Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Review
Pharmacology & Pharmacy
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy, Rina Rosin-Arbesfeld
Summary: The Wnt pathway plays a crucial role in regulating embryogenic developmental processes and tissue homeostasis via beta-catenin. Dysregulation of this pathway has been implicated in carcinogenesis, particularly in colorectal cancer. While the Wnt cascade is an attractive target for therapeutic intervention against CRC, its complexity and challenges need to be addressed for effective treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Oncology
Kuang He, Wen-Juan Gan
Summary: The Wnt/beta-catenin signaling pathway is closely associated with the carcinogenesis and progression of colorectal cancer (CRC), playing a crucial role in cancer-related processes. Hyperactivation of the pathway is observed in almost all CRC cases and contributes to cancer stem cell propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss the involvement of the Wnt/beta-catenin signaling pathway in CRC and potential therapeutic approaches.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Cell Biology
Domenico Conza, Paola Mirra, Francesca Fiory, Luigi Insabato, Antonella Nicolo, Francesco Beguinot, Luca Ulianich
Summary: Metformin is a widely used drug for type 2 diabetes mellitus therapy, which not only lowers blood glucose levels but also improves various disease states and has anti-tumoral effects. Its anti-tumoral effects are mainly mediated by activating AMPK, but other signaling pathways are also involved.
Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yan Zhuang, Chunlan Ning, Pengfei Liu, Yanpeng Zhao, Yue LI, Zhenchi Ma, Luling Shan, Yingzhe Piao, Peng Zhao, Xun Jin
Summary: LSM12, highly expressed in colorectal cancer tissues, is involved in regulating CRC progression by impacting the protein stability of CTNNB1 and activating the downstream WNT signaling pathway. Depletion of LSM12 inhibits cancer cell growth and promotes cancer cell apoptosis, leading to reduced tumor growth in vivo.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Oncology
Wulin Shan, Chunyang Dai, Huanhuan Zhang, Dan Han, Qiyi Yi, Bairong Xia
Summary: This study found that downregulation of ACY1 could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating the Wnt/β-catenin signaling pathway. These findings suggest that ACY1 may serve as a potential radiotherapy target for cetuximab-resistant CRC.
Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.
Article
Chemistry, Multidisciplinary
Qihao Pan, Fenghai Yu, Huilin Jin, Peng Zhang, Xiaoling Huang, Jingxuan Peng, Xiaoshan Xie, Xiangli Li, Ning Ma, Yue Wei, Weijie Wen, Jieping Zhang, Boyu Zhang, Hongyan Yu, Yuanxun Xiao, Ran-yi Liu, Qingxin Liu, Xiangqi Meng, Mong-Hong Lee
Summary: This study has uncovered the role of eIF3f in regulating colorectal cancer (CRC) through its impact on phosphoglycerate dehydrogenase (PHGDH) and the Serine-Glycine-One-Carbon (SGOC) signaling pathway. The upregulation of eIF3f in CRC tumor tissues is shown to be mediated by both Wnt and EGF signaling pathways. Mechanistically, eIF3f antagonizes PHGDH ubiquitination mediated by FBXW7β through its deubiquitinating activity, and it also increases MYC-mediated PHGDH transcription by its deubiquitinating activity. This study provides new insights into targeting the eIF3f-PHGDH axis in CRC.
Article
Oncology
Shenglan Liu, Junhong Wu, Xiaolu Lu, Caiyao Guo, Qisheng Zheng, Yu Wang, Qiao Hu, Shuigen Bian, Li Luo, Qilai Cheng, Zhiping Liu, Wei Dai
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality and has limited effective druggable targets. Targeting cancer stem cells (CSCs) may provide a promising strategy against CRC. Cyclin-dependent kinase 12 (CDK12) is involved in the self-renewal of CSCs and may serve as a potential therapeutic target. In this study, CDK12 was found to be required for CRC survival, and its activation promoted tumor initiation, outgrowth, metastasis, and self-renewal of CRC CSCs through Wnt/beta-catenin signaling. The study suggests that CDK12 is a potential druggable target for CRC treatment.
EXPERIMENTAL CELL RESEARCH
(2023)