Article
Oncology
Miki Nishitani, Scott Moerdler, Jennifer Kesselheim
Summary: The landscape of the pediatric hematology and oncology workforce has been changing, leading to concerns about decreasing interest in the subspecialty. A survey was conducted to evaluate the impact of the initial job search on stress, anxiety, and perceptions of the job search experience among fellows. The results emphasized the need for interventions to enhance the job search experience and highlighted unmet mentorship and educational needs.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pediatrics
Katia Librandi, Serena Grimaldi, Silvia Catalano, Francesco Moro, Stefano Gabriele Vallero, Marco Spada, Francesco Porta
Summary: Tuberous sclerosis complex (TSC) is a rare multisystemic disorder that can include epilepsy as a common feature. This case report highlights the association between TSC and insulinomas, with the first pediatric case of a TSC patient diagnosed with an insulinoma. It emphasizes the importance of considering hypoglycemic events in TSC patients, especially in those with recurrent seizures previously controlled with antiepileptic therapy.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Tao Fu, Jun-Xia Liu, Juan Xie, Zhen Gao, Zhenshan Yang
Summary: This meta-analysis suggests that higher expression of LAMC2 is associated with worse prognosis, lymph node metastasis, TNM stages, and tumor status in various cancers.
Review
Pharmacology & Pharmacy
Kristopher Amaro-Hosey, Immaculada Danes, Antonia Agusti
Summary: A systematic review revealed a high incidence of ADR in pediatric oncohematology patients, along with significant variability in study design and results. Enhancing methodological standards and preventability assessment is crucial for result comparison and identifying areas for improvement in future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Xuemei Xiang, Yunming Li, Xiaoguang Yang, Wang Guo, Pengfei Zhou
Summary: This study aims to evaluate the predictive value of tumour mutation burden (TMB) in the efficacy of immune checkpoint inhibitors (ICIs). The study will compare the efficacy of ICIs between patients with high TMB and low TMB, and assess their impact on overall survival, progression-free survival, and objective response rate. Subgroup analysis, sensitivity analysis, heterogeneity analysis, and publication bias will also be conducted.
Article
Infectious Diseases
Yang Fu, Xiaohua Zhu, Ping Cao, Chen Shen, Xiaowen Qian, Hui Miao, Yi Yu, Hongsheng Wang, Xiaowen Zhai
Summary: mNGS contributes to the clinical management of children with infection during myelosuppression, especially among patients with negative traditional microbial detection. Early implementation of mNGS in children with symptoms has a tendency to reduce the time of infection, fever, and the cost of treatment.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Doralina L. Anghelescu, Stephanie Ryan, Diana Wu, Kyle J. Morgan, Tushar Patni, Yimei Li
Summary: This retrospective study evaluates the opioid-sparing effectiveness of ketamine in pediatric and young adult oncology and hematology patients. The study found that ketamine was associated with significantly reduced opioid consumption in oncology patients, but not in end-of-life patients or the overall study population. The study also found that the opioid-sparing effects of ketamine may vary depending on clinical diagnoses and circumstances of use.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Jose Antonio Villegas Rubio, Pilar Palomo Moraleda, Ana De Lucio Delgado, Gonzalo Solis Sanchez, Belen Prieto Garcia, Corsino Rey Galan
Summary: The usefulness of CRP, PCT, and IL6 as biomarkers in predicting high-risk episodes in pediatric cancer patients with fever was evaluated. The results showed that IL6-1, PCT-2, and CRP-2vs1 had a strong and independent correlation with high-risk episodes.
Article
Pediatrics
Andrada Mara Ardelean, Ioana Cristina Olariu, Raluca Isac, Ruxandra Jurac, Cristiana Stolojanu, Mircea Murariu, Ana-Olivia Toma, Laurentiu Braescu, Adelina Mavrea, Gabriela Doros
Summary: This study evaluated the correlation between Speckle tracking-echocardiography (STE) and traditional biomarkers in predicting anthracycline-induced cardiotoxicity in pediatric hemato-oncology patients. The results showed that STE can be a sensitive tool for early detection and prediction of cardiotoxicity, but it should be used in conjunction with clinical findings and cardiac biomarkers.
Article
Oncology
Emil Sundberg, Tove Hoffman, Anna Nilsson, Simon Pahnke, Gunilla Enblad, Linda Kolstad, Bengt Ronnberg, Ake Lundkvist, Milla Torkki, Otto Zhou, Jenna Anderson, Arja Harila-Saari, Josefine Palle
Summary: Pediatric oncology and hematology patients in Sweden developed antibodies against SARS-CoV-2 despite their diagnosis and/or treatment, and the observed seroprevalence was similar to that in national pediatric outpatients. PCR-verified cases underestimate the true incidence of COVID-19 in this patient cohort.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Nozomu Kawashima
Summary: This study aimed to evaluate treatment modalities and patients' attitude towards integrative oncology, focusing on Kampo, in children with hematological diseases and solid tumors. Survey results showed that a significant number of patients received pharmaceutical-grade Kampo extracts and reported high effectiveness. Most patients expressed a desire for integrated use of Kampo in pediatric hematology/oncology and wanted more information about it.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Oncology
Alejandro Mauricio Arancibia, Caroline Brunetto De Farias, Algemir Lunardi Brunetto, Rafael Roesler, Lauro Jose Gregianin
Summary: This study aimed to analyze the impact of hospital care volume on the overall survival of children with cancer in Southern Brazil. The findings show that pediatric cancer patients demonstrate better overall survival when treated in high-volume hospitals.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Scott Moerdler, Bradley Gampel, Jennifer M. Levine, Alexander Chou, Pallavi Madhusoodhan, Jennifer A. Oberg, Joanna Pierro, Stephen S. Roberts, Prakash Satwani
Summary: COVID-19 has disrupted medical practice and education, but has also led to advancements in the field. A local group of researchers united to investigate the impact of the pandemic on pediatric hematology oncology and established a virtual symposium. They found that current education, mentoring, and career expectations are not in line with the needs of current trainees.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Alexander A. Boucher, Brenton J. Francisco, Amanda Pfeiffer, Matthew Martin, Janine Martin, Amy Shova, Jaimie D. Nathan, Gregory M. Tiao, Lori Luchtman-Jones
Summary: A study involving 55 pediatric patients aged 0-21 tested aspirin efficacy, finding that urine thromboxane production may reflect postoperative inflammation. Validation of pediatric normal ranges for urine thromboxane is crucial for future research.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Kaitlyn E. Kowalski, Tara A. Higgins
Summary: The retrospective study compared the clearance time of high-dose methotrexate in pediatric hematology/oncology patients between FPIA and ARK assays. The ARK assay showed a positive bias leading to longer clearance times and increased risk of delayed clearance. Adjusting the clearance threshold could help mitigate this risk.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Raushan T. Kurmasheva, Dias Kurmashev, C. Patrick Reynolds, Min Kang, Jianwrong Wu, Peter J. Houghton, Malcolm A. Smith
PEDIATRIC BLOOD & CANCER
(2018)
Article
Biochemical Research Methods
Hwang Eui Cho, Min H. Kang
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2018)
Article
Oncology
Michael M. Song, Monish R. Makena, Ashly Hindle, Balakrishna Koneru, Thinh H Nguyen, Dattesh U. Verlekar, Hwangeui Cho, Barry J. Maurer, Min H. Kang, C. Patrick Reynolds
Article
Oncology
Monish R. Makena, Hwang Eui Cho, Thinh H. Nguyen, Balakrishna Koneru, Dattesh U. Verlekar, Ashly Hindle, Min H. Kang, C. Patrick Reynolds
