Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research

Research on DNA methylation of human osteosarcoma cell MGMT and its relationship with cell resistance to alkylating agents

(2013) Jun Guo et al.   Biochemistry and Cell Biology

Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

(2013) A. Amatu et al.   CLINICAL CANCER RESEARCH

Effect of lomeguatrib–temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells

(2013) Mehmet Taspinar et al.   TUMOR BIOLOGY

Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients

(2012) S. Challouf et al.   CLINICA CHIMICA ACTA

Strategies to Improve the Killing of Tumors Using Temozolomide: Targeting the DNA Repair Protein MGMT

(2012) G. Jiang et al.   CURRENT MEDICINAL CHEMISTRY

RNAi-mediated gene silencing in cancer therapy

(2012) Wei-Qiong Yang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts

(2011) Deborah S. Malley et al.   ACTA NEUROPATHOLOGICA

A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy

(2011) Guan Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O6-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma

(2011) Reiko Watanabe et al.   Brain Tumor Pathology

The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas-correlation with array comparative genome hybridization results and IDH1 mutation

(2011) Katja Tuononen et al.   GENES CHROMOSOMES & CANCER

Combining conditionally replicating adenovirus-mediated gene therapy with chemotherapy: A novel antitumor approach

(2011) Guan Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

(2011) S. Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Temozolomide: Mechanisms of Action, Repair and Resistance

(2011) Jihong Zhang et al.   Current Molecular Pharmacology

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide

(2010) K A van Nifterik et al.   BRITISH JOURNAL OF CANCER

Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter

(2010) Kazuya Motomura et al.   CANCER

Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene

(2010) Jun-Nian Zheng et al.   CANCER BIOLOGY & THERAPY

Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazine against melanoma cells via induction of apoptosis

(2010) Guan Jiang et al.   CANCER LETTERS

Targeting O 6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

(2010) Bernd Kaina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas

(2010) Francesca R. Buttarelli et al.   CHILDS NERVOUS SYSTEM

Tumor O6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib

(2010) A. J. Watson et al.   CLINICAL CANCER RESEARCH

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

(2010) T Kato et al.   GENE THERAPY

Minimally Cytotoxic Doses of Temozolomide Produce Radiosensitization in Human Glioblastoma Cells Regardless of MGMT Expression

(2010) M. S. Bobola et al.   MOLECULAR CANCER THERAPEUTICS

Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide

(2010) George C. Bobustuc et al.   NEURO-ONCOLOGY

Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma

(2010) Sung-Hsien Huang et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib

(2009) A J Watson et al.   BRITISH JOURNAL OF CANCER

CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma

(2009) L N Kaliberova et al.   CANCER GENE THERAPY

Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma

(2009) C. K. Augustine et al.   CLINICAL CANCER RESEARCH

Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas

(2009) Deok-Joo Rhee et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors

(2009) Lu-Ting Kuo et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA

(2008) J-N Zheng et al.   CANCER GENE THERAPY

Silencing of MGMT expression by promoter hypermethylation in the metaplasia–dysplasia–carcinoma sequence of Barrett’s esophagus

(2008) Doerthe Kuester et al.   CANCER LETTERS

IFN-  sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression

(2008) S. F. Rosati et al.   MOLECULAR CANCER THERAPEUTICS