Article
Biochemistry & Molecular Biology
Agnes Karasik, Catherine A. Wilhelm, Carol A. Fierke, Markos Koutmos
Summary: Mitochondrial diseases are often caused by mutations in mitochondrial tRNA sequences. Research shows that mutations in tRNA can weaken the activity of mtRNase P, leading to mitochondrial dysfunction. Furthermore, mutations in pre-tRNAs can disrupt 5' end processing and methylation activity, contributing to the development of mitochondrial diseases.
Article
Biochemistry & Molecular Biology
Kyoung-Su Choi, Seonjoo Park
Summary: The study assembled the complete chloroplast and mitochondrial genomes of Aeginetia indica, revealing that its chloroplast genome shows massive plastid genes with the loss of one IR, while the mitochondrial genome encodes 53 genes and evidence of intracellular and horizontal gene transfers. Potential candidate gene for causing cytoplasmic male sterility (CMS) development in A. indica is Cox2 (orf43).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Mathijs Nieuwenhuis, Jeroen Groeneveld, Duur K. Aanen
Summary: Fungal and plant mitochondria can exchange DNA with retroviral plasmids. This study focuses on the transfer of tRNA genes between fungal linear plasmids and mitochondrial DNA. The researchers found multiple instances of tRNA gene transfer to fungal plasmids and observed the loss of a tRNA gene from the mitochondrial genome after its transfer to a linear mitochondrial plasmid. The authors propose a mutualistic dependency between the host mitochondrial DNA and the plasmid.
Article
Evolutionary Biology
Pauline Schaap, Israel Barrantes, Pat Minx, Narie Sasaki, Roger W. Anderson, Marianne Beinard, Kyle K. Biggar, Nicolas E. Buehler, Ralf Bundschuh, Xiao Chen, Catrina Fronick, Lucinda Fulton, Georg Golderer, Niels Jahn, Volker Knoop, Laura F. Landweber, Chrystelle Maric, Dennis Miller, Angelika A. Noegel, Rob Peace, Gerard Pierron, Taeko Sasaki, Mareike Schallenberg-Ruedinger, Michael Schleicher, Reema Singh, Thomas Spaller, Kenneth B. Storey, Takamasa Suzuki, Chad Tomlinson, John J. Tyson, Wesley C. Warren, Ernst R. Werner, Gabriele Werner-Felmayer, Richard K. Wilson, Thomas Winckler, Jonatha M. Gott, Gernot Gloeckner, Wolfgang Marwan
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Plant Sciences
Mareike Schallenberg-Ruedinger, Bastian Oldenkott, Manuel Hiss, Phuong Le Trinh, Volker Knoop, Stefan A. Rensing
PLANT AND CELL PHYSIOLOGY
(2017)
Article
Biochemical Research Methods
Henning Lenz, Anke Hein, Volker Knoop
BMC BIOINFORMATICS
(2018)
Article
Evolutionary Biology
Anke Hein, Volker Knoop
BMC EVOLUTIONARY BIOLOGY
(2018)
Article
Evolutionary Biology
Anke Hein, Sarah Brenner, Volker Knoop
GENOME BIOLOGY AND EVOLUTION
(2019)
Article
Biochemistry & Molecular Biology
Bernard Gutmann, Santana Royan, Mareike Schallenberg-Ruedinger, Henning Lenz, Ian R. Castleden, Rose McDowell, Michael A. Vacher, Julian Tonti-Filippini, Charles S. Bond, Volker Knoop, Ian D. Small
Article
Plant Sciences
Philipp Gerke, Peter Szovenyi, Anna Neubauer, Henning Lenz, Bernard Gutmann, Rose McDowell, Ian Small, Mareike Schallenberg-Ruedinger, Volker Knoop
Article
Biochemistry & Molecular Biology
Simon Zumkeller, Philipp Gerke, Volker Knoop
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Anke Hein, Sarah Brenner, Monika Polsakiewicz, Volker Knoop
PLANT MOLECULAR BIOLOGY
(2020)
Editorial Material
Plant Sciences
Volker Knoop
PLANT AND CELL PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bastian Oldenkott, Matthias Burger, Anke-Christiane Hein, Anja Joerg, Jennifer Senkler, Hans-Peter Braun, Volker Knoop, Mizuki Takenaka, Mareike Schallenberg-Ruedinger
Article
Biochemistry & Molecular Biology
Elena Lesch, Maximilian T. Schilling, Sarah Brenner, Yingying Yang, Oliver J. Gruss, Volker Knoop, Mareike Schallenberg-Ruedinger
Summary: RNA editing processes differ significantly between animals and plants, with plant PPR proteins playing a key role in plant organelle cytidine-to-uridine editing. It has been discovered that plant PPR editing factors can operate in the nucleo-cytosolic environment of humans and be re-engineered towards new targets.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Plant Sciences
Volker Knoop
Summary: The genomes of plant cells' energy-converting organelles, chloroplasts and mitochondria, have errors that are corrected in RNA transcript copies. The function of genes in these organelles relies on site-specific cytidine-to-uridine (C-to-U) exchanges and additional reverse U-to-C exchanges. Research on these peculiar processes of plant RNA editing has been ongoing for over 30 years. Recent studies have provided insights into the biochemical machinery and the role of horizontal gene transfer in the acquisition and functional adaptation of plant RNA editing factors in other organisms.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Yingying Yang, Bastian Oldenkott, Shyam Ramanathan, Elena Lesch, Mizuki Takenaka, Mareike Schallenberg-Ruedinger, Volker Knoop
Summary: Protein factors for specific RNA editing events in plant mitochondria and chloroplasts have unique RNA-binding PPRs and DYW domains. The function of E1 and E2 motifs in these factors is unclear. In this study, the tolerance of PPR56 and PPR65 for creating chimeras by replacing their C-terminal protein regions was investigated. Results showed that heterologous DYW domains can restrict or widen the spectrum of off-targets in the bacterial transcriptome for PPR56, possibly due to their preference for the immediate sequence of the editing site and long-range impact on upstream PPRs' nucleotide selectivity.
Article
Biology
Bastian Oldenkott, Yingying Yang, Elena Lesch, Volker Knoop, Mareike Schallenberg-Ruedinger
COMMUNICATIONS BIOLOGY
(2019)