Article
Oncology
Kaori Watanabe, Kazuyoshi Shiga, Anri Maeda, Shinnosuke Harata, Takeshi Yanagita, Takuya Suzuki, Hajime Ushigome, Yuzo Maeda, Takahisa Hirokawa, Ryo Ogawa, Masayasu Hara, Hiroki Takahashi, Yoichi Matsuo, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
Summary: The present study investigated the secretion of CHI3L1 in the microenvironment of colorectal cancer and its effect on tumor angiogenesis. It was found that CHI3L1 secreted by CAFs can increase the secretion of IL-8, thereby affecting tumor angiogenesis in colorectal cancer.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siyu Li, Hongmei Huang, Yan Zhang, Ling Li, Ziyu Hua
Summary: This study investigated the neuroinflammation type of A1-like astrocytes induced by unconjugated bilirubin (UCB) and its underlying regulatory mechanisms. The results showed that UCB stimulation activated A1-like astrocytes, and the inhibition of NF-Kappa B and caspase-1 alleviated A1-like astrocytes and exerted anti-inflammatory protective effects.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meng Mao, Qian Xia, Gao-Feng Zhan, Qin-Jun Chu, Xing Li, Hong-Kai Lian
Summary: This study explored the function and mechanism of SENP6 in microglia-induced neuroinflammation after ischemic stroke. The results showed that SENP6 promoted detrimental microglial phenotype polarization by regulating the de-SUMOylation of ANXA1, activating the NF-κB pathway, and enhancing proinflammatory cytokine expression. In addition, inhibition of SENP6 in microglia effectively reduced neuronal damage induced by ischemic stroke. Furthermore, targeted knockdown of SENP6 in microglia/macrophages significantly improved brain ischemic infarct, neurological deficits, and motor and cognitive function in mice.
CELL AND BIOSCIENCE
(2022)
Article
Immunology
Esther Strating, Mathijs P. P. Verhagen, Emerens Wensink, Ester Duennebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez de la Cruz, Niek A. A. Peters, Joris H. H. Hageman, Mirjam M. C. van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G. G. Elias, Onno Kranenburg
Summary: A co-culture model system of colon cancer organoids and cancer-associated fibroblasts (CAFs) was established, which can recapitulate the histological, biophysical, and immunosuppressive features of aggressive mesenchymal-like human colorectal cancer (CRC). This model can be used to study the mechanisms of immunosuppression and test therapeutic strategies targeting the interaction between CAFs and cancer cells. Furthermore, it can be modified to represent different colon cancer subtypes and (organ-specific) microenvironments.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Fei Su, Alexes C. Daquinag, Songyeon Ahn, Achinto Saha, Yulin Dai, Zhongming Zhao, John DiGiovanni, Mikhail G. Kolonin
Summary: Tumor aggressiveness is linked with obesity and recruitment of adipose stromal cells, which promote cancer through CXCL12 expression. Clinical sample analysis shows increased CXCL12 expression in peritumoral adipose stroma, correlating with decreased survival in patients with prostate carcinoma.
NPJ PRECISION ONCOLOGY
(2021)
Article
Pathology
Shyh-Han Tan, Denise Young, Yongmei Chen, Huai-Ching Kuo, Alagarsamy Srinivasan, Albert Dobi, Gyorgy Petrovics, Jennifer Cullen, David G. Mcleod, Inger L. Rosner, Shiv Srivastava, Isabell A. Sesterhenn
Summary: The study revealed a significant association between ANXA2 expression and progression of prostate cancer, suggesting a potential use of ANXA2 as a prognostic biomarker for aggressive prostate cancer.
Article
Oncology
Nicolo Bancaro, Bianca Cali, Martina Troiani, Angela Rita Elia, Rydell Alvarez Arzola, Giuseppe Attanasio, Ping Lai, Mateus Crespo, Bora Gurel, Rita Pereira, Christina Guo, Simone Mosole, Daniela Brina, Mariantonietta D'Ambrosio, Emiliano Pasquini, Clarissa Spataro, Elena Zagato, Andrea Rinaldi, Mattia Pedotti, Simona Di Lascio, Francesco Meani, Monica Montopoli, Matteo Ferrari, Andrea Gallina, Luca Varani, Ricardo Pereira Mestre, Marco Bolis, Silke Gillessen Sommer, Johann de Bono, Arianna Calcinotto, Andrea Alimonti
Summary: Tumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. We have identified a subset of neutrophils that have upregulated expression of cellular senescence markers and persist in the tumor microenvironment. These senescent-like neutrophils express TREM2 and are more immunosuppressive and tumor-promoting than canonical immunosuppressive neutrophils.
