Review
Medicine, Research & Experimental
Zhimei Peng, Yanting Liang, Xueying Liu, Jie Shao, Nan Hu, Xinzhou Zhang
Summary: This review discusses the clinical relevance of circadian rhythms in diabetic kidney disease (DKD) and the functions of the core clock gene BMAL1 in DKD. It also explores the potential mechanisms of Bmal1 and its signaling pathways in DKD, as well as outlines potential intervention strategies for DKD circadian rhythm disturbance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Behavioral Sciences
Jacob R. Bumgarner, William H. Walker, Randy J. Nelson
Summary: The circadian rhythms of pain are not produced by a single locus, but are a complex result of distributed rhythms throughout the pain system and interacting systems, including the opioid, endocrine, and immune systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Paula M. Wagner, Cesar G. Prucca, Beatriz L. Caputto, Mario E. Guido
Summary: Gliomas are solid tumors of the central nervous system classified into four groups by malignancy, with GBM being the most common and aggressive type. Current therapies for GBM have limited efficacy, prompting exploration of the potential role of the circadian clock in tumor cell modulation as a new target for novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Pritha Dutta, Mehrshad Sadria, Anita T. Layton
Summary: Sex differences in renal function and blood pressure have been observed across many species. Kidney function and blood pressure exhibit diurnal rhythms, which are regulated by circadian clock genes. This study aimed to assess the effects of sex and administration time on the natriuretic and diuretic effects of diuretics commonly used to treat hypertension. Computational models of mouse kidney function were used to simulate the effects of diuretics on sodium transport. The results showed significant sex and time-of-day differences in the drug response, indicating the importance of considering these factors in optimizing drug efficacy.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa
Summary: Deficiency of SIK3 in GABAergic neurons or NMS-producing neurons delays the arousal peak phase, while a gain-of-function mutant allele of Sik3 in GABAergic neurons advances the activity onset. Furthermore, HDAC4 deficiency shortens the circadian cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Soo Ji Kim, Chris Chi, Gopal Pattanayak, Aaron R. Dinner, Michael J. Rust
Summary: By studying the cyanobacterial clock, a new protein called KidA was discovered to interact with the clock and shorten its period. It was also found that KidA alters the clock's ability to entrain to light-dark cycles. These findings reveal that the period and amplitude of the clock can be modulated by regulating the access of KaiB to the fold-switched form.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Plant Sciences
Elaine Tobin
Summary: The author, a successful woman in the field of science, was motivated by her family background to pursue education and adventure, which led to strong support and accomplishments in her career. She not only had an interest in science, but also a strong interest and involvement in politics.
ANNUAL REVIEW OF PLANT BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Shuhui Jia, Xuantong Guo, Zuxin Chen, Shupeng Li, Xin-an Liu
Summary: Given the devastating social and health consequences of drug addiction and the limitations of current treatments, a new strategy involving correcting abnormal circadian rhythms and improving sleep quality may be beneficial in the treatment of drug addiction. Melatonin, a circadian hormone with various neuroprotective and pharmacological effects, has shown potential as an intervention for substance use disorders. This review discusses the roles of melatonin at different levels and its potential applications in drug addiction.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Julie C. Lim, Haruna Suzuki-Kerr, Tai X. Nguyen, Christopher J. J. Lim, Raewyn C. Poulsen
Summary: Accumulating evidence suggests an interconnection between circadian clocks and redox regulation. With advancing age, the depletion of the antioxidant glutathione (GSH) in the lens leads to the development of age-related cataracts. Understanding the mechanisms involved in regulating GSH levels may lead to the future development of approaches to protect the lens.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Zoha Akbar, Zumin Shi
Summary: This study aimed to evaluate the associations between dietary patterns and circadian syndrome (CircS). Two major dietary patterns were identified, with the Western pattern positively associated with CircS and the prudent pattern inversely associated with CircS.
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Urology & Nephrology
Natsuko Tokonami, Tomoaki Takata, Jan Beyeler, Iris Ehrbar, Ayumi Yoshifuji, Erik I. Christensen, Johannes Loffing, Olivier Devuyst, Eric G. Olinger
KIDNEY INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Beatrice Paola Festa, Zhiyong Chen, Marine Berquez, Huguette Debaix, Natsuko Tokonami, Jenny Ann Prange, Glenn van de Hoek, Cremonesi Alessio, Andrea Raimondi, Nathalie Nevo, Rachel H. Giles, Olivier Devuyst, Alessandro Luciani
NATURE COMMUNICATIONS
(2018)
Article
Physiology
Anne Ruiz, Ivan Gautschi, Laurent Schild, Olivier Bonny
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Urology & Nephrology
Claus D. Schuh, Marcello Polesel, Evgenia Platonova, Dominik Haenni, Alkaly Gassama, Natsuko Tokonami, Susan Ghazi, Milica Bugarski, Olivier Devuyst, Urs Ziegler, Andrew M. Hall
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Urology & Nephrology
Natsuko Tokonami, Eric Olinger, Huguette Debaix, Pascal Houillier, Olivier Devuyst
KIDNEY INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Eric Olinger, Jennifer Lake, Susan Sheehan, Guglielmo Schiano, Tomoaki Takata, Natsuko Tokonami, Huguette Debaix, Francesco Consolato, Luca Rampoldi, Ron Korstanje, Olivier Devuyst
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Alessandro Luciani, Anke Schumann, Marine Berquez, Zhiyong Chen, Daniela Nieri, Mario Failli, Huguette Debaix, Beatrice Paola Festa, Natsuko Tokonami, Andrea Raimondi, Alessio Cremonesi, Diego Carrella, Patrick Forny, Stefan Koelker, Francesca Diomedi Camassei, Francisca Diaz, Carlos T. Moraes, Diego Di Bernardo, Matthias R. Baumgartner, Olivier Devuyst
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Matthias B. Moor, Suresh K. Ramakrishnan, Finola Legrand, Matthias Bachtler, Robert Koesters, Nancy E. Hynes, Andreas Pasch, Olivier Bonny
Article
Respiratory System
Cecile Daccord, Jean-Marc Good, Marie-Anne Morren, Olivier Bonny, Daniel Hohl, Romain Lazor
EUROPEAN RESPIRATORY REVIEW
(2020)
Article
Transplantation
Dusan Harmacek, Anne Blanchard, Gregoire Wuerzner, Marc Maillard, Xavier Jeunemaitre, Michel Azizi, Olivier Bonny
Summary: During a high-Na/low-K diet, amiloride exhibits a strong acute hypocalciuric effect, most likely mediated by increased proximal tubular calcium reabsorption.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Letter
Urology & Nephrology
Dusan Harmacek, Menno Pruijm, Michel Burnier, Marie-Eve Muller, Arlene Ghajarzadeh-Wurzner, Olivier Bonny, Anne Zanchi
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Daniela Cabuzu, Suresh K. Ramakrishnan, Matthias B. Moor, Dusan Harmacek, Muriel Auberson, Fanny Durussel, Olivier Bonny
Summary: This study validated the increased expression of Ecrg4 gene in hypercalciuric mouse models and described its expression along the nephron. By conducting experiments on Ecrg4 knockout mice, it was found that Ecrg4 may modulate renal crystallization and provide new therapeutic possibilities against calcium oxalate nephropathy.
Review
Urology & Nephrology
Constance Legay, Tropoja Krasniqi, Alice Bourdet, Olivier Bonny, Murielle Bochud
Summary: This scoping review examines the methods used to study the diet of adult kidney stone formers. The study found that food frequency questionnaires and other questionnaires were the most commonly used methods, while new technologies were rarely used. Assessing long-term dietary intake remains a challenge.
JOURNAL OF NEPHROLOGY
(2022)
Article
Physiology
Matthias B. Moor, Olivier Bonny
PHYSIOLOGICAL REPORTS
(2020)
Article
Physiology
Aarelie Edwards, Olivier Bonny
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)