Article
Biochemistry & Molecular Biology
Brandon E. Aubol, Joseph A. Adams
Summary: This article investigates the function of SRPK1 in the nucleus. The study demonstrates that SRPK1 can regulate gene expression during RNA splicing through its interaction with U1-70K. By modulating the interaction between U1-70K, SR proteins, and ESE, SRPK1 affects the alternative splicing of genes.
Article
Oncology
Wei-zhao Peng, Jin Zhao, Xin Liu, Chao-feng Li, Shuang Si, Ren Ma
Summary: The study shows that overexpression of hnRNPA2B1 in GC is associated with poor survival and is required for maintaining a malignant phenotype by promoting cell proliferation, inhibiting cell apoptosis, and increasing cell metastasis. Mechanistically, hnRNPA2B1 is co-expressed with several core spliceosome components and controls alternative splicing of the anti-apoptotic factor BIRC5. The BIRC5 isoform 202 plays an oncogenic role in GC cells, and overexpression of the BIRC5-202 transcript partially restores cisplatin resistance decreased by downregulation of hnRNPA2B1.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Sunkyung Choi, Namjoon Cho, Eun-Mi Kim, Kee K. Kim
Summary: Alternative pre-mRNA splicing plays a critical role in generating multiple mRNA and increasing protein diversity. Specific splicing isoforms have been found to be important in cellular processes, particularly in regulating cell numbers. Abnormal expression of splicing isoforms and factors, as well as disruptions in splicing caused by genetic mutations, are implicated in cancer development and progression. Alternative splicing has potential as a therapeutic target for cancer.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mai Baker, Mayra Petasny, Nadeen Taqatqa, Mercedes Bentata, Gillian Kay, Eden Engal, Yuval Nevo, Ahmad Siam, Sara Dahan, Maayan Salton
Summary: Changes in the cellular environment lead to alterations in chromatin structure, impacting gene expression and alternative splicing. KDM3A, as a chromatin sensor, plays a crucial role in regulating gene expression and splicing factor binding in response to environmental cues.
Article
Oncology
Yao-Jie Pan, Fu-Chun Huo, Meng-Jie Kang, Bo-Wen Liu, Meng-Di Wu, Dong-Sheng Pei
Summary: SRSF11 is found to be overexpressed in colorectal cancer (CRC) and associated with poor prognosis. It plays a pro-metastatic role in both in vitro and in vivo settings. The study highlights the relationship between SRSF11-regulated splicing and CRC metastasis, suggesting a potential therapeutic target and prognostic biomarker in CRC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Zhao-chen Liu, Lu-Hao Li, Ding-Yang Li, Zhi-Qiang Gao, Dong Chen, Bin Song, Bing-Hua Jiang, Xiao-wei Dang
Summary: In this study, multi-omics sequencing data were used to analyze and decipher the molecular functions and underlying mechanisms of KIAA1429 in hepatocellular carcinoma (HCC). The results revealed that KIAA1429 is involved in alternative splicing and regulates genes in cell cycle and apoptosis-associated pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Qi Zhang, Wei Zhang, Jianbo Wei, Zhaoxu Gao, Jianing Guan, Zhibo Cui, Xiaoxue Wang
Summary: This study reveals that the splicing factor SKIP plays a positive regulatory role in ABA signaling in plants. It regulates the splicing of ABA signaling-related genes, affecting the expression of ABA-positive regulators. The study also found that SKIP is involved in the regulation of ABA-mediated genome-wide alternative splicing and differential gene expression.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca M. Sena, Jeffery L. Twiss, Amy S. Gardiner, Michela Dell'Orco, David N. Linsenbardt, Nora Perrone-Bizzozero
Summary: Neuronal Hu/ELAV-like proteins HuB, HuC, and HuD play key roles in the proper development and maintenance of the nervous system by regulating mRNA stability, transport, translation, as well as alternative splicing and polyadenylation. Deletion of HuD has a greater impact on alternative splicing with 310 genes affected, although it also influences polyadenylation of 53 genes. This study provides insights into the transcriptomic effects of HuD deletion on nuclear events in the neocortex.
