Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells

Protein Kinase C-β Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus

(2012) Corey E. Tabit et al.   CIRCULATION

Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKC  Activation in Diabetes

(2012) A. Mima et al.   DIABETES

Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice

(2011) Kumiko Taguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)

(2011) Yasuhiro Maeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

(2011) Akira Mima et al.   KIDNEY INTERNATIONAL

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

(2010) Christian Rask-Madsen et al.   Cell Metabolism

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells

(2010) Panagiotis D. Venieratos et al.   CELLULAR SIGNALLING

Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

(2009) J. David Symons et al.   CIRCULATION RESEARCH

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mice deficient in PKCβ and apolipoprotein E display decreased atherosclerosis

(2008) Evis Harja et al.   FASEB JOURNAL

Phosphorylation of Ser357of Rat Insulin Receptor Substrate-1 Mediates Adverse Effects of Protein Kinase C-δ on Insulin Action in Skeletal Muscle Cells

(2008) Rizwana Sanaullah Waraich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin through IRS1/Phosphoinositide 3-Kinase/Akt-2 Pathway

(2008) Pedro Geraldes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2

(2008) Stefan Hanke et al.   MOLECULAR & CELLULAR PROTEOMICS

When a domain is not a domain

(2008) Sang Youn Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

(2008) Jinhua Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

(2007) Hadar Sharfi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM