Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Review
Oncology
Parnaz Merikhian, Mohammad Reza Eisavand, Leila Farahmand
Summary: Triple-negative breast cancer presents challenges in treatment strategies due to its complexity and heterogeneity, with research showing the pivotal role of Wnt/beta-catenin signaling in resistance development.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Tao Xueqin, Mei Jinhong, Huang Yuping
Summary: INHBA is highly expressed in breast cancer cells and acts as an oncogene by activating the Wnt/beta-catenin pathway, providing a potential therapeutic target for the treatment of breast cancer.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Oncology
Stefan Koch
Summary: This article discusses the control of the Wnt pathway by FOX proteins, and the contribution of their interaction to cancer initiation and progression. Further research on FOX biology may lead to new targeted treatments for cancer.
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Review
Plant Sciences
Laleh Arzi, Homa Mollaei, Reyhane Hoshyar
Summary: This review provides an unprecedented overview of the use of plants and herbal derivatives to inhibit the progression of TNBC by targeting the Wnt/beta-catenin pathway. Herbal medicine extracts and bioactive compounds have been shown to interrupt various steps of Wnt/beta-catenin signaling and inhibit proliferation, metastasis, self-renewal of breast cancer stem cells, and induce apoptosis in TNBC models. These herbal remedies also have the potential to target other overactive pathways in TNBC. Overall, the repression of the Wnt/beta-catenin signaling pathway by herbal derivatives plays an important role in the treatment of TNBC.
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Article
Engineering, Biomedical
Xianquan Feng, Jialiang Zhang, Lina Wu, Wanjing Lin, Zhihong Liu, Xin Zhou, Yang Qi, Zhenzhen Chen, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Qian Zhang, Hongtao Song
Summary: This study evaluates the role of drug self-delivery nanocubes (ATO/PpIX-SMN) combined with anti-PD-L1 in TNBC treatment. The nanocubes enhance photodynamic therapy-induced immunogenic cell death and downregulate tumor signaling. Combined with anti-PD-L1, they promote dendritic cell maturation, increase CTL infiltration, reduce regulatory T cells, and activate the host immune system, effectively treating primary and distal tumors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen, Desheng Lu
Summary: TMEM97 upregulation is associated with poor outcome in multiple human cancers, including breast cancer, by enhancing LRP6-mediated Wnt signaling. TMEM97 interacts with LRP6 to promote CK1 delta/epsilon-dependent phosphorylation of LRP6, leading to stabilization of beta-catenin. In breast cancer cells, TMEM97 deficiency attenuated Wnt/beta-catenin signaling and suppressed tumorigenic properties, suggesting that targeting TMEM97 could be a promising therapeutic strategy for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Oncology
Zhao-Hui Chen, Yao Tian, Guang-Lei Zhou, Hao-Ran Yue, Xue-Jie Zhou, Hai-Yan Ma, Jie Ge, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study found that the promoter region of CMTM7 is hypermethylated in breast cancer tissues and cell lines, indicating the tumor suppressor role of CMTM7 both in vitro and in vivo. Furthermore, CMTM7 interacts with CTNNA1 and regulates Wnt/beta-catenin signaling. Lastly, TCF3 regulates the expression of miR-182-5p. These findings highlight the important role of CMTM7 in breast cancer progression and suggest CMTM7 and other elements in the feedback loop as potential targets for breast cancer therapy.
BREAST CANCER RESEARCH
(2023)