Article
Biochemistry & Molecular Biology
Li Liu, Dmytro Kryvokhyzha, Catarina Rippe, Aishwarya Jacob, Andrea Borreguero-Munoz, Karin G. Stenkula, Ola Hansson, Christopher W. J. Smith, Steven A. Fisher, Karl Sward
Summary: The study reveals the association between MYOCD and four splicing factors, which are involved in the control of SMC-specific alternative exon usage and splicing. RNA-sequencing and analysis demonstrate that MYOCD contributes to the regulation of transcript diversity through alternative exon usage and splicing, playing a critical role in SMC differentiation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Genetics & Heredity
Ze Liu, Yue Lou, Jia-Chen Cui, Yi Chen, Ji-Ting Liu, Ying Yuan, Yue Han, Yun-Long Huo, Ying-Xin Qi, Zong-Lai Jiang, Qing-Ping Yao
Summary: A novel circRNA, circUVRAG, was identified in the rat vein graft model, showing potential involvement in vein graft disease by regulating VSMC adhesion and migration. Additionally, the splicing factor NOVA1 was found to co-locate with UVRAG pre-mRNA in the nucleus, modulating circUVRAG production. These findings suggest a new potential therapeutic approach for intimal hyperplasia after vein grafts.
Article
Cell Biology
Trishna Pani, Kajal Rajput, Animesh Kar, Harsh Sharma, Rituparna Basak, Nihal Medatwal, Sandhini Saha, Gagan Dev, Sharwan Kumar, Siddhi Gupta, Arnab Mukhopadhyay, Dipankar Malakar, Tushar Kanti Maiti, Aneeshkumar G. Arimbasseri, S. V. S. Deo, Ravi Datta Sharma, Avinash Bajaj, Ujjaini Dasgupta
Summary: The study identified specific alternative splicing events of sphingolipid genes in different subtypes of breast cancer, with an event in CERS2 being a poor prognostic factor for Luminal B subtype, leading to a decrease in very-long-chain ceramides and enhanced cancer cell proliferation and migration. These findings suggest subtype-specific alternative splicing of sphingolipid genes as a potential therapeutic target in breast tumors.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ai Qing Yu, Jie Wang, Shi Tao Jiang, Li Qun Yuan, Hai Yan Ma, Yi Min Hu, Xing Min Han, Li Ming Tan, Zhi Xiao Wang
Summary: Protein posttranslational modification dysregulation can lead to various pathological processes. SIRT7, a NAD(+)-dependent deacetylase, is found to be involved in aging regulation by decrotonylating proteins. The study provides insight into the molecular mechanisms of SIRT7-induced decrotonylation in aging and potential targets for intervention in aging-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Namjeong Choi, Ha Na Jang, Jagyeong Oh, Jiyeon Ha, Hyungbin Park, Xuexiu Zheng, Sunjae Lee, Haihong Shen
Summary: This study investigated the alternative splicing of the Fas gene and identified SRSF6 as a key regulator in this process. The results also showed that the correlation between SRSF6 and Fas expression differs between normal tissues and tumors. This research reveals a novel regulatory mechanism of Fas alternative splicing.
Article
Medicine, Research & Experimental
Lin -Yuan Chen, Xiao-Yu Pang, Can Chen, Hua-Guo Xu
Summary: The transcription factor NF-0B positively regulates the expression of STING via alternative promoter usage, providing a new basis and potential drug targets for the clinical treatment of STING-related diseases.
Article
Cell Biology
Wenrui Qu, Hongjuan Jin, Bing-Peng Chen, Jun Liu, Rui Li, Wenlai Guo, Heng Tian
Summary: The study reveals that CPEB3 is a critical regulator of alternative splicing in neurogenesis, with the ability to partially modulate gene splicing related to neural development, neuron cycle, neurotrophin, synapse, and specific development pathways.