Article
Food Science & Technology
Samuel Mendoza-Perez, Rolando Salvador Garcia-Gomez, Maria-del-Carmen Duran-Dominguez-de-Bazua
Summary: This study examined the effects of chronic sweetener consumption on liver enzyme activity, hormones, and biochemical parameters. The findings showed that consumption of nutritive sweeteners and saccharin resulted in higher glycolytic and lipogenic enzyme activity levels.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Ma Josefina Ruiz de Azua, Alvaro Cruz-Carrion, Begona Muguerza, Anna Arola-Arnal, Manuel Suarez
Summary: This study evaluated the effects of sweet cherry from different sources on the metabolism and gene expression in rats under simulated different seasons. Results showed that both the photoperiod and treatments significantly impacted blood parameters and hepatic enzyme gene expression.
Article
Cell Biology
Wei Wang, Yulin Kong, Xia Wang, Zhe Wang, Chunlei Tang, Jinyou Li, Qin Yang, Yong Q. Chen, Shenglong Zhu
Summary: This study identified a novel SCD1 inhibitor, E6446, through high-throughput virtual screening. It was found that E6446 significantly inhibited adipogenic differentiation and hepatic lipogenesis via SCD1-ATF3 signaling. Additionally, E6446 showed strong interaction with SCD1 and had beneficial effects on hepatic steatosis, hepatic lipid droplet accumulation, and insulin resistance in high-fat diet-fed mice.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Endocrinology & Metabolism
Ruiyi Zhu, Shuchun Chen
Summary: This study investigated the effect of semaglutide on lipid metabolism in obese mice. The results showed that semaglutide can effectively reduce visceral fat and blood lipids and improve glucose metabolism in obese mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaoyue Song, Shiying Liu, Jianan Wang, Jiamin Chai, Jigang Wen, Chengli Xu
Summary: People living in plains tend to decrease in body weight or body fat percentage after entering the plateau. Previous studies have found that plateau animals can burn fat and release calories through white adipose tissues (WATs) browning. However, these studies have focused on the effect of cold stimulation that induced WATs browning while there's hardly study on the effect of hypoxia. In this study, we investigate the effect of hypoxia on WATs browning in rats from acute to chronic hypoxia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Article
Cell Biology
Joana Fisch, Ana Carolina de Moura, Vanessa Feistauer, Luiza Steffens Reinhardt, Patricia Molz, Ana Moira Moras, Dinara Jaqueline Moura, Priscila Oliveira de Souza, Elizandra Braganhol, Silvana Almeida, Renata Padilha Guedes, Alethea Gatto Barschak, Marcia Giovenardi
Summary: This study investigated the effects of different maternal diets during pregnancy and lactation on adipose tissue inflammation and liver tissue oxidative stress in both mothers and their female offspring. The results showed that a hypercaloric diet led to non-alcoholic steatohepatitis (NASH) and increased inflammation in mothers. A restricted diet caused increased inflammation in the offspring. In conclusion, maternal diet during pregnancy and lactation affects the liver and adipose tissues in both mothers and their offspring.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. These adaptations are driven by a lipogenic subpopulation of brown adipocytes located around Ucp1hi adipocytes, and are associated with the production of acylcarnitines.
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. This response is driven by a lipogenic subpopulation of brown adipocytes, which produce acylcarnitines to enhance the thermogenic response.
Article
Nutrition & Dietetics
Andrew O. Odegaard, David R. Jacobs, Lisa B. Van Wagner, Mark A. Pereira
Summary: This study found a monotonic increase in levels of visceral adipose tissue, liver fat, and odds of having metabolic-associated fatty liver disease in middle age according to higher average fast-food intake over the preceding 25 years.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Yamasaki, Shinya Hasegawa, Shotaro Ozaki, Masahiko Imai, Daisuke Saito, Noriko Takahashi
Summary: This study investigates the effects of diet-induced obesity on acetoacetyl-CoA synthetase (AACS) in brown adipose tissue (BAT). The results show that a high-fat diet suppresses AACS expression in BAT, leading to a decrease in lipid synthesis. The findings suggest that AACS-mediated ketone body utilization pathway plays a crucial role in regulating lipogenesis in BAT.
Article
Cell Biology
Lorna Mulvey, Stephen E. Wilkie, Gillian Borland, Kate Griffiths, Amy Sinclair, Dagmara McGuinness, David G. Watson, Colin Selman
Summary: Genetic background plays a role in how organisms respond to interventions like caloric restriction, impacting parameters such as body weight, adipose tissue mass, glucose tolerance, and insulin levels. Metabolomic analysis revealed specific metabolic differences between different mouse strains under the same caloric restriction, highlighting the importance of how fat depots dynamically respond to caloric restriction in influencing lifespan.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yusuke Igarashi, Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Miyoko Yamaoka, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that both the quantity and density of visceral adipose tissue (VAT) were associated with the prevalence and incidence of nonalcoholic fatty liver disease (NAFLD). Visceral fat density (VFD) may be more related to the incidence of NAFLD than visceral fat area (VFA) index.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cell Biology
Patricia Corrales, Marina Martin-Taboada, Yurena Vivas-Garcia, Lucia Torres, Laura Ramirez-Jimenez, Yamila Lopez, Daniel Horrillo, Rocio Vila-Bedmar, Eloisa Barber-Cano, Adriana Izquierdo-Lahuerta, Maria Pena-Chilet, Carmen Martinez, Joaquin Dopazo, Manuel Ros, Gema Medina-Gomez
Summary: Caloric restriction is a non-pharmacological intervention that improves metabolic defects associated with aging. MiRNA expression levels can serve as predictive tools for aging-related alterations. Specific miRNAs contribute to impaired insulin-stimulated glucose metabolism in subcutaneous white adipose tissue, and their expression is modified by caloric restriction, suggesting their potential as biomarkers for age-related metabolic alterations.
Article
Genetics & Heredity
Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski, Julian Swierczynski
GENES AND NUTRITION
(2016)
Article
Genetics & Heredity
Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski, Julian Swierczynski
GENES AND NUTRITION
(2016)
Review
Cardiac & Cardiovascular Systems
Ryszard T. Smolenski, Iwona Rybakowska, Jacek Turyn, Pawel Romaszko, Magdalena Zabielska, Anne Taegtmeyer, Ewa M. Slominska, Krystian K. Kaletha, Paul J. R. Barton
CARDIOVASCULAR DRUGS AND THERAPY
(2014)
Article
Endocrinology & Metabolism
Elzbieta Sucajtys-Szulc, Jacek Turyn, Elzbieta Goyke, Justyna Korczynska, Ewa Stelmanska, Ewa Slominska, Ryszard T. Smolenski, Boleslaw Rutkowski, Julian Swierczynski
Article
Biochemistry & Molecular Biology
Iwona Rybakowska, Pawel Romaszko, Magdalena Zabielska, Jacek Turyn, Krystian Kaletha, Paul J. Barton, Ewa M. Slominska, Ryszard T. Smolenski
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2014)
Article
Endocrinology & Metabolism
Ewa Stelmanska, Tomasz Sledzinski, Jacek Turyn, Malgorzata Presler, Justyna Korczynska, Julian Swierczynski
REGULATORY PEPTIDES
(2013)
Article
Biology
Tomasz Sledzinski, Jacek Turyn, Ewa Stelmanska, Malgorzata Presler, Jerzy Klimek, Julian Swierczynski
CENTRAL EUROPEAN JOURNAL OF BIOLOGY
(2011)
Article
Biology
Jacek Turyn, Adriana Mika, Piotr Stepnowski, Julian Swierczynski
CENTRAL EUROPEAN JOURNAL OF BIOLOGY
(2012)
Review
Biochemistry & Molecular Biology
Aleksandra Czumaj, Sylwia Szrok-Jurga, Areta Hebanowska, Jacek Turyn, Julian Swierczynski, Tomasz Sledzinski, Ewa Stelmanska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Jacek Siewiera, Michal Smolenski, Natalia Jermakow, Jacek Kot, Klaudia Brodaczewska, Jacek Turyn, Magdalena A. Zabielska-Kaczorowska, Nils Ludwig, Miroslaw J. Szczepanski
Summary: While differences were observed in ADMA, arginine derivatives, and cytokine concentrations among patient groups, HBOT did not have any significant effect on these parameters, suggesting its neutral impact on inflammation and endothelial injury.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Zuzanna Gogulska, Zaneta Smolenska, Jacek Turyn, Adriana Mika, Zbigniew Zdrojewski
Summary: This review summarized studies on lipidomics in systemic sclerosis, focusing on lipoproteins, fatty acids, cholesterol, and other components, highlighting their potential role in the disease pathology.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
M. A. Zabielska, J. Turyn, B. Kutryb-Zajac, E. M. Slominska, R. T. Smolenski
PURINERGIC SIGNALLING
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
M. A. Zabielska, J. Turyn, B. Kutryb-Zajac, E. M. Slominska, R. T. Smolenski
PURINERGIC SIGNALLING
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
M. A. Zabielska, P. Mierzejewska, J. Turyn, J. Kwiatkowska, A. Wojtczyk-Miaskowska, E. M. Slominska, Z. Kmiec, R. T. Smolenski
PURINERGIC SIGNALLING
(2018)