The FBXO4 Tumor Suppressor Functions as a Barrier to BrafV600E-Dependent Metastatic Melanoma

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation

(2011) T. Kanie et al.   MOLECULAR AND CELLULAR BIOLOGY

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

(2011) L. P. Vaites et al.   MOLECULAR AND CELLULAR BIOLOGY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphorylation-dependent regulation of SCFFbx4 dimerization and activity involves a novel component, 14-3-3ɛ

(2011) O Barbash et al.   ONCOGENE

SCF ubiquitin ligases in the maintenance of genome stability

(2011) Joshua S. Silverman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Structural Basis of Selective Ubiquitination of TRF1 by SCFFbx4

(2010) Zhixiong Zeng et al.   DEVELOPMENTAL CELL

Structural Basis of Dimerization-dependent Ubiquitination by the SCFFbx4Ubiquitin Ligase

(2010) Yunfeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

(2010) Blake Ferguson et al.   Pigment Cell & Melanoma Research

C/EBP  targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression

(2010) S. A. Pawar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemical and Molecular Markers in Breast Phyllodes Tumors

(2010) Veselina B. Korcheva et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Main roads to melanoma

(2009) Giuseppe Palmieri et al.   Journal of Translational Medicine

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

(2009) Manas K. Santra et al.   NATURE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

(2009) V K Goel et al.   ONCOGENE

Molecular Pathogenesis of Cutaneous Melanocytic Neoplasms

(2008) Nageatte Ibrahim et al.   Annual Review of Pathology-Mechanisms of Disease

Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer

(2008) Olena Barbash et al.   CANCER CELL

FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias

(2008) Jee Hoon Song et al.   LEUKEMIA RESEARCH