Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Article
Biochemistry & Molecular Biology
Shohreh Azadi, Ehsan Mohammadi, Mohammad Tafazzoli-Shadpour, Mohammad Tabatabaei
Summary: The development of cancer involves changes in cell structure and physical state. This study shows that there is a synergy between the physical and biological behaviors of cancer cells, with the physical behaviors being affected by targeting proteins involved in biological behaviors. By targeting EGRF, the researchers were able to alter the physical behaviors of breast cancer cells, leading to a decrease in cell invasion and viability. The findings suggest that the synergy between physical and chemical pathways can enhance the efficacy of anti-cancer drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Huaiping Cui, Han Li, Hao Wu, Fengying Du, Xiaozhou Xie, Shujie Zeng, Zihao Zhang, Kangdi Dong, Liang Shang, Changqing Jing, Leping Li
Summary: This study discovered a novel tRNA-derived fragment, tRF-Val, which was significantly upregulated in gastric cancer tissues and cell lines. tRF-Val expression was positively associated with tumor size and invasion depth in gastric cancer tissues. Functionally, tRF-Val promoted proliferation and invasion, while inhibiting apoptosis in gastric cancer cells. Mechanistically, tRF-Val directly bound to the chaperone molecule EEF1A1, facilitated its transport into the nucleus, and promoted its interaction with MDM2, thus inhibiting the downstream molecular pathway of p53 and promoting gastric cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Oncology
Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen, Yan Zheng
Summary: SPP1 plays a critical role in promoting cell migration and invasion in lung adenocarcinoma by upregulating COL11A1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Li-zhe Xu, Jin-zhuo Ning, Yuan Ruan, Fan Cheng
Summary: miR-363-3p promotes prostate cancer growth, migration, and invasion by targeting DKK3, while dampening apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Dian Lv, Qi Lai, Qi Zhang, Ji-Hong Wang, Yuan-Ce Li, Guang-Zhi Zeng, Jun-Lin Yin
Summary: The compound 3-desoxysulforaphane (3-DSC) isolated from Caesalpinia sinensis showed antitumor activity by inhibiting cell proliferation, migration, and invasion in HeLa and PC3 cells through modulation of multiple signaling pathways.
Article
Oncology
Dana Messinger, Micah K. Harris, Jessica R. Cummings, Chase Thomas, Tao Yang, Stefan R. Sweha, Rinette Woo, Robert Siddaway, Martin Burkert, Stefanie Stallard, Tingting Qin, Brendan Mullan, Ruby Siada, Ramya Ravindran, Michael Niculcea, Abigail Dowling, Joshua Bradin, Kevin F. Ginn, Melissa A. H. Gener, Kathleen Dorris, Nicholas A. Vitanza, Susanne Schmidt, Jasper Spitzer, Li Jiang, Mariella G. Filbin, Xuhong Cao, Maria G. Castro, Pedro R. Lowenstein, Rajen Mody, Arul Chinnaiyan, Pierre-Yves Desprez, Sean McAllister, Matthew D. Dun, Cynthia Hawkins, Sebastian M. Waszak, Sriram Venneti, Carl Koschmann, Viveka Nand Yadav
Summary: This study found that upregulation of the protein ID1 is associated with H3K27M and ACVR1 mutations in diffuse midline gliomas (DMG). Experimental evidence shows that ID1 plays a role in tumor growth and invasion, and inhibition of ID1 with cannabidiol (CBD) can decrease invasion and growth of DMG tumors. This discovery may provide new possibilities for the treatment of DMG.
Article
Oncology
Jin-Xing Zhang, Wei Yang, Jun-Zheng Wu, Chun Zhou, Sheng Liu, Hai-Bin Shi, Wei-Zhong Zhou
Summary: The study found that miR-32-5p is downregulated in NSCLC tissues and inhibits the migration and invasion abilities of tumors by targeting SMAD3. miR-32-5p may be a potential therapeutic target for the treatment of lung adenocarcinoma.
Article
Biochemistry & Molecular Biology
Tara Lancaster, Maral E. A. Tabrizi, Mariaelena Repici, Janesh Gupta, Stephane R. Gross
Summary: Although S100P is known to be a marker for carcinogenesis, its expression in non-physio-pathological states promotes trophoblast motility and invasion. The mechanisms behind these cellular processes were unknown until this study, where it was found that S100P is present on the plasma membrane/cell surface of all tested trophoblast cells. Inhibiting cell surface-bound or extracellular S100P pools significantly reduced cellular motility and invasion, uncovering two newly characterized pathways through which S100P promotes trophoblast cellular motility and invasion.
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Plant Sciences
Dragana S. Seklic, Milena M. Jovanovic, Katarina D. Virijevic, Jelena N. Grujic, Marko N. Zivanovic, Snezana D. Markovic
Summary: The study focused on the antimigratory/invasive potential of Pseudevernia furfuracea methanol extract on colorectal carcinoma cell lines and highlighted its ability to suppress cancer cell migration by inhibiting expression of promigratory/invasive markers. Results suggest that P. furfuracea could be an effective antimigratory treatment for cancer, particularly in preventing metastasis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Rui Zhao, Yuzhen Ge, Yongjun Gong, Bo Li, Benli Xiao, Shi Zuo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. This study found that low expression of NAP1L5 in HCC was associated with shorter survival and disease-free survival. NAP1L5 inhibited the proliferation, migration, and invasion of hepatoma cells, and induced apoptosis. It also inhibited the growth and metastasis of HCC cells in vivo. Mechanistically, NAP1L5 regulated the PI3K/AKT/mTOR signaling pathway by controlling MYH9 to affect the occurrence and development of HCC. NAP1L5 may be a potential target for liver cancer treatment.
Article
Biochemistry & Molecular Biology
Jing Wang, Man Li, Meigui Wang, Jing Yang, Deguang Li, Yunxia Hao
Summary: Accumulating evidence suggests that miRNAs play a crucial role in lung adenocarcinoma. The specific contributions and mechanisms of miR-181c-5p in lung adenocarcinoma are not well understood. This study aimed to clarify the potential mechanism by which miR-181c-5p regulates the progression of lung adenocarcinoma. The results showed that miR-181c-5p was up-regulated in lung adenocarcinoma tissues and cells. Inhibition of miR-181c-5p suppressed the viability, migration, and invasion of lung adenocarcinoma cells. It was also found that miR-181c-5p targeted the PRKN gene and mediated its functions in lung adenocarcinoma progression. These findings suggest that miR-181c-5p could be a potential diagnostic and predictive marker for lung adenocarcinoma, offering new insights into the development of treatment strategies.
BIOCHEMICAL GENETICS
(2023)
Article
Medicine, Research & Experimental
Catherine E. Willoughby, Yanyan Jiang, Huw D. Thomas, Elaine Willmore, Suzanne Kyle, Anita Wittner, Nicole Phillips, Yan Zhao, Susan J. Tudhope, Lisa Prendergast, Gesa Junge, Luiza Madia Lourenco, M. Raymond V. Finlay, Paul Turner, Joanne M. Munck, Roger J. Griffin, Tommy Rennison, James Pickles, Celine Cano, David R. Newell, Helen L. Reeves, Anderson J. Ryan, Stephen R. Wedge
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Oncology
Agata Patel, Elena Seraia, Daniel Ebner, Anderson Joseph Ryan
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp H. Richter, Marsha D. Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson J. Ryan, Joanna L. Selfe, Janet Shipley, Siddhartha Kar, Paul D. Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel Ebner, Meghana Pagadala, Sarah P. Blagden, Timothy S. Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth L. Bond
Summary: Insights from cancer susceptibility loci suggest potential for improved cancer management through precision oncology, highlighting the importance of understanding interactions between germline variants and somatic mutations in tumorigenesis. This study proposes that cancer risk-associated germline variants interact with somatic TP53 mutations to modify cancer risk, progression, and therapy response, offering a novel approach for therapeutic targeting of p53 activities and identifying new combinatorial therapies.
Article
Oncology
Guillaume Rieunier, Xiaoning Wu, Letitia E. Harris, Jack Mills, Ashwin Nandakumar, Laura Colling, Elena Seraia, Stephanie B. Hatch, Daniel Ebner, Lisa K. Folkes, Ulrike Weyer-Czernilofsky, Thomas Bogenrieder, Anderson J. Ryan, Valentine M. Macaulay
Summary: Inhibition of IGF1R delays repair of radiation-induced DNA damage and influences endogenous DNA damage by regulating RRM2 expression. IGF axis blockade induces replication stress and reciprocal codependence on ATM, providing a potential therapeutic approach for ATM-deficient cancers.
Article
Oncology
Yanyan Jiang, Jennifer Martin, Maryam Alkadhimi, Kay Shigemori, Paul Kinchesh, Stuart Gilchrist, Veerle Kersemans, Sean Smart, James M. Thompson, Mark A. Hill, Mark J. O'Connor, Barry R. Davies, Anderson J. Ryan
Summary: The study found that the addition of olaparib increased the therapeutic index of hemithoracic radiation in a mouse model of lung cancer, enhancing anti-tumour efficacy without increasing lung toxicity.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biotechnology & Applied Microbiology
Peter Kok-Ting Wan, Anderson J. Ryan, Leonard W. Seymour
Summary: Cancer gene therapies targeting the tumor microenvironment have shown promising results by focusing on strategies that target the cancer stroma, reduce tumor vasculature, and repolarize the immunosuppressive microenvironment. This approach is appealing because the genetically stable TME plays a crucial role in promoting cancer growth, immune tolerance, and resistance to therapies, especially in the presence of multiple mutations in cancers.
