Article
Oncology
Shaniya Ahmad, Madiha Abbas, Mohammad Fahad Ullah, Moammir H. Aziz, Ozal Beylerli, Majid Ali Alam, Mansoor Ali Syed, Shahab Uddin, Aamir Ahmad
Summary: The role of long non-coding RNAs (lncRNAs) in cancer metastasis, particularly in the context of NF-kappa B signaling and epithelial-mesenchymal transition (EMT), is a hot topic of research. NKILA has emerged as a well-studied lncRNA that regulates NF-kappa B and inhibits EMT-induced metastasis. lncRNAs like FOXD2-AS1, KRT19P3, MALAT1, SNHG15, CRNDE, and AC007271.3 are also implicated in the regulation of NF-kappa B signaling and cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Sepideh Mirzaei, Sam Saghari, Farzaneh Bassiri, Rasoul Raesi, Ali Zarrabi, Kiavash Hushmandi, Gautam Sethi, Vinay Tergaonkar
Summary: Metastasis of tumor cells is a significant challenge in cancer patients, and the activation of nuclear factor-kappaB (NF-kappa B) plays a crucial role in regulating the epithelial-to-mesenchymal transition (EMT). The activation of NF-kappa B enhances the invasive properties of tumor cells through inducing EMT mechanism, and this has been confirmed in various cancers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Pharmacology & Pharmacy
Huijie Wu, Shuyi Chen, Chenyang Liu, Jiajia Li, Xiangxiang Wei, Mengping Jia, Jieyu Guo, Jiayu Jin, Dan Meng, Xiuling Zhi
Summary: This study found that the expression of SPTBN1 was significantly lower in primary breast cancer tumors than in normal tissues, and lower levels of SPTBN1 were associated with significantly shorter progression-free survival. Loss of SPTBN1 promoted EMT, the viability of MDA-MB-231 and BT549 in vitro, and the growth of MDA-MB-231 tumor xenografts in vivo by upregulating miR-21 level.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Nannan Lv, Fei Liu, Lan Cheng, Feng Liu, Jinsong Kuang
Summary: TNF-α plays a key role in inducing EMT in papillary thyroid carcinoma (PTC) by affecting the expression of different transcription factors and signal pathways. The activation of different pathways did not show gene differences, with NF-kappa B inhibitors being able to reverse the expression of transcription factors.
Article
Medicine, Research & Experimental
Claudia Winkler, Matthew King, Julie Berthe, Domenico Ferraioli, Anna Garuti, Federica Grillo, Jaime Rodriguez-Canales, Lorenzo Ferrando, Nicolas Chopin, Isabelle Ray-Coquard, Oona Delpuech, Davide Bedognetti, Alberto Ballestrero, Elisabetta Leo, Gabriele Zoppoli
Summary: SLFN11 expression density in HGSOC cancer samples is associated with favorable prognosis and immune activation. Platinum treatments activate immune-related pathways in ovarian cancer cells in an SLFN11-dependent manner, indicative of tumor-immune transactivation.
Article
Biology
Bin Li, Lisi Zheng, Jiayi Ye, Chenmin Zhang, Jie Zhou, Qiaojuan Huang, Yanhua Guo, Luqin Wang, Peng Yu, Shurong Liu, Qiao Lin, Yuxia Luo, Hui Zhou, Jianhua Yang, Lianghu Qu
Summary: This study identifies previously unknown mechanisms of CREB1 in colorectal cancer cell plasticity, including the regulation of lncRNA CCAT1 and NF-kappa B pathways. Knocking out CREB1 triggers epithelial-mesenchymal transition (EMT), inhibits cell proliferation, and enhances cell motility.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Xuelian Cui, Yixuan Wang, Weiqiang Lan, Shuhao Wang, Ying Cui, Xianglan Zhang, Zhenhua Lin, Junjie Piao
Summary: SPOCK1 is upregulated in pancreatic cancer tissues and associated with lymph node metastasis. It promotes pancreatic cancer cell proliferation by affecting cell cycle transition and enhances cell migration and invasion by regulating EMT progression. SPOCK1 also activates the NF-kappa B pathway by interacting with I kappa B alpha, leading to EMT and metastasis in pancreatic cancer.
Article
Cell Biology
Yinuo Li, Shourong Wang, Peng Li, Yingwei Li, Yao Liu, Haiya Fang, Xiyu Zhang, Zhaojian Liu, Beihua Kong
Summary: The study found that upregulation of Rad50 in high-grade serous ovarian cancer was inversely correlated with patient survival, possibly inducing aggressiveness through activation of the NF-kappa B signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Haokun Liu, Ying Zhao, Yanfang Wu, Yutong Yan, Xiaoe Zhao, Qiang Wei, Baohua Ma
Summary: Mastitis is a common and important clinical disease in ruminants, which may lead to inflammatory fibrosis if not promptly treated. This study found that Snail plays a critical role in LPS-induced EMT in GMECs, and the mechanism is dependent on the activation of the TLR4/NF-kappa B signaling pathway.
Article
Oncology
Marcin Michalak, Michel S. Lach, Sylwia Borska, Blazej Nowakowski, Kazuo Umezawa, Wiktoria M. Suchorska
Summary: Ovarian cancer is a lethal gynaecological malignancy with a reduced survival rate due to difficulty in early detection and chemoresistance. Activation of the NF-kappa B signalling pathway is associated with poor prognosis in patients. Developing inhibitors for this pathway has become a target in cancer therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chang-Gun Lee, Soonjae Hwang, Sun-Yeong Gwon, Chanoh Park, Minjeong Jo, Ju-Eun Hong, Ki-Jong Rhee
Summary: Researchers have found that the secretion of BFT by ETBF can induce IL-8 secretion in intestinal epithelial cells by activating the E-cadherin and beta-catenin signaling pathways, leading to acute inflammation.
Article
Oncology
Hao Chen, Xiaobin Chen, Bo Pan, Chutian Zheng, Liangjie Hong, Weili Han
Summary: Keratin 8 (KRT8) is upregulated in lung adenocarcinoma (LUAD) and is associated with prognosis and metastasis. Low KRT8 expression is correlated with better survival rates and clinical characteristics. Downregulation of KRT8 inhibits proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) while inducing apoptosis in lung cancer cells, possibly through the inhibition of NF-κB signaling.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Zhang, Yuhan Chang, Haiyan Xia, Luwei Xu, Xiaowei Wei
Summary: This study demonstrated the potential carcinogenic role of HIST1H2BN in prostate cancer through investigating its effects on cell proliferation, migration, and the EMT phenotype. The study revealed a regulatory axis involving HIST1H2BN, NF-κB, and EMT in the oncogenesis of prostate cancer, suggesting HIST1H2BN as a potential therapeutic target.
Article
Oncology
Kentaro Nakayama, Mohamed Tanjimur Rahman, Munmun Rahman, Kohei Nakamura, Masako Ishikawa, Hiroshi Katagiri, Emi Sato, Tomoka Ishibashi, Kouji Iida, Noriyuki Ishikawa, Satoru Kyo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Oncology
Kentaro Nakayama, Munmun Rahman, Mohammed Tanjimur Rahman, Kohei Nakamura, Emi Sato, Hiroshi Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Sultana Razia, Noriyuki Ishikawa, Satoru Kyo
Article
Pathology
Munmun Rahman, Kentaro Nakayama, Mohammed Tanjimur Rahman, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Kohji Miyazaki
Article
Oncology
Hiroshi Katagiri, Kentaro Nakayama, Mohammed Tanjimur Rahman, Munmun Rahman, Atsuko Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Kohji Miyazaki
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2013)
Article
Biochemistry & Molecular Biology
Munmun Rahman, Kentaro Nakayama, Tomoka Ishibashi, Masako Ishikawa, Mohammed Tanjimur Rahman, Hiroshi Katagiri, Atsuko Katagiri, Kouji Iida, Yoshihiro Kikuchi, Kohji Miyazaki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Oncology
Mohammed Tanjimur Rahman, Kentaro Nakayama, Masako Ishikawa, Munmun Rahman, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Kouji Lida, Kohji Miyazaki
Article
Biochemistry & Molecular Biology
Mohammed T. Rahman, Chaitali Ghosh, Mohammed Hossain, Debra Linfield, Fariba Rezaee, Damir Janigro, Nicola Marchi, Anette H. H. van Boxel-Dezaire
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Alexander Pearlman, Mohammed Tanjimur Rahman, Kinnari Upadhyay, Johnny Loke, Harry Ostrer
Article
Engineering, Biomedical
Sivakumar Vijayaraghavalu, Yue Gao, Mohammed Tanjimur Rahman, Richard Rozic, Nima Sharifi, Ronald J. Midura, Vinod Labhasetwar
Article
Cell Biology
Mohammed Tanjimur Rahman, Santoshi Muppala, Jiahui Wu, Irene Krukovets, Dmitry Solovjev, Dmitriy Verbovetskiy, Chioma Obiako, Edward F. Plow, Olga Stenina-Adognravi
CELL DEATH & DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Mohammed Tanjimur Rahman, Youzhi Kaung, Logan Shannon, Charlie Androjna, Nima Sharifi, Vinod Labhasetwar
Summary: Bone metastasis at an advanced disease stage is common and untreatable. Overexpression of RANKL in tumor-bone marrow microenvironment drives tumor progression and bone resorption. Evaluation of biodegradable nanoparticles localized in tumor tissue showed that the combination treatment with docetaxel and Denosumab completely regressed the tumor, preventing bone resorption without causing mortality.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
M. Rahman, K. Nakayama, M. T. Rahman, M. Ishikawa, H. Katagiri, A. Katagiri, E. Sato, K. Iida, K. Miyazaki
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2016)
Article
Oncology
M. Ishikawa, K. Nakayama, M. T. Rahman, M. Rahman, H. Katagiri, A. Katagiri, T. Ishibashi, K. Iida, N. Nakayama, K. Miyazaki
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2014)
Article
Oncology
Mohammed Tanjimur Rahman, Kentaro Nakayama, Munmun Rahman, Masako Ishikawa, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Emi Sato, Kouji Iida, Noriyuki Ishikawa, Naomi Nakayama, Kohji Miyazaki
ANTICANCER RESEARCH
(2013)
Article
Oncology
Munmun Rahman, Kentaro Nakayama, Mohammed Tanjimur Rahman, Naomi Nakayama, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Yoshiro Otsuki, Satoru Nakayama, Kohji Miyazaki
ANTICANCER RESEARCH
(2013)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)