Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Raul Garcia-Gonzalez, Eva Monte-Serrano, Patricia Morejon-Garcia, Elena Navarro-Carrasco, Pedro A. Lazo
Summary: This study reveals the role of VRK1 chromatin kinase in the activation of Tip60 and the cooperation between VRK1 and DNA-PK in Tip60 phosphorylation. T158 phosphorylation protects Tip60 from degradation, promotes its recruitment to chromatin, and is necessary for its full activity. S199 phosphorylation directly facilitates Tip60 autoacetylation. These findings are important for understanding the regulatory mechanisms of chromatin remodeling in the DNA damage response.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Milad Shirvaliloo
Summary: The article summarizes the importance of histones and their role in gene expression regulation. It highlights the significance of recent research on histone modifications published in Epigenomics since 2020.
Review
Pharmacology & Pharmacy
Soorya P. Illam, Sruthi P. Kandiyil, Achuthan C. Raghavamenon
Summary: Epigenetic mechanisms, such as DNA methylation and histone modifications, regulate gene expression and play important roles in normal growth and metabolism. Aberrant histone modifications are linked to pathological conditions and have been a focus of research. Nutri-epigenetics explores the influence of dietary compounds on epigenetics.
CURRENT DRUG TARGETS
(2021)
Article
Cell Biology
Fang Zhang, Mert Icyuz, Andrzej Bartke, Liou Y. Sun
Summary: The study showed that GH intervention during early life significantly altered histone H3 markers in Ames dwarf mice, resulting in tissue-specific changes in H3 lysine methylation and acetylation. These findings indicate an important epigenetic mechanism by which hormonal signals during early life can influence aging and longevity in mammals.
Review
Biochemistry & Molecular Biology
Hirotomo Takatsuka, Atsushi Shibata, Masaaki Umeda
Summary: Plant DNA is vulnerable to environmental stressors, and chromatin plays a crucial role in protecting DNA by altering its structure. Changes in chromatin modifications, regulation of gene expression, and the physical barrier function of condensed chromatin are key mechanisms for plants to maintain genome integrity under genotoxic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rong Huang, Liyan Sui, Cong Fu, Yanhui Zhai, Xiangpeng Dai, Sheng Zhang, Ziyi Li
Summary: Inhibition of HDAC11 significantly affects meiosis by altering acetylation levels of key molecules, leading to disrupted maturation of porcine oocytes and compromised subsequent embryo development.