Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Suvadeep Mal, Ashish Ranjan Dwivedi, Vijay Kumar, Naveen Kumar, Bhupinder Kumar, Vinod Kumar
Summary: PPAR, as a crucial transcription factor, plays a significant role in regulating various disease states, especially in cancer growth and metabolism. However, known PPAR ligands often lead to severe side effects. Therefore, the current focus is on developing novel PPAR ligands with little to no adverse effects.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chaitra Rai, C. D. Nandini, Poornima Priyadarshini
Summary: The study demonstrated the anti-adipogenic activity of bovine milk Glycosaminoglycans (bmGAGs) by modulating adipogenesis-related marker proteins, suggesting a potential therapeutic use of bmGAGs in the management of obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Cell Biology
Yaqin Zhao, Huabing Tan, Xiaoyu Zhang, Jing Zhu
Summary: This article summarizes the role of PPARs in the occurrence and development of HCC, as well as their value in the diagnosis, treatment, and prognosis of HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Jiyoung Bae, Yang Yang, Xinyun Xu, Jamie Flaherty, Haley Overby, Kelsey Hildreth, Jiangang Chen, Shu Wang, Ling Zhao
Summary: Identifying functional brown adipose tissue (BAT) has provided new hope for obesity treatment and prevention. The study found that naringenin (NAR) can promote adipocyte browning and thermogenesis through the activation of PPARγ.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xingren Chen, Xiaobo Zhu, Jian Dong, Fang Chen, Qi Gao, Lijun Zhang, Dawei Cai, Hui Dong, Binjia Ruan, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: The study demonstrates that diacerein has a significant protective effect on cartilage damage in OA mice, by inhibiting the upregulation of DNMT1/3a, promoter hypermethylation of PPAR gamma, and reversing the expression of antioxidant enzymes and inflammatory cytokines.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Respiratory System
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bolling, Danay Maestre-Batlle, Christopher F. Rider, Anke Huls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Summary: This study investigates how SNPs in PPARG and oxidative stress genes modify the impact of DBP exposure on lung function and immune responses. The results suggest that variants in PPARG play a greater role in airway allergic responses to DBP than oxidative stress-related genes.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhijun He, Xiaoqian Li, Zi Wang, Yingqi Cao, Shuangxue Han, Nan Li, Jie Cai, Shuiyuan Cheng, Qiong Liu
Summary: This study revealed the beneficial effects of luteolin on Alzheimer's disease through inhibiting Aβ generation, repairing mitochondrial damage, and reducing neuronal apoptosis. The mechanism involved the binding of luteolin to PPARγ to promote its expression and function.
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Correction
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: The study found that HMGB1 is an independent risk factor for carotid plaque vulnerability in diabetic patients, with higher levels of HMGB1 and inflammatory cytokines in ICAS patients compared to WICAS patients. Among ICAS patients, those with unstable plaque had even higher levels of these cytokines. HMGB1 and osteoprotegerin were independently associated with unstable plaque in ICAS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessandro Maino, Enrico Di Stasio, Maria Chiara Grimaldi, Luigi Cappannoli, Erica Rocco, Rocco Vergallo, Federico Biscetti, Silvia Baroni, Andrea Urbani, Raffaele Landolfi, Luigi Marzio Biasucci
Summary: This study found that 16% of COVID-19 patients had myocardial injury, with older patients with more cardiovascular comorbidities and higher inflammatory markers being more likely to experience cardiac injury. Patients with myocardial injury had significantly higher rates of hospitalization and mortality, with Hs-TnI testing able to predict disease severity and patient risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Letter
Medicine, General & Internal
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Fabio Pilato, Iacopo Valente, Rosalinda Calandrelli, Andrea Alexandre, Vincenzo Arena, Marco Dell'Aquila, Aldobrando Broccolini, Giacomo Della Marca, Roberta Morosetti, Giovanni Frisullo, Valerio Brunetti, Marisa Distefano, Alessandro Pedicelli, Cesare Colosimo, Vincenzo Di Lazzaro
Summary: This study aimed to predict distal embolization during thrombectomy by evaluating thrombus features and patient-related features. The study found that the combined effect of anticoagulant therapy and thrombus length may have a harmful impact on reperfusion, causing distal embolization.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Federica Rubbino, Valentina Garlatti, Valeria Garzarelli, Luca Massimino, Salvatore Spano, Paolo Iadarola, Maddalena Cagnone, Martin Giera, Marieke Heijink, Simone Guglielmetti, Vincenzo Arena, Alberto Malesci, Luigi Laghi, Silvio Danese, Stefania Vetrano
Summary: This study highlights the role of GPR120 in the progression of colorectal cancer. Loss of GPR120 in the gut leads to increased intestinal permeability, microbiota translocation, and dysbiosis, which results in hyperproliferation of epithelial cells through the activation of beta-catenin signaling. Therefore, the loss of GPR120 is an early event in CRC development but does not promote invasive cancer.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Silvia Giovannini, Federico Biscetti, Fabrizio Brau, Lorenzo Biscotti, Angelo Santoliquido, Dario Pitocco, Roberto Bernabei, Andrea Flex
Summary: The ratio of sortilin to omentin-1 may be a predictive factor for peripheral artery disease (PAD) in patients with type-2 diabetes, and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Biochemistry & Molecular Biology
Enrica Rossini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Maria Anna Nicolazzi, Marcello Covino, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality in high-income countries, although its impact is decreasing. Statins are effective in reducing LDL cholesterol and the risk of mortality, but are under-prescribed or under-dosed due to concerns about side effects. Personalized treatment decisions should be made based on individual considerations and shared decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Leonardo Cecchini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Giovanni Pecorini, Luis H. Eraso, Paul J. Dimuzio, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: This article discusses the interplay between nutrition and the development/progression of PAD, summarizing the current research on dietary risk factors and their impact on PAD. It also explores the effects of dietary patterns and eating disorders on PAD and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Giuseppe De Matteis, Federico Biscetti, Davide Antonio Della Polla, Amato Serra, Maria Livia Burzo, Mariella Fuorlo, Maria Anna Nicolazzi, Angela Novelli, Angelo Santoliquido, Giovanni Gambassi, Antonio Gasbarrini, Andrea Flex, Francesco Franceschi, Marcello Covino
Summary: This study aimed to describe sex-based differences in clinical characteristics and outcomes among hospitalized patients affected by peripheral arterial disease (PAD). The study found that although there were some differences between sexes among PAD patients, gender did not significantly affect the occurrence of major adverse cardiovascular events (MACEs) and major adverse limb events (MALEs). However, among these patients, males were more likely to experience adverse clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrea Leonardo Cecchini, Federico Biscetti, Matteo Manzato, Lorenzo Lo Sasso, Maria Margherita Rando, Maria Anna Nicolazzi, Enrica Rossini, Luis H. Eraso, Paul J. Dimuzio, Massimo Massetti, Antonio Gasbarrini, Andrea Flex
Summary: This paper provides a literature review on pharmacotherapy for peripheral artery disease (PAD), focusing on the effects of different drug classes on inflammatory pathways. The study found that current treatments have anti-inflammatory properties that can potentially delay or prevent progression of PAD and improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Federico Biscetti, Andrea Leonardo Cecchini, Maria Margherita Rando, Elisabetta Nardella, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: This study reviewed the main risk factors of major adverse limb events in peripheral artery disease among diabetic patients, aiming to propose a new predictive tool to prevent disabling vascular complications of the disease.
ATHEROSCLEROSIS PLUS
(2021)
Letter
Surgery
A. Oliva, S. Grassi, N. Minelli, M. Zedda, V. Arena, N. Romaniello, G. Dionigi, O. Makay, C. De Crea, S. Celik, A. Gioacchino Spagnolo, R. Bellantone, M. Raffaelli
Summary: This article discusses the use of transoral endoscopic thyroidectomy by a vestibular approach on cadavers as a means to enhance both the technical and non-technical skills of surgeons.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
