Article
Biochemistry & Molecular Biology
Chuang Li, Fang Qin, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo, Guihong Sun
Summary: The study revealed that miR-122-5p is selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1, promoting the migration of liver cells. This may contribute to establishing a pre-metastatic micro-environment and hepatic metastasis of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Adam M. Collison, Leon A. Sokulsky, Elizabeth Kepreotes, Ana Pereira de Siqueira, Matthew Morten, Michael R. Edwards, Ross P. Walton, Nathan W. Bartlett, Ming Yang, Thi Hiep Nguyen, Sebastian L. Johnston, Paul S. Foster, Joerg Mattes
Summary: Virus-induced respiratory infections, particularly with rhinoviruses, have significant health impacts on children. Inhibition of miRNA 122 (miR-122) shows promise in reducing inflammation and airway hyperreactivity induced by RV infections, with potential implications for treating bronchiolitis and asthma exacerbations. High miR-122 levels are associated with poorer clinical outcomes, suggesting anti-miR-122 oligonucleotides could be a therapeutic option.
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Biochemistry & Molecular Biology
Vishwa Nath Shukla, Abhishesh Kumar Vikas, Abhishesh Kumar Mehata, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu, Sunil Kumar Mishra
Summary: This study aimed to develop targeted albumin nanoparticles for lung cancer therapy, and showed that folate-conjugated nanoparticles could be more effectively internalized by lung cancer cells and induce apoptosis. The study also confirmed the biocompatibility and lung safety of these nanoparticles. The results demonstrated the potential of targeted albumin nanoparticles for site-specific delivery in lung cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Magdalena Lisiak, Izabela Lewicka, Mariusz Kaczmarek, Jacek Kujawski, Barbara Bednarczyk-Cwynar, Lucjusz Zaprutko, Blazej Rubis
Summary: This study revealed the cytostatic, proautophagic, and anti-migratory activities of pentacyclic triterpenes' derivatives, specifically HIMOXOL and Br-HIMOLID, in HER2-positive breast cancer cells. Both derivatives showed higher cytotoxicity compared to the maternal compound, OA, and were found to decrease cell viability, induce autophagy, and reduce cell migration in the studied breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wanda Baer-Dubowska, Maria Narozna, Violetta Krajka-Kuzniak
Summary: Naturally occurring pentacyclic triterpenoid oleanolic acid (OA) serves as a good scaffold for synthetic derivatives, with the most promising one being 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO). The new group of synthetic triterpenoids, OA oximes, exhibit strong anti-cancer activity and play a significant role in intervening cancer development.
Article
Biochemistry & Molecular Biology
Qian-Fei Xu, Hui-Ping Peng, Xi-Rong Lu, Yun Hu, Zou-Hua Xu, Jin-Kang Xu
Summary: The study found that downregulation of miR-98-5p and upregulation of Treg/Th17-related factors were observed in gastric cancer tissues. Additionally, an imbalance of Treg/Th17 cells was found in the peripheral blood mononuclear cells of gastric cancer patients. Overexpression of miR-98-5p promoted balance of Treg/Th17 cells by targeting IL-6. Oleanolic acid was also shown to promote this balance by upregulating miR-98-5p expression.
Article
Cell Biology
Wei Yan, Minghui Cao, Xianhui Ruan, Li Jiang, Sylvia Lee, Adriana Lemanek, Majid Ghassemian, Donald P. Pizzo, Yuhao Wan, Yueqing Qiao, Andrew R. Chin, Erika Duggan, Dong Wang, John P. Nolan, Jeffrey D. Esko, Simon Schenk, Shizhen Emily Wang
Summary: Breast cancer suppresses O-GlcNAc protein modification in muscle through miR-122, leading to dysregulated skeletal muscle proteolysis with aberrant Ca2+ levels and calpain protease activation.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Shen, Yang Yu, Yuan Yan, Bofan Yu, Wei You
Summary: The long noncoding RNA CASC15 has been found to have prognostic and diagnostic potential for cancer progression and tumorigenesis. This study uncovers the role of CASC15 in regulating the stemness of breast cancer stem cells (BCSCs) and demonstrates its association with metastasis, TNM stage, and survival rates in breast cancer patients. The CASC15/miR-654-5p/MEF2D axis is identified as a key pathway in the regulation of breast cancer stemness and tumor development. These findings hold promise for the development of new therapeutic strategies for breast cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Yuji Shiozaki, Shinobu Miyazaki-Anzai, Audrey L. Keenan, Makoto Miyazaki
Summary: Amino acid deficiency can mimic starvation to induce FAM134B2 expression, with MEF2D and NR4A1 identified as critical transcription factors involved. Integrated signal response and mTOR signals do not contribute to the induction of FAM134B2 under amino acid deficiency.
Article
Biochemistry & Molecular Biology
Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Summary: The role of exogenous miRNAs in renal fibrosis was investigated using a mouse model. miR-122-5p was found to be downregulated in the kidneys of mice with renal fibrosis. Overexpression of miR-122-5p promoted fibrosis, while inhibition of miR-122-5p suppressed fibrosis. miR-122-5p regulated the expression of fibrosis-related mRNAs, including pro-fibrotic TGFBR2 and anti-fibrotic FOXO3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jingyong Xu, Yao Li, Zhe Li, Weiwei Shao, Jinghai Song, Junmin Wei
Summary: This study investigated the molecular mechanisms of the acidic microenvironment in pancreatic cancer (PC) progression. It was found that under acidic conditions, PANC-1 cells exhibited increased proliferation, migration, and invasion. Additionally, the expression of miR-451a, a gene related to mitochondrial oxidative respiration, was reduced in acidic conditions. Overexpression of miR-451a inhibited proliferation, migration, invasion, and stemness of PANC-1 cells under an acidic environment by targeting MEF2D. These findings provide a novel avenue for the future treatment of PC.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhichao Du, Guolong Li, Xiaoyang Zhou, Jian Zhang
Summary: C-3 and C-28 MeON-neoglycosides of oleanolic acid designed and synthesized through neoglycosylation exhibited notable inhibitory effects against human cancer cell lines, with compound 8a showing the most potent antiproliferative activities against HepG2 cells. Further pharmacological experiments revealed that compound 8a could induce morphological changes, cell cycle arrest, and apoptosis in HepG2 cells, suggesting its potential as a rapid strategy for the discovery of antiproliferative agents.
Article
Multidisciplinary Sciences
Fatemeh Dodangeh, Zahra Sadeghi, Parichehr Maleki, Jamshid Raheb
Summary: This study demonstrates that long non-coding RNA SOX2 overlapping transcript (SOX2-OT) plays an oncogenic role in lung cancer by regulating the miR-122-3p/FOXO1 and miR-194-5p/FOXA1 pathways, affecting the biological behaviors of lung cancer cells.
SCIENTIFIC REPORTS
(2023)