How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

Conformational Effects on the pro - S Hydrogen Abstraction Reaction in Cyclooxygenase-1: An Integrated QM/MM and MD Study

(2013) Christo Z. Christov et al.   BIOPHYSICAL JOURNAL

A molecular dynamics investigation on the crizotinib resistance mechanism of C1156Y mutation in ALK

(2012) Hui-Yong Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

(2012) Linda F. Epstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Taking Ockham's razor to enzyme dynamics and catalysis

(2012) David R. Glowacki et al.   Nature Chemistry

Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

ALK signaling and target therapy in anaplastic large cell lymphoma

(2012) Fabrizio Tabbó   Frontiers in Oncology

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

(2010) Christian C. Lee et al.   BIOCHEMICAL JOURNAL

Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors

(2010) Roberto T. Bossi et al.   BIOCHEMISTRY

Structural Fluctuations in Enzyme-Catalyzed Reactions: Determinants of Reactivity in Fatty Acid Amide Hydrolase from Multivariate Statistical Analysis of Quantum Mechanics/Molecular Mechanics Paths

(2010) Alessio Lodola et al.   Journal of Chemical Theory and Computation

Conformational averaging in structural biology: issues, challenges and computational solutions

(2009) Daniela Kruschel et al.   Molecular BioSystems

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE