Article
Neurosciences
Abhishek Pethe, Mira Hamze, Marina Giannaki, Bernd Heimrich, Igor Medina, Anna-Maria Hartmann, Eleni Roussa
Summary: This study investigates the effects of KCC2/NBCe1 interaction on the phosphorylation pattern and function of KCC2. The results show that KCC2 and NBCe1 interact in the mouse brain and this interaction may have pathophysiological relevance.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Andree-Anne Marcoux, Laurence E. Tremblay, Samira Slimani, Marie-Jeanne Fiola, Fabrice Mac-Way, Alexandre P. Garneau, Paul Isenring
Summary: NKCC2 is an integral membrane protein that mediates the cotranslocation of Na+, K+, and Cl(-) ions in the TALH, allowing for the reclamation of a large fraction of filtered Na+, Cl-, Ca2+, Mg-2(+), and HCO(3)(-). Malfunction of NKCC2 can lead to various inherited disorders, illustrating its physiological importance.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Chuanming Xu, Yanting Chen, Fei Wang, Shiying Xie, Tianxin Yang
Summary: This study reveals a novel mechanism by which PRR and sPRR negatively regulate NCC activity through S1P, impacting renal excretion of salt and potassium and thus modulating blood pressure and potassium balance.
Article
Physiology
Xin-Peng Duan, Peng Wu, Dan-Dan Zhang, Zhong-Xiuzi Gao, Yu Xiao, Evan C. Ray, Wen-Hui Wang, Dao-Hong Lin
Summary: Kir5.1 plays a significant role in mediating the effect of high sodium intake on basolateral K+ channels in the distal convoluted tubule and Na+-Cl- cotransporter activity/expression, and is involved in maintaining renal ability of K+ excretion during high sodium intake.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nur Farah Meor Azlan, Maarten P. Koeners, Jinwei Zhang
Summary: Hypertension, the leading cause of cardiovascular disease mortality worldwide, has been linked to alterations in the NCC and its regulatory mechanisms. Recent research has revealed significant progress in understanding the control of NCC, potentially identifying novel therapeutic targets for hypertension.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Neurosciences
Jesper Edvardsson Rasmussen, Patrik Lundstrom, Per Olof Eriksson, Helge Rask-Andersen, Wei Liu, Goran Laurell
Summary: This study aimed to understand the acute effects of furosemide in the inner ear, including protein localization. The results showed rapid changes in NKCC1 induced by furosemide, and an increase in staining intensity of Fetuin-A and PEDF, possibly as an otoprotective response.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
A. Barany, C. A. Shaughnessy, R. M. Pelis, J. Fuentes, J. M. Mancera, S. D. McCormick
Summary: Two orthologues of the gene encoding the Na+-Cl- cotransporter (NCC), termed ncca and nccb, were found in the sea lamprey genome. The NCCs occupied basal positions within the NCC clades in a phylogenetic comparison among other vertebrate NCC and NKCC sequences. nccb is likely the key ion cotransport protein for ion uptake by the lamprey intestine that facilitates water absorption in seawater.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Sun
Summary: HMGB1 promotes the expression of NKCC1 and NHE1 in astrocytes and endothelial cells through activation of the HMGB1-TLR4-TRIF-NF-kappa B signaling pathway, leading to cytotoxic and ionic edema following spinal cord injury. Inhibition of HMGB1 reduces the expression of NKCC1 and NHE1 and decreases spinal cord edema. These findings are important for understanding the regulation of spinal cord edema after injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Physiology
Alexander M. Clifford, Martin Tresguerres, Greg G. Goss, Chris M. Wood
Summary: During exposure to acidic water, zebrafish utilize a novel mechanism of Na+ uptake that relies on the outwardly directed K+ gradient as a counter-substrate for Na+ and is sensitive to tetraethylammonium (TEA).
Article
Physiology
Jason P. Breves, Ian S. McKay, Victor Koltenyuk, Nastasia N. Nelson, Sean C. Lema, Stephen D. McCormick
Summary: The life history of Atlantic salmon involves a migration from freshwater to marine environments, and the development of osmoregulatory systems, including Na+/HCO3- cotransporter 1 (Nbce1), is crucial for their survival. This study investigated the expression of three isoforms of Nbce1 in the gills and intestine of salmon. The results suggest that tissue-specific modulation of Nbce1 isoforms contributes to the adaptive responses to seawater exposure in salmon.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Zhong-Xiuzi Gao, Qi-Chao Wei, Ting-Ting Shu, Shu-Ting Li, Rui Zhou, Ming-Yan Li, Zi-Hui Mao, Dong-Wei Liu, Zhang-Suo Liu, Peng Wu
Summary: This study found that high salt intake in early streptozotocin-induced diabetes leads to imbalanced Na+/K+ ratio, increased blood pressure, and enhanced NCC activity. These effects are associated with increased expression and activity of Kir4.1 in the distal convoluted tubule (DCT). Additionally, the study suggests that Kir4.1 deletion prevents the upregulation of NCC and the development of salt-sensitive hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Yoshihiko Yamazaki, Yoshifumi Abe, Satoshi Fujii, Kenji F. Tanaka
Summary: Researchers have found that NKCC1 regulates oligodendrocyte activity in juvenile mice, promoting neuronal plasticity, and overexpression of NKCC1 in adulthood can restore neuronal plasticity.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Tirumalesh Keesari, Saha Dauji
Summary: Despite the popularity of correlation plots for interpreting the causes of groundwater salinization, this study found that spurious correlations may exist and caution is advised. Using qualitative and quantitative tools, the study demonstrated the presence of spurious correlations and proposed an efficient detection method.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Review
Pharmacology & Pharmacy
Michael Tagen, Linda E. Klumpers
Summary: This review summarizes the pharmacological studies of Delta-8-tetrahydrocannabinol (Delta(8)-THC), including receptor binding, cannabimimetic activity, and pharmacokinetics. The findings suggest that Delta(8)-THC has similar pharmacokinetics and pharmacodynamics to Delta(9)-THC, but lower affinity for the cannabinoid CB1 receptor. The reduced potency of Delta(8)-THC in clinical studies compared to Delta(9)-THC may be explained by this weaker affinity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Ying Shi, Pengju Wang, Wenliang Li, Yan Su
Summary: A comprehensive genetic algorithm is used to search for Cl-(H2O)(1-9) and NaCl(H2O)(1-9), and various properties of these systems are investigated. It is found that the introduction of Na+ stabilizes the ionic hydrogen bonds in Cl-(H2O)(n), while the introduction of Cl- weakens the interactions between Na+ and H2O in Na+(H2O)(n). The structures of NaCl(H2O)(n) obtained from the genetic algorithm correspond to contact ion pairs, and solvent-separated ion pair structures appear when n = 7. The infrared spectra analysis shows good agreement with experimental results, and charge analysis reveals the charge transfer from Cl- to H2O in NaCl(H2O)(n).
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Natascha Pigat, Edouard Reyes-Gomez, Florence Boutillon, Stefano Palea, Nicolas Barry Delongchamps, Egon Koch, Vincent Goffin
FRONTIERS IN PHARMACOLOGY
(2019)
Correction
Multidisciplinary Sciences
Tristan J. M. Goncalves, Florence Boutillon, Suzie Lefebvre, Vincent Goffin, Takeshi Iwatsubo, Tomoko Wakabayashi, Franck Oury, Anne-Sophie Armand
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Candler Paige, Priscilla A. Barba-Escobedo, Jennifer Mecklenburg, Mayur Patil, Vincent Goffin, David R. Grattan, Gregory Dussor, Armen N. Akopian, Theodore J. Price
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Virginie Grouthier, Zeina Chakhtoura, Isabelle Tejedor, Yasmina Badachi, Vincent Goffin, Philippe Touraine
ENDOCRINE CONNECTIONS
(2020)
Article
Clinical Neurology
Amanda Avona, Bianca N. Mason, Carolina Burgos-Vega, Anahit H. Hovhannisyan, Sergei N. Belugin, Jennifer Mecklenburg, Vincent Goffin, Naureen Wajahat, Theodore J. Price, Armen N. Akopian, Gregory Dussor
Summary: This study found an interaction between prolactin and CGRP in the meninges of rodents, leading to female-specific migraine behaviors, potentially explaining the higher prevalence of migraines in women.
ANNALS OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Nicolas Barry Delongchamps, Alexandre Schull, Julien Anract, Jean-Paul Abecassis, Marc Zerbib, Mathilde Sibony, Lea Jilet, Hendy Abdoul, Vincent Goffin, Michael Peyromaure
Summary: This study evaluated the feasibility, safety, and precision of OBT-fusion targeted FMA in patients with low to intermediate risk prostate cancer. The results showed that this method achieved good ablation outcomes in the majority of patients, with no significant deterioration in urinary and sexual function post-operatively.
Article
Biochemistry & Molecular Biology
Anju Dwivedi, Chiranjeevi Padala, Anita Kumari, Saratchandra Singh Khumukcham, Vasudevarao Penugurti, Sinjini Ghosh, Aprotim Mazumder, Vincent Goffin, Bramanandam Manavathi
Summary: This study identified HPIP as a critical regulator of PRL signaling in lactogenic differentiation of mammary epithelial cells, involving multiple pathways such as PI3K/AKT and miR-148a, which control the differentiation process.
Review
Urology & Nephrology
Manon Baures, Charles Dariane, Elisavet Tika, Emilia Puig Lombardi, Nicolas Barry Delongchamps, Cedric Blanpain, Jacques-Emmanuel Guidotti, Vincent Goffin
Summary: This review paper summarizes various approaches used to characterize luminal progenitor cells in the prostate and discusses their functional properties and potential role in prostate pathology. The authors also describe different methods and identifiers used to classify these cells.
NATURE REVIEWS UROLOGY
(2022)
Article
Immunology
Jennifer Mecklenburg, Andi Wangzhou, Anahit H. Hovhannisyan, Priscilla Barba-Escobedo, Sergey A. Shein, Yi Zou, Korri Weldon, Zhao Lai, Vincent Goffin, Gregory Dussor, Alexei Tumanov, Theodore J. Price, Armen N. Akopian
Summary: This study developed pain models with sex-dependent resolution trajectories and identified factors associated with the resolution of pain in males and females. The results showed that different treatment protocols with prolactin (PRL) can lead to distinct pain development and resolution patterns, with acute PRL-evoked pain fully resolved within one day and prolonged high dose PRL treatment causing mechanical hypersensitivity that resolves within 5-7 days. Furthermore, pro-inflammatory responses in the hindpaws, particularly with macrophages/monocytes, were observed during pain resolution in both sexes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Oncology
Charles Dariane, Sylvie Clairefond, Benjamin Peant, Laudine Communal, Zhe Thian, Veronique Ouellet, Dominique Trudel, Nazim Benzerdjeb, Feryel Azzi, Arnaud Mejean, Marc-Olivier Timsit, Manon Baures, Jacques-Emmanuel Guidotti, Vincent Goffin, Pierre I. Karakiewicz, Anne-Marie Mes-Masson, Fred Saad
Summary: Keratin-7 overexpression is associated with poor prognosis in several cancers, and its high expression in benign glands surrounding localized prostate tumors is correlated with shorter bone metastasis-free survival and increased risk of cancer-specific mortality. In prostate cancer patients, high Keratin-7 expression is significantly associated with hypertrophic basal cell phenotype.
Article
Oncology
Manon Baures, Emilia Puig Lombardi, Delphine Di Martino, Wail Zeitouni, Emeline Pacreau, Leila Dos Santos, Charles Dariane, Florence Boutillon, Jacques-Emmanuel Guidotti, Vincent Goffin
Summary: The study identified LSCmed cells as matching human prostate Club/Hillock cells, regulated by EGFR/ERBB4, IGF-1 and MET pathways, and exhibiting drug resistance. These cells are considered a relevant preclinical model for investigating the cellular and molecular mechanisms driving CRPC.
Article
Oncology
Maite Verreault, Irma Segoviano Vilchis, Shai Rosenberg, Nolwenn Lemaire, Charlotte Schmitt, Jeremy Guehennec, Louis Royer-Perron, Jean-Leon Thomas, TuKiet T. Lam, Florent Dingli, Damarys Loew, Francois Ducray, Sophie Paris, Catherine Carpentier, Yannick Marie, Florence Laigle-Donadey, Audrey Rousseau, Natascha Pigat, Florence Boutillon, Franck Bielle, Karima Mokhtari, Stuart J. Frank, Aurelien de Reynies, Khe Hoang-Xuan, Marc Sanson, Vincent Goffin, Ahmed Idbaih
Summary: This study identifies a distinct molecular subset of GBMs that is characterized by GHR signaling instead of EGFR overexpression. GHR signaling promotes tumorigenesis and regulates cell proliferation and migration, providing a new direction for improving the prognosis of GBM patients.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Oncology
Laura Cheradame, Ida Chiara Guerrera, Julie Gaston, Alain Schmitt, Vincent Jung, Marion Pouillard, Nina Radosevic-Robin, Mauro Modesti, Jean-Gabriel Judde, Vincent Goffin, Stefano Cairo
Meeting Abstract
Oncology
Laura Cheradame, Chiara Guerrera, Jean-Gabriel Judde, Vincent Goffin, Stefano Cairo
Article
Developmental Biology
A. Olmos-Ortiz, M. Deciga-Garcia, E. Preciado-Martinez, L. Bermejo-Martinez, P. Flores-Espinosa, I. Mancilla-Herrera, C. Irles, A. C. Helguera-Repetto, B. Quesada-Reyna, V. Goffin, L. Diaz, V. Zaga-Clavellina
MOLECULAR HUMAN REPRODUCTION
(2019)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)