Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Phosphoproteomics of vasopressin signaling in the kidney

(2011) Jason D Hoffert et al.   Expert Review of Proteomics

Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes

(2011) Marina Pajic et al.   HUMAN GENETICS

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

(2011) Peter P. Ruvolo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Enhanced invasiveness in multidrug resistant leukemic cells is associated with overexpression of P-glycoprotein and cellular inhibitor of apoptosis protein

(2011) Meng Hu et al.   LEUKEMIA & LYMPHOMA

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

(2011) Markus K Muellner et al.   Nature Chemical Biology

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms

(2011) Pixu Liu et al.   NATURE MEDICINE

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)

(2010) J. R. Dry et al.   CANCER RESEARCH

Use of molecular markers for predicting therapy response in cancer patients

(2010) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

A Self-validating Quantitative Mass Spectrometry Method for Assessing the Accuracy of High-content Phosphoproteomic Experiments

(2010) Pedro Casado et al.   MOLECULAR & CELLULAR PROTEOMICS

Confident Phosphorylation Site Localization Using the Mascot Delta Score

(2010) Mikhail M. Savitski et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

(2010) B. Bodenmiller et al.   Science Signaling

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

Quantitative Phosphoproteomics of Tomato Mounting a Hypersensitive Response Reveals a Swift Suppression of Photosynthetic Activity and a Differential Role for Hsp90 Isoforms

(2009) Iris J. E. Stulemeijer et al.   JOURNAL OF PROTEOME RESEARCH

A New Approach for Quantitative Phosphoproteomic Dissection of Signaling Pathways Applied to T Cell Receptor Activation

(2009) Vinh Nguyen et al.   MOLECULAR & CELLULAR PROTEOMICS

Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

(2009) Kazuishi Kubota et al.   NATURE BIOTECHNOLOGY

Shifting paradigms: the seeds of oncogene addiction

(2009) Charles L Sawyers   NATURE MEDICINE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

(2009) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Analytical strategies for phosphoproteomics

(2009) Tine E. Thingholm et al.   PROTEOMICS

Challenges and Opportunities in Defining the Essential Cancer Kinome

(2009) B. D. Manning   Science Signaling

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

Targeted therapies in breast cancer: Where are we now?

(2008) Serena Di Cosimo et al.   EUROPEAN JOURNAL OF CANCER

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines

(2008) D. A. Grueneberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinase requirements in human cells: I. Comparing kinase requirements across various cell types

(2008) D. A. Grueneberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Proliferation Gene Discovery Through Functional Genomics

(2008) M. R. Schlabach et al.   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Deregulation of Signaling Pathways in Acute Myeloid Leukemia

(2008) Claudia Scholl et al.   SEMINARS IN ONCOLOGY