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Caitlin D. Lowery, Michele Dowless, Matthew Renschler, Wayne Blosser, Alle B. VanWye, Jennifer R. Stephens, Philip W. Iversen, Aimee Bence Lin, Richard P. Beckmann, Kateryna Krytska, Kristina A. Cole, John M. Maris, Douglas S. Hawkins, Brian P. Rubin, Raushan T. Kurmasheva, Peter J. Houghton, Richard Gorlick, E. Anders Kolb, Min H. Kang, C. Patrick Reynolds, Stephen W. Erickson, Beverly A. Teicher, Malcolm A. Smith, Louis F. Stancato
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Ismail S. Mohiuddin, Sung-Jen Wei, Min H. Kang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Biochemical Research Methods
Hwang Eui Cho, Barry J. Maurer, C. Patrick Reynolds, Min H. Kang
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Review
Oncology
Ismail S. Mohiuddin, Min H. Kang
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Thinh H. Nguyen, Balakrishna Koneru, Sung-Jen Wei, Wan Hsi Chen, Monish Ram Makena, Eduardo Urias, Min H. Kang, C. Patrick Reynolds
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Cell Biology
Sung-Jen Wei, Thinh H. Nguyen, In-Hyoung Yang, Dustin G. Mook, Monish Ram Makena, Dattesh Verlekar, Ashly Hindle, Gloria M. Martinez, Shengping Yang, Hiroyuki Shimada, C. Patrick Reynolds, Min H. Kang
CELL DEATH & DISEASE
(2020)
Review
Oncology
Alexander Kroll, Hwang Eui Cho, Min H. Kang
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Jacob S. Thomas, Anthony B. El-Khoueiry, Barry J. Maurer, Susan Groshen, Jacek K. Pinski, Everardo Cobos, David R. Gandara, Heinz J. Lenz, Min H. Kang, C. Patrick Reynolds, Edward M. Newman
Summary: The study aimed to investigate the tolerability, efficacy, and pharmacokinetics of intravenous lipid emulsion fenretinide in patients with advanced solid tumors. The results showed that the formulation had a manageable safety profile and achieved higher plasma steady-state concentrations of the active metabolite compared to previous capsule formulations.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Maggie H. Chasse, Benjamin K. Johnson, Elissa A. Boguslawski, Katie M. Sorensen, Jessica E. Rosien, Min H. Kang, C. Patrick Reynolds, Lyong Heo, Zachary B. Madaj, Ian Beddows, Gabrielle E. Foxa, Susan M. Kitchen-Goosen, Bart O. Williams, Timothy J. Triche, Patrick J. Grohar
Summary: The study found that rhabdoid tumors are more sensitive to mithramycin and EC8042, with their sensitivity superior to traditional DNA damaging agents and linked to the causative mutation of SMARCB1 deletion in the tumor. Mithramycin can block the activity of SMARCB1-deficient SWI/SNF complex, leading to chromatin remodeling and restoration of cellular differentiation.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ismail S. Mohiuddin, Sung-Jen Wei, In-Hyoung Yang, Gloria M. Martinez, Shengping Yang, Eun J. Cho, Kevin N. Dalby, Min H. Kang
Summary: A novel cell-based luminescence assay was developed to identify inhibitors targeting c-MYC transcriptional activation, leading to the discovery of five potential lead compounds with significant ability to kill cancer cells. Two candidate compounds from the DNA-PKcs assay and three from the MK2 assay were identified through a two-step validation method.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Public, Environmental & Occupational Health
Abdurrahman Kharbat, Habib Abla, Mahmud Alkul, Ranger Kile, Justin White, Cynthia Reinoso Webb, Steven M. Presley, Min H. Kang
Summary: This article describes a system using a hydrogen peroxide vaporization method to decontaminate and reuse N95 respirators, providing support for healthcare institutions in West Texas by decontaminating over 12,000 units of PPE.
INFECTION PREVENTION IN PRACTICE
(2021)