Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology

Animal Models of Alzheimer's Disease: Therapeutic Implications

(2017) Diana S. Woodruff-Pak   JOURNAL OF ALZHEIMERS DISEASE

ESCRTing autophagic clearance of aggregating proteins

(2014) Tor Erik Rusten et al.   Autophagy

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family

(2011) S. Anwar et al.   JOURNAL OF NEUROSCIENCE

Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

(2011) Sergey A. Kozin et al.   Molecular BioSystems

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel

(2011) Or A. Shemesh et al.   NEUROBIOLOGY OF DISEASE

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

(2011) J. V. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Hsp33/YOR391Cp from the yeastSaccharomyces cerevisiae

(2010) Peng-Chao Guo et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Broadening the therapeutic scope for rapamycin treatment

(2010) Fiona M. Menzies et al.   Autophagy

Minimal Zn 2+ Binding Site of Amyloid- β

(2010) Philipp O. Tsvetkov et al.   BIOPHYSICAL JOURNAL

Prion-like disorders: blurring the divide between transmissibility and infectivity

(2010) M. Cushman et al.   JOURNAL OF CELL SCIENCE

Should the word ‘dementia’ be forgotten?

(2010) Kurt A. Jellinger   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic Causes of Frontotemporal Degeneration

(2010) Tricia M. See et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

The Genetics of Parkinson Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

LRRK2 and neurodegeneration

(2009) Gabriel Santpere et al.   ACTA NEUROPATHOLOGICA

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

A roadmap for the prevention of dementia II: Leon Thal Symposium 2008

(2009) Zaven S. Khachaturian   Alzheimers & Dementia

Prion Diseases and Their Biochemical Mechanisms†

(2009) Nathan J. Cobb et al.   BIOCHEMISTRY

Cross-β Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements†

(2009) Jillian Madine et al.   BIOCHEMISTRY

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

(2009) Robert J. Ferrante   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modeling familial British and Danish dementia

(2009) Holly J. Garringer et al.   Brain Structure & Function

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

(2009) H. Su et al.   CARDIOVASCULAR RESEARCH

Beyond the Rat Models of Human Neurodegenerative Disorders

(2009) Ondrej Bugos et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The genetics of Parkinson's syndromes: a critical review

(2009) John Hardy et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Neurobiology of cognitive disorders

(2009) Alexander Kurz et al.   CURRENT OPINION IN PSYCHIATRY

Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds

(2009) S. O. Bachurin et al.   Doklady Biochemistry and Biophysics

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models

(2009) Makiko Yamashita et al.   FEBS LETTERS

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

(2009) Natalia Ninkina et al.   HUMAN MOLECULAR GENETICS

TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases

(2009) Yohei Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases

(2009) Felix Geser et al.   JOURNAL OF NEUROLOGY

Assessment of α-Synuclein Pathology: A Study of the BrainNet Europe Consortium

(2009) Irina Alafuzoff et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

(2009) J. L. Wacker et al.   JOURNAL OF NEUROSCIENCE

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?

(2009) Vladimir L. Buchman et al.   NEUROTOXICITY RESEARCH

Versatile Somatic Gene Transfer for Modeling Neurodegenerative Diseases

(2009) Ronald L. Klein et al.   NEUROTOXICITY RESEARCH

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

(2008) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Polymorphism in an Amyloid‐Like Fibril‐Forming Model Peptide

(2008) René Verel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isomerization of the Asp7 Residue Results in Zinc‐Induced Oligomerization of Alzheimer’s Disease Amyloid β(1–16) Peptide

(2008) Philipp O. Tsvetkov et al.   CHEMBIOCHEM

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience

(2008) Gabor G. Kovacs et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

(2008) Steven L. Senior et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TDP-43 in neurodegenerative disorders

(2008) Casey Cook et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The Molecular Basis of Functional Bacterial Amyloid Polymerization and Nucleation

(2008) Xuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Modeling synucleinopathies in genetically modified animals: Successes and failures

(2008) N. N. Ninkina et al.   MOLECULAR BIOLOGY

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

Aggregopathy in Neurodegenerative Diseases: Mechanisms and Therapeutic Implication

(2008) C.P. Dohm et al.   Neurodegenerative Diseases