Article
Pharmacology & Pharmacy
Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Wei Wang, Yongquan Chen, Shenglong Zhu
Summary: This study found that Apol9a regulates myogenic differentiation via the ERK1/2 pathway, providing a promising therapeutic target for intervention in obesity and obesity-induced muscle atrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Trang Thi Huyen Dang, Jong Won Yun
Summary: BMP10 plays crucial roles in muscle physiology by promoting myogenic differentiation, glucose uptake, and lipid catabolism, mainly via the Smad 1/5/8 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Shion Osana, Yasuo Kitajima, Suzuki Naoki, Kazutaka Murayama, Hiroaki Takada, Ayaka Tabuchi, Yutaka Kano, Ryoichi Nagatomi
Summary: Skeletal muscle maintenance relies on muscle stem cells that provide myoblasts for muscle regeneration and growth. Proteasome dysfunction in skeletal muscle impairs muscle growth and development. Aminopeptidase inhibition affects the proliferation and differentiation ability of C2C12 myoblasts. Knockdown of different aminopeptidases in C2C12 myoblasts results in defective myogenic differentiation, except for leucine aminopeptidase 3 (LAP3) which promotes myogenic differentiation. Knockdown of LAP3 inhibits proteasomal proteolysis, decreases branched-chain amino acid levels, and enhances mTORC2-mediated AKT phosphorylation to promote myogenic differentiation through increased expression of myogenin.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Xiaojing Zhang, Huiqin Bian, Wei Wei, Qian Wang, Jinnan Chen, Ruoxuan Hei, Chen Chen, Xuan Wu, Haochun Yuan, Junxia Gu, Yaojuan Lu, Cheguo Cai, Qiping Zheng
Summary: DLX5 plays essential roles in bone development and oncogenesis. This study investigated its effect on osteosarcoma progression, revealing that DLX5 promotes OS cell growth and progression, potentially through activation of the NOTCH signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Jana Uhlirova, Lenka Sebestova, Karel Fiser, Tomas Sieger, Jindriska Fiserova, Pavel Hozak
Summary: The nucleoporin TPR plays a crucial role in the regulation of genes related to muscle formation and function and has been shown to affect the morphology of myoblasts and myotubes. However, more evidence is needed to fully understand how TPR specifically influences the expression of myogenic genes.
Article
Biochemistry & Molecular Biology
Shengfang Wang, Lan Xiao, Indira Prasadam, Ross Crawford, Yinghong Zhou, Yin Xiao
Summary: The study found that stimulation by M1 macrophages leads to the retention of osteocytes in an immature stage, characterized by a more rounded morphology, higher expression of early osteocyte marker E11, and significantly lower expression of mature osteocyte marker DMP1. Immature osteocytes were also observed in areas of inflammatory bone remodeling, exhibiting altered morphology and mineralized structures similar to those induced by M1 macrophages in vitro. The Notch signaling pathway was downregulated in M1-stimulated osteocytes and osteocytes in inflammatory bone, with overexpression of the pathway mitigating the negative effects of M1 macrophages.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yan Chen, Yuan Ma, Jin Jin Feng, Yi He Wang, Tian Fang Li, Katariina Nurmi, Kari K. Eklund, Jian Guo Wen
Summary: The study found that H3R signaling pathway regulates the effects of TNF-α on C2C12 myocyte differentiation and activation of NLRP3 inflammasome. By modulating H3R activity, muscle inflammation and atrophy can be limited.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aika Sawada, Takuya Yamamoto, Takahiko Sato
Summary: Exosomes in serum can inhibit the differentiation of myogenic cells, which is associated with the downregulation of Tceal5 and Tceal7 genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jing Zhang, Naiwen Zhang, Jianfeng Lei, Bin Jing, Mengyuan Li, Huiling Tian, Bing Xue, Xiaoli Li
Summary: Fluoxetine exhibits neuroprotective effects in relieving LPS-induced depression-like and motor behaviors. The underlying mechanisms may involve inhibiting microglial activation, regulating the Notch signaling pathway, and inhibiting the inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Young-Woo Jo, Inkuk Park, Kyusang Yoo, Hyun-Young Woo, Ye Lynne Kim, Yea-Eun Kim, Ji-Hoon Kim, Young-Yun Kong
Summary: This study found that Notch1 and Notch2 play distinct roles in maintaining the population of myogenic progenitors (MPs) during fetal myogenesis, with Notch1 inducing cell cycle exit and Notch2 suppressing premature differentiation. The activation of Notch1 and Notch2 signaling in MPs is also shown to be distinctively regulated by interactions with Notch ligand-expressing myofibers and MP-lineage cells, respectively.
