Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

Development of a Preclinical Orthotopic Xenograft Model of Ewing Sarcoma and Other Human Malignant Bone Disease Using Advanced In Vivo Imaging

(2014) Britta Vormoor et al.   PLoS One

A Novel Role for Keratin 17 in Coordinating Oncogenic Transformation and Cellular Adhesion in Ewing Sarcoma

(2013) Savita Sankar et al.   MOLECULAR AND CELLULAR BIOLOGY

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

(2013) Srikanth R. Ambati et al.   Molecular Oncology

DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma

(2012) K. Hauer et al.   CANCER RESEARCH

Mena binds α5 integrin directly and modulates α5β1 function

(2012) Stephanie L. Gupton et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators

(2012) Laura M. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

(2012) S Sankar et al.   ONCOGENE

The Clone Wars – Revenge of the Metastatic Rogue State: The Sarcoma Paradigm

(2012) Holly L. Spraker et al.   Frontiers in Oncology

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma

(2011) Scott C. Borinstein et al.   CANCER

Mechanisms of cancer cell metastasis to the bone: a multistep process

(2011) Lalit R Patel et al.   Future Oncology

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

Overcoming anoikis - pathways to anchorage-independent growth in cancer

(2011) M. C. Guadamillas et al.   JOURNAL OF CELL SCIENCE

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Promiscuous partnerships in Ewing's sarcoma

(2011) Savita Sankar et al.   Cancer Genetics

Filopodia and adhesion in cancer cell motility

(2011) Antti Arjonen et al.   Cell Adhesion & Migration

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Ewing's sarcoma

(2010) A. O. Karosas   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro

(2010) D. N. T. Aryee et al.   CANCER RESEARCH

A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair

(2010) Mark A. Smith et al.   DEVELOPMENTAL CELL

Evaluation of cytarabine against Ewing sarcoma xenografts by the pediatric preclinical testing program

(2010) Peter J. Houghton et al.   PEDIATRIC BLOOD & CANCER

Integrin switching modulates adhesion dynamics and cell migration

(2010) Hoa Truong et al.   Cell Adhesion & Migration

Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

(2009) D Herrero-Martín et al.   BRITISH JOURNAL OF CANCER

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

(2008) H. Guan et al.   MOLECULAR CANCER THERAPEUTICS

EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma

(2008) Leah A. Owen et al.   PLoS One