Article
Cell Biology
Alberto Losada-Garcia, Ivan Salido-Guadarrama, Sergio Alberto Cortes-Ramirez, Marian Cruz-Burgos, Miguel Morales-Pacheco, Karla Vazquez-Santillan, Griselda Rodriguez-Martinez, Imelda Gonzalez-Ramirez, Vanessa Gonzalez-Covarrubias, Carlos Perez-Plascencia, Mauricio Rodriguez-Dorantes
Summary: Prostate cancer is the second most common cancer worldwide with a high mortality rate. This study investigates the role of SFRP1 in prostate cancer stem cell phenotype and reveals its involvement in disease progression and therapeutic failure through deregulation of the WNT/beta-catenin pathway. These findings enhance our molecular understanding of castration-resistant prostate cancer and may provide new insights for diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Elif Akova Oelken, Attila Aszodi, Hanna Taipaleenmaeki, Hiroaki Saito, Veronika Schoenitzer, Michael Chaloupka, Maria Apfelbeck, Wolfgang Boecker, Maximilian Michael Saller
Summary: Prostate cancer bone metastasis is one of the most fatal cancer diagnoses for men, and overexpression of the SFRP2 gene may increase the chance of survival of prostate cancer cells within bone tissue by modulating cell characteristics and attachment, which is a key mechanism of metastasis.
Article
Biochemistry & Molecular Biology
Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narita
Summary: The study found that aging in the hypothalamus contributes to increased anxiety, impaired motor coordination, and reduced muscle strength in mice. Aging leads to the production of PD-1-enriched exhausted microglia and neuroinflammatory A1-like reactive astrocytes in the hypothalamus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Mengying Yao, Bing Cui, Weihong Zhang, Wentao Ma, Gaofeng Zhao, Lihua Xing
Summary: This study characterized the effects of miR-21 delivered by exosomes from MSCs on macrophage polarization in a mouse sepsis model. Beta MSC-derived exosomes induced M2-like polarization of macrophages more effectively, improving survival rates in septic mice. Exosomal miR-21 was identified as a key mediator of the immunomodulatory properties of MSCs induced by IL-1 beta pretreatment, providing a potential therapeutic basis for sepsis.
Article
Food Science & Technology
Eloise Keeling, Savannah A. Lynn, Yen Min Koh, Jenny A. Scott, Aaron Kendall, Maureen Gatherer, Anton Page, Felino R. Cagampang, Andrew J. Lotery, J. Arjuna Ratnayaka
Summary: This study demonstrates that prolonged exposure to an unhealthy Western-style diet alone can lead to the development of early-intermediate AMD-like features in wildtype mice, highlighting the importance of diet and nutrition in the etiology of sight-loss.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
Feng Zhang, Feiyan Li, Jinghe Lu
Summary: This study investigated the mechanisms of hUC-MSC-EVs loaded with miR-100 in regulating the growth dynamics of endometrial stromal cells in endometriosis. It was found that miR-100 could be transferred into the endometrial stromal cells via hUC-MSC-EVs and promote cell proliferation, invasion, migration, and epithelial-mesenchymal transition by inhibiting HS3ST2. These findings provide a promising therapeutic target for treating endometriosis.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Lei Chen, Yue-Yang Wang, Deng Li, Cheng Wang, Shi-Yuan Wang, Si-Hui Shao, Zheng-Yang Zhu, Jing Zhao, Yu Zhang, Yuan Ruan, Bang-Min Han, Shu-Jie Xia, Chen-Yi Jiang, Fu-Jun Zhao
Summary: The study identified LMO2 as a target gene of AR in prostate fibroblasts and found that its overexpression due to AR deactivation promotes the growth of PCa cells through IL-11 and FGF-9 release in a non-cell-autonomous manner.
