie Laronze-Cochard, Janos Sapi, Sophie C. Gangloff, Stephane Gerard, Frederic Velard
Summary: Novel pyridazinone derivatives have shown potential as anti-osteosarcoma therapeutics, with cytotoxic activity in vitro and the ability to limit tumor growth in a murine orthotopic osteosarcoma model. These compounds may provide a new avenue for developing therapeutic strategies against osteosarcoma.
Article
Biochemistry & Molecular Biology
Javier Perez-Duran, Aglae Luna, Andres Portilla, Pamela Martinez, Guillermo Ceballos, Miguel angel Ortiz-Flores, Juan Mario Solis-Paredes, Nayelli Najera
Summary: Breast cancer is a global public health problem, and current chemotherapy has significant adverse effects. (-)-Epicatechin (EC), a flavonoid found in plants, has been shown to have beneficial effects on skeletal muscle and the cardiovascular system without adverse effects. Recent experiments have also demonstrated that EC has an antitumor effect in a murine breast cancer model.
Article
Cell & Tissue Engineering
Chijimatsu Ryota, Miwa Satoshi, Okamura Gensuke, Miyahara Junya, Tachibana Naohiro, Ishikura Hisatoshi, Higuchi Junya, Maenohara Yuji, Tsuji Shinsaku, Sameshima Shin, Takagi Kentaro, Nakazato Keiu, Kawaguchi Kohei, Yamagami Ryota, Inui Hiroshi, Taketomi Shuji, Sakae Tanaka, Taku Saito
Summary: This study investigated the chondrogenic potential of stem cells derived from adipose tissue and synovium, showing intrinsic differences in chondrogenic factors among cell types and species. The response to TGF beta 1 may play a crucial role in determining the fate of stem cells transplanted into cartilage defects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Komal Ramani, Aaron E. Robinson, Joshua Berlind, Wei Fan, Aushinie Abeynayake, Aleksandra Binek, Lucia Barbier-Torres, Mazen Noureddin, Nicholas N. Nissen, Zehra Yildirim, Ebru Erbay, Jose M. Mato, Jennifer E. Van Eyk, Shelly C. Lu
Summary: Our study identified a SAMe-sensitive mechanism of LARP1 phosphorylation that may be involved in the progression from NASH to HCC.
Article
Immunology
Samira Mansouri, Himanshu Gogoi, Mauricio Pipkin, Tiago N. Machuca, Amir M. Emtiazjoo, Ashish K. Sharma, Lei Jin
Summary: This study found that exogenous IFN beta can reprogram specific lung cells involved in asthma, alleviating symptoms and potentially being used for future treatments.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Ruoyu Wang, Dong Zhang, Dan Tang, Kewei Sun, Jianping Peng, Wenfang Zhu, Sihan Yin, Yunan Wu
Summary: Amygdalin effectively suppressed the activation of hepatic stellate cells induced by TGF-beta 1 by modulating proliferation, fibrogenesis, and inflammation signaling pathways in vitro, leading to improvement in liver fibrosis and damage in a CCl4-stimulated rat model in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meihan Li, Lingzhi Zhang, Jing Li, Qing Zhu
Summary: In this study, osteoblasts from subchondral bone were successfully reprogrammed into chondrocytes, and different combinations of transcription factors were found to guide the reprogramming towards different subpopulations of chondrocytes. These findings have important implications for developing new strategies to treat full-thickness cartilage defects.
Article
Biophysics
Jie Wang, Xiaopeng Liu, Wanyi Xue, Yunyun Wei, Zhangrun Xu
Summary: This study designed a nanoprobe based on a cascade-amplification-reaction for the detection of intracellular telomerase. The method demonstrated fast response and strong fluorescence signals, allowing convenient monitoring of telomerase activity and changes in different types of tumor cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Wenting Dai, Zhichao Wang, Qiong A. Wang, David Chan, Lei Jiang
Summary: This study explored the role of OPA1 in cell fitness and metabolic regulation. When cellular mitochondrial fission is unbalanced, OPA1 deficiency activates glutamine-dependent reductive carboxylation to reprogram cellular metabolism in order to support lipid synthesis and cell proliferation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Chun-peng Liao, Leng-ying Chen, Andrea Luethy, Youngsoo Kim, Kian Kani, A. Robert MacLeod, Mitchell E. Gross
ENDOCRINE-RELATED CANCER
(2017)
Article
Biochemistry & Molecular Biology
Chun-Peng Liao, Tzu-Ping Lin, Pei-Chuan Li, Lauren A. Geary, Kevin Chen, Vijaya Pooja Vaikari, Jason Boyang Wu, Chi-Hung Lin, Mitchell E. Gross, Jean C. Shih
Article
Cell & Tissue Engineering
Lijuan Yin, Jingjing Li, Chun-Peng Liao, Boyang Jason Wu
Article
Oncology
Chun-Peng Liao, Helty Adisetiyo, Mengmeng Liang, Pradip Roy-Burman
Article
Cell Biology
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Joseph H. Jeong, Michael B. Cohen, Pradip Roy-Burman, Baruch Frenkel
JOURNAL OF CELLULAR PHYSIOLOGY
(2014)
Article
Medicine, Research & Experimental
Jason Boyang Wu, Chen Shao, Xiangyan Li, Qinlong Li, Peizhen Hu, Changhong Shi, Yang Li, Yi-Ting Chen, Fei Yin, Chun-Peng Liao, Bangyan L. Stiles, Haiyen E. Zhau, Jean C. Shih, Leland W. K. Chung
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Urology & Nephrology
Kazunori Haga, Atsushi Tomioka, Chun-Peng Liao, Takahiro Kimura, Hiroshi Matsumoto, Izumi Ohno, Kip Hermann, Christopher R. Logg, Jing Jiao, Motoyoshi Tanaka, Yoshihiko Hirao, Hong Wu, Carol A. Kruse, Pradip Roy-Burman, Noriyuki Kasahara
JOURNAL OF UROLOGY
(2009)
Article
Oncology
Lauren A. Geary, Kevin A. Nash, Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Joseph H. Jeong, Ebrahim Zandi, Pradip Roy-Burman
MOLECULAR CANCER RESEARCH
(2014)
Article
Multidisciplinary Sciences
Joseph H. Jeong, Ayesha Bhatia, Zsolt Toth, Soohwan Oh, Kyung-Soo Inn, Chun-Peng Liao, Pradip Roy-Burman, Jonathan Melamed, Gerhard A. Coetzee, Jae U. Jung
Article
Multidisciplinary Sciences
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B. Cohen, Shili Xu, Nouri Neamati, Edward M. Conway, Chieh-Yang Cheng, Alexander Yu. Nikitin, Pradip Roy-Burman
Article
Multidisciplinary Sciences
Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun-Peng Liao, Pradip Roy-Burman, Ebrahim Zandi, Susan Groshen, Jacek Pinski, Gerhard A. Coetzee, Mitchell E. Gross, M. Elizabeth Fini
Article
Endocrinology & Metabolism
Shikha Gaur, Mitchell E. Gross, Chun-Peng Liao, Bin Qian, Jean C. Shih
Article
Biochemistry & Molecular Biology
Jingjing Li, Tianjie Pu, Lijuan Yin, Qinlong Li, Chun-Peng Liao, Boyang Jason Wu
Article
Chemistry, Multidisciplinary
Noah Trac, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Christopher Poon, Jonathan Wang, Yuta Ando, Johan Joo, Carolina Garri, Keyue Shen, Kian Kani, Mitchell E. Gross, Eun Ji Chung
Summary: Signaling via MCP-1/CCR2 axis plays a crucial role in promoting cancer progression, while KLAK-MCP-1 micelles inhibit tumor growth by targeting CCR2 and altering the composition of cells in the tumor microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2021)