Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas

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Global epistasis makes adaptation predictable despite sequence-level stochasticity

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Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution

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FISHER'S GEOMETRIC MODEL OF ADAPTATION MEETS THE FUNCTIONAL SYNTHESIS: DATA ON PAIRWISE EPISTASIS FOR FITNESS YIELDS INSIGHTS INTO THE SHAPE AND SIZE OF PHENOTYPE SPACE

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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

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Development of Recombinant Hemoglobin-Based Oxygen Carriers

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Molecular Controls of the Oxygenation and Redox Reactions of Hemoglobin

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Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds

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Expression and Purification of Recombinant Hemoglobin in Escherichia coli

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Impact of epistasis and pleiotropy on evolutionary adaptation

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Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape

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Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

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Epistasis between Beneficial Mutations and the Phenotype-to-Fitness Map for a ssDNA Virus

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Initial Mutations Direct Alternative Pathways of Protein Evolution

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Fitness Epistasis and Constraints on Adaptation in a Human Immunodeficiency Virus Type 1 Protein Region

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(2010) J. F. Storz et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates

(2010) J. F. Storz et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

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WHEN COLD IS BETTER: CLIMATE-DRIVEN ELEVATION SHIFTS YIELD COMPLEX PATTERNS OF DIVERSIFICATION AND DEMOGRAPHY IN AN ALPINE SPECIALIST (AMERICAN PIKA,OCHOTONA PRINCEPS)

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Isolation and introgression in the Intermountain West: contrasting gene genealogies reveal the complex biogeographic history of the American pika (Ochotona princeps)

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An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

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Stepwise acquisition of pyrimethamine resistance in the malaria parasite

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Adaptive landscapes and protein evolution

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Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin

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Mechanisms of Hemoglobin Adaptation to High Altitude Hypoxia

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