Article
Pharmacology & Pharmacy
Masyitah Hasan, Endang Kumolosasi, Ibrahim Jantan, Malina Jasamai, Norlaili Nazarudin
Summary: Annexin A1 (ANXA1), an endogenous protein, plays important roles in the regulation of proliferation, cell cycle, phagocytosis, and apoptosis in leukemia cells. Knockdown of ANXA1 led to decreased expression and induced apoptosis in leukemia cells. It also affected the expression of caspases and Bcl-2, and enhanced phagocytosis activity. These findings suggest that ANXA1 knockdown might be a potential therapeutic strategy for leukemia.
ACTA PHARMACEUTICA
(2022)
Article
Oncology
Chun-peng Liao, Leng-ying Chen, Andrea Luethy, Youngsoo Kim, Kian Kani, A. Robert MacLeod, Mitchell E. Gross
ENDOCRINE-RELATED CANCER
(2017)
Article
Biochemistry & Molecular Biology
Chun-Peng Liao, Tzu-Ping Lin, Pei-Chuan Li, Lauren A. Geary, Kevin Chen, Vijaya Pooja Vaikari, Jason Boyang Wu, Chi-Hung Lin, Mitchell E. Gross, Jean C. Shih
Article
Cell & Tissue Engineering
Lijuan Yin, Jingjing Li, Chun-Peng Liao, Boyang Jason Wu
Article
Oncology
Chun-Peng Liao, Helty Adisetiyo, Mengmeng Liang, Pradip Roy-Burman
Article
Cell Biology
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Joseph H. Jeong, Michael B. Cohen, Pradip Roy-Burman, Baruch Frenkel
JOURNAL OF CELLULAR PHYSIOLOGY
(2014)
Article
Medicine, Research & Experimental
Jason Boyang Wu, Chen Shao, Xiangyan Li, Qinlong Li, Peizhen Hu, Changhong Shi, Yang Li, Yi-Ting Chen, Fei Yin, Chun-Peng Liao, Bangyan L. Stiles, Haiyen E. Zhau, Jean C. Shih, Leland W. K. Chung
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Urology & Nephrology
Kazunori Haga, Atsushi Tomioka, Chun-Peng Liao, Takahiro Kimura, Hiroshi Matsumoto, Izumi Ohno, Kip Hermann, Christopher R. Logg, Jing Jiao, Motoyoshi Tanaka, Yoshihiko Hirao, Hong Wu, Carol A. Kruse, Pradip Roy-Burman, Noriyuki Kasahara
JOURNAL OF UROLOGY
(2009)
Article
Oncology
Tong Xu, Yucheng Xu, Chun-Peng Liao, Roy Lau, Amir Goldkorn
MOLECULAR CANCER THERAPEUTICS
(2010)
Article
Multidisciplinary Sciences
Joseph H. Jeong, Ayesha Bhatia, Zsolt Toth, Soohwan Oh, Kyung-Soo Inn, Chun-Peng Liao, Pradip Roy-Burman, Jonathan Melamed, Gerhard A. Coetzee, Jae U. Jung
Article
Multidisciplinary Sciences
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B. Cohen, Shili Xu, Nouri Neamati, Edward M. Conway, Chieh-Yang Cheng, Alexander Yu. Nikitin, Pradip Roy-Burman
Article
Multidisciplinary Sciences
Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun-Peng Liao, Pradip Roy-Burman, Ebrahim Zandi, Susan Groshen, Jacek Pinski, Gerhard A. Coetzee, Mitchell E. Gross, M. Elizabeth Fini
Article
Endocrinology & Metabolism
Shikha Gaur, Mitchell E. Gross, Chun-Peng Liao, Bin Qian, Jean C. Shih
Article
Biochemistry & Molecular Biology
Jingjing Li, Tianjie Pu, Lijuan Yin, Qinlong Li, Chun-Peng Liao, Boyang Jason Wu
Article
Chemistry, Multidisciplinary
Noah Trac, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Christopher Poon, Jonathan Wang, Yuta Ando, Johan Joo, Carolina Garri, Keyue Shen, Kian Kani, Mitchell E. Gross, Eun Ji Chung
Summary: Signaling via MCP-1/CCR2 axis plays a crucial role in promoting cancer progression, while KLAK-MCP-1 micelles inhibit tumor growth by targeting CCR2 and altering the composition of cells in the tumor microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2021)