Substrate Ambiguous Enzymes within the Escherichia coli Proteome Offer Different Evolutionary Solutions to the Same Problem

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

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Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

(2012) J. Nasvall et al.   SCIENCE

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

(2012) Nobuhiko Tokuriki et al.   Nature Communications

Toward a Systems Biology Perspective on Enzyme Evolution

(2011) Shelley D. Copley   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2011) J. A. G. M. de Visser et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

The JCSG high-throughput structural biology pipeline

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Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Evolution of Bacterial Phosphoglycerate Mutases: Non-Homologous Isofunctional Enzymes Undergoing Gene Losses, Gains and Lateral Transfers

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Recruitment of genes and enzymes conferring resistance to the nonnatural toxin bromoacetate

(2010) K. K. Desai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

(2010) V. W. C. Soo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive Cryptic Epistasis in Molecular Evolution

(2010) Mark Lunzer et al.   PLoS Genetics

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

(2009) Jamie T. Bridgham et al.   NATURE

Origin and evolution of metabolic pathways

(2009) Renato Fani et al.   Physics of Life Reviews

Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity

(2008) Enrique Morett et al.   JOURNAL OF MOLECULAR BIOLOGY

A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

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