期刊
MOLECULAR BIOSYSTEMS
卷 10, 期 6, 页码 1490-1495出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mb00141a
关键词
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资金
- Bulgarian-American Fulbright Commission
- Engineering and Physical Sciences Research Council [EP/J003921/1] Funding Source: researchfish
- EPSRC [EP/J003921/1] Funding Source: UKRI
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme.
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