Article
Oncology
T. Cascone, R. L. Sacks, I. M. Subbiah, N. Drobnitzky, S. A. Piha-Paul, D. S. Hong, K. R. Hess, B. Amini, T. Bhatt, S. Fu, A. Naing, F. Janku, D. Karp, G. S. Falchook, A. P. Conley, S. Sherman, F. Meric-Bernstam, A. J. Ryan, J. Heymach, V Subbiah
Summary: The combination therapy of VAN + EV shows promising antitumor activity in advanced solid cancers, with manageable toxicities. Further studies are needed to explore its efficacy in tumors with RET pathway aberrations.
Article
Oncology
Yanyan Jiang, Elaine Willmore, Stephen R. Wedge, Anderson J. Ryan
Summary: The inhibition of DNAPK has been shown to enhance the sensitivity of chronically hypoxic tumor cells to radiation, with a more pronounced inhibitory effect on DNA DSB repair, suggesting a broader therapeutic window for transient DNAPK inhibition combined with radiotherapy.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Florian J. Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A. Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Summary: The compound pyridostatin shows high specificity against BRCA1/2-deficient tumors and tumors resistant to PARP inhibitors. It disrupts replication leading to DNA double-stranded breaks and can be repaired in the absence of BRCA1/2 by non-homologous end joining. Additionally, pyridostatin triggers immune responses and can be further potentiated by combining it with paclitaxel. Overall, pyridostatin has potential for therapeutic development in cancer patients with BRCA1/2 mutations.
EMBO MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoning Wu, Elena Seraia, Stephanie B. Hatch, Xiao Wan, Daniel V. Ebner, Francesca Aroldi, Yanyan Jiang, Anderson J. Ryan, Thomas Bogenrieder, Ulrike Weyer-Czernilofsky, Guillaume Rieunier, Valentine M. Macaulay
Summary: Inhibition of both IGF and CHK1 leads to synergistic suppression of cell viability and tumor growth by downregulating RRM2 expression and reducing dNTP supply, resulting in delayed DNA replication and accumulation of unreplicated single-stranded DNA. This study highlights the therapeutic potential of targeting the IGF:CHK1 interaction and identifies RRM2 as a key target for synthetic lethality in cancer therapy.
Article
Biochemical Research Methods
Stephen M. Stribbling, Anderson J. Ryan
Summary: Tumor-bearing experimental animals are crucial for preclinical cancer drug development, with the subcutaneous tumor model being the most commonly used. This article provides an overview of different in vivo tumor models, including their advantages and disadvantages and their role in drug development. It then details the establishment and key steps of the subcutaneous tumor model.
Article
Engineering, Biomedical
Frank van den Heuvel, Anna Vella, Francesca Fiorini, Mark Brooke, Mark Hill, Anderson Ryan, Tim Maughan, Amato Giaccia
Summary: A methodology for predicting tissue sparing effects in pulsed ultra-high dose rate radiation exposures is introduced and illustrated using published experiments. The proposed system quantifies the effects by formalizing the variability of oxygen levels as an oxygen dose histogram and calculating the change in DNA-damage induction based on the oxygen fixation concept. The results show that the FLASH-effect depends on the initial oxygenation level in tissue, the total dose delivered, pulse length, and pulse repetition rate.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katharine J. Herbert, Rathi Puliyadi, Remko Prevo, Gonzalo Rodriguez-Berriguete, Anderson Ryan, Kristijan Ramadan, Geoff S. Higgins
Summary: The study confirms the potential of TOPK as a target for treating solid tumors, shows that TOPK inhibitor in combination with radiation treatment can enhance efficacy, and reveals a previously unknown role of TOPK during S phase supporting cancer cell survival.
CELL DEATH AND DIFFERENTIATION
(2021)
Meeting Abstract
Oncology
Yanyan Jiang, Anderson Ryan
Article
Oncology
Gerard M. Walls, Jamie B. Oughton, Anthony J. Chalmers, Sarah Brown, Fiona Collinson, Martin D. Forster, Kevin N. Franks, Alexandra Gilbert, Gerard G. Hanna, Nicola Hannaway, Stephen Harrow, Tom Haswell, Crispin T. Hiley, Samantha Hinsley, Matthew Krebs, Geraldine Murden, Rachel Phillip, Anderson J. Ryan, Ahmed Salem, David Sebag-Montefoire, Paul Shaw, Chris J. Twelves, Katrina Walker, Robin J. Young, Corinne Faivre-Finn, Alastair Greystoke
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2020)