Article
Pharmacology & Pharmacy
Miguel Marco-Bonilla, Raquel Herencia, Maria Fresnadillo, Fernando Huete-Toral, Gonzalo Carracedo, Raquel Largo, Gabriel Herrero-Beaumont, Aranzazu Mediero
Summary: This study examines the role of the purinergic system in muscle myogenesis and the potential therapeutic approach of dipyridamole in sarcopenia. The results show that the blockade of ATP release promotes premature myogenesis, while dipyridamole counteracts this effect through the adenosine A2B receptor and cAMP/AMPK pathways. These findings provide insights into the mechanisms of muscle development and suggest dipyridamole as a potential treatment for sarcopenia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jiuyan Zhang, Yuan Zhao, Ning Sun, Manyu Song, Yongping Chen, Lin Li, Hailin Cui, Haotian Yang, Chuqiao Wang, Haiyang Zhang, Honggang Fan
Summary: This study reveals that lycopene (LYC) can alleviate spleen injury induced by chronic stress. LYC reduces splenocyte apoptosis and immunosuppression by inhibiting the death receptor apoptotic pathway and Notch pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Yongguang Gao, Zhanda Fu, Junxia Guan, Xinhua Liu, Qing Zhang
Summary: Metabolic bone diseases are the third most common endocrine disorders, affecting over 500 million people worldwide. The Notch signaling pathway plays a crucial role in the development and regulation of bone metabolic diseases. Genetic mutations in Notch signaling genes can lead to various metabolic bone diseases. This review provides insights into the mechanisms and clinical manifestations of these diseases, aiming to raise awareness and offer new approaches for diagnosis and treatment of metabolic bone diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ling Li, Siyu Li, Zhifan Pan, Yan Zhang, Ziyu Hua
Summary: This study reveals the significance of microglial autophagy in the pathogenesis of bilirubin encephalopathy. Bilirubin reduces the level of microglial autophagy and promotes neuroinflammatory responses. Enhancing microglial autophagy can attenuate the inflammatory response caused by bilirubin and improve prognosis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Yan Li, Jianhua Wang, Chengzhen Gao, Qiyan Hu, Xiaogang Mao
Summary: ITM2A is downregulated in cervical tumor tissues and associated with poor survival; Overexpression of ITM2A increases the sensitivity of cervical cancer cells to cisplatin; ITM2A may mediate cisplatin-resistant cervical cancer through the Notch signaling pathway.
Article
Biochemistry & Molecular Biology
Bilal Al Jaam, Katy Heu, Florian Pennarubia, Alexandre Segelle, Laetitia Magnol, Agnes Germot, Sebastien Legardinier, Veronique Blanquet, Abderrahman Maftah
Article
Biochemistry & Molecular Biology
Melanie Pelisse, Audrey Der Vartanian, Agnes Germot, Abderrahman Maftah
DNA AND CELL BIOLOGY
(2018)
Article
Urology & Nephrology
Monika Wnuk, Ruslan Hlushchuk, Mathilde Janot, Gerald Tuffin, Georg Martiny-Baron, Philipp Holzer, Patricia Imbach-Weese, Valentin Djonov, Uyen Huynh-Do
KIDNEY INTERNATIONAL
(2012)
Article
Endocrinology & Metabolism
Mathilde Janot, Marie-Laure Cortes-Dubly, Stephane Rodriguez, Uyen Huynh-Do
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2014)
Article
Oncology
Julien Chabanais, Francois Labrousse, Alain Chaunavel, Agnes Germot, Abderrahman Maftah
Article
Biochemistry & Molecular Biology
Audrey Der Vartanian, Julien Chabanais, Claire Carrion, Abderrahman Maftah, Agnes Germot
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Editorial Material
Medicine, General & Internal
Agnes Germot, Abderrahman Maftah
Article
Multidisciplinary Sciences
Asmae Kandoussi, Ismail Boujenane, Clement Auger, Bruno Serranito, Agnes Germot, Mohammed Piro, Abderrahman Maftah, Bouabid Badaoui, Daniel Petit
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnes Germot, Sebastien Legardinier
Article
Agriculture, Dairy & Animal Science
Agnes Germot, Muhammad Gamal Khodary, Othman El-Mahdy Othman, Daniel Petit
Summary: The genetic relationships between several domestic sheep populations in Egypt were analyzed using mtDNA control region sequences. Most breeds seemed to fit with the archeologists' hypothesis, with one breed possibly migrating directly from Turkey. Unexpectedly, one breed from South Egypt showed strong links to thin-tailed desert breeds of Sudan, raising questions about the events leading to this situation.
Article
Biochemistry & Molecular Biology
Florian Pennarubia, Agnes Germot, Emilie Pinault, Abderrahman Maftah, Sebastien Legardinier
Summary: EGF-LDs can be modified by various O-linked sugars, with most mouse proteins experiencing O-fucosylation and/or O-GIcNAcylation. The majority of EGF-LDs undergo only one O-linked sugar modification, while a small percentage undergoes three modifications. The study demonstrated triple O-glycosylation in mouse PAMR1 EGF-LD, indicating complex glycosylation patterns in this protein domain.
Article
Genetics & Heredity
Gloria Gonzalez Curto, Audrey Der Vartanian, Youcef El-Mokhtar Frarma, Line Manceau, Lorenzo Baldi, Selene Prisco, Nabila Elarouci, Frederic Causeret, Daniil Korenkov, Muriel Rigolet, Frederic Aurade, Aurelien De Reynies, Vincent Contremoulins, Frederic Relaix, Orestis Faklaris, James Briscoe, Pascale Gilardi-Hebenstreit, Vanessa Ribes