The Intramembrane Proteases Signal Peptide Peptidase-Like 2a and 2b Have Distinct Functions In Vivo

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b

(2013) Claudia Zahn et al.   FEBS Journal

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

(2012) Hannes Bergmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L

(2011) Lalu Rudyat Telly Savalas et al.   BIOCHEMICAL JOURNAL

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

(2011) Jörg Behnke et al.   FEBS LETTERS

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Molecular characterisation of ‘transmembrane protein 192’ (TMEM192), a novel protein of the lysosomal membrane

(2010) Bernd Schröder et al.   BIOLOGICAL CHEMISTRY

Transmembrane TNF- : structure, function and interaction with anti-TNF agents

(2010) T. Horiuchi et al.   RHEUMATOLOGY

A functional heteromeric MIF receptor formed by CD74 and CXCR4

(2009) Verena Schwartz et al.   FEBS LETTERS

Signal peptide peptidases: A family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins

(2009) Todd E. Golde et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BRI2 as a central protein involved in neurodegeneration

(2008) Maria Tsachaki et al.   Biotechnology Journal

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches

(2008) Anita Sapoznikov et al.   NATURE IMMUNOLOGY

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY