Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI’s provocative questions

(2015) Mikhail V. Blagosklonny   Oncotarget

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide

(2015) Joanna Triscott et al.   Oncotarget

Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone

(2015) Miklos Jaszberenyi et al.   Oncotarget

Cell death sensitization of leukemia cells by opioid receptor activation

(2015) Claudia Friesen et al.   Oncotarget

Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells

(2015) Mareike Roscher et al.   Oncotarget

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.

(2015) Richard E. Kast et al.   Oncotarget

The Sodium Pump α1 Subunit as a Potential Target to Combat Apoptosis-Resistant Glioblastomas

(2015) Florence Lefranc et al.   NEOPLASIA

Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma

(2015) Sri Hari Krishna Vellanki et al.   NEOPLASIA

Arsenic reverses glioblastoma resistance to mTOR-targeted therapies

(2013) Akio Iwanami et al.   CELL CYCLE

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

(2011) P. A. Insel et al.   Acta Physiologica

Bortezomib Primes Glioblastoma, Including Glioblastoma Stem Cells, for TRAIL by Increasing tBid Stability and Mitochondrial Apoptosis

(2011) T. Unterkircher et al.   CLINICAL CANCER RESEARCH

Induction of apoptosis in pediatric acute lymphoblastic leukemia (ALL) cells by the therapeutic opioid methadone and effective synergy with Bcl-2 inhibition

(2011) Anjali Singh et al.   LEUKEMIA RESEARCH

Recent Advances in Therapy for Glioblastoma

(2010) Jennifer Clarke et al.   ARCHIVES OF NEUROLOGY

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues

(2009) Majid Safa et al.   APOPTOSIS

Activation of cAMP signaling inhibits DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation

(2009) E. H. Naderi et al.   BLOOD

Methadone, Commonly Used as Maintenance Medication for Outpatient Treatment of Opioid Dependence, Kills Leukemia Cells and Overcomes Chemoresistance

(2008) C. Friesen et al.   CANCER RESEARCH

Phosphatidylinositol 3-Kinase Inhibition Broadly Sensitizes Glioblastoma Cells to Death Receptor- and Drug-Induced Apoptosis

(2008) D. Opel et al.   CANCER RESEARCH

Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth

(2008) S. Bao et al.   CANCER RESEARCH

Promoter hypomethylation regulates CD133 expression in human gliomas

(2008) Kouichi Tabu et al.   CELL RESEARCH

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER

Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma

(2008) Chiara Gabellini et al.   JOURNAL OF NEUROCHEMISTRY

DNA-Ligase IV and DNA-Protein Kinase Play a Critical Role in Deficient Caspases Activation in Apoptosis-resistant Cancer Cells by Using Doxorubicin

(2008) Claudia Friesen et al.   MOLECULAR BIOLOGY OF THE CELL

A Systematic Review of Opioid Conversion Ratios Used with Methadone for the Treatment of Pain

(2008) Douglas J. Weschules et al.   PAIN MEDICINE