Article
Medicine, Research & Experimental
Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu-Wai-Man, Pascal Reynier, Timothy Wai
Summary: Mutations in OPA1 can cause DOA or DOA+ with severe neurological deficits, while depletion of PGS1 may help restore mitochondrial morphology and improve defects.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhenzhen Wang, Jiangjiexing Wu, Jia-Jia Zheng, Xiaomei Shen, Liang Yan, Hui Wei, Xingfa Gao, Yuliang Zhao
Summary: The study uses density functional theory calculations to investigate the principles behind the SOD-like catalytic activity of nanomaterials, proposing energy level and adsorption energy principles for quantitatively describing the activity. These principles were validated through experiments on metal-organic frameworks and can be easily implemented in computer programs for screening NMs with intrinsic SOD-like activity. A general predicting theory for superoxide-dismutase mimicking nanomaterials is currently lacking.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Ilker Tezsevin, Mauritius C. M. van de Sanden, Suleyman Er
Summary: This study performed density functional theory calculations to generate oxygen vacancy formation energy data for a range of cubic perovskite materials, and calculated area-specific resistance data related to oxygen reduction reaction and oxygen ion conductivity. By screening 31 candidate perovskites, the study identified materials with properties between state-of-the-art SOFC cathode and oxygen permeation components. The research also presented an intuitive approach to estimate complex perovskite data by using simple perovskite data, aiming to boost future explorations in diverse energy applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Srishyam Raghavan, Brian P. Chaplin, Shafigh Mehraeen
Summary: Predicting the adsorption energies of small molecules on electrocatalysts is important for accelerating design and screening. Descriptors based on geometric and electronic properties have limitations in predicting adsorption energies on different substrates. Machine learning algorithms CGCNN and ALIGNN outperform these descriptors in adsorption energy predictions.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Multidisciplinary
Mingkai Tang, Liyufen Dai, Mingqiang Cheng, Yuan Zhang, Yanghe Wang, Xiangli Zhong, Jinbin Wang, Feng An, Ming Ma, Mingqiang Huang, Changjian Li, Jiangyu Li, Gaokuo Zhong
Summary: This article proposes a synthesis strategy based on high-throughput pulsed laser deposition technology to precisely control the thickness of oxide thin films. With this method, STO thin films with different thicknesses were successfully synthesized, and a transition from unipolar to bipolar resistive switching mode was observed as the film thickness increased. The STO thin film with a thickness of 20.3 nm exhibited excellent conductance modulation properties under the application of electrical pulses as well as significant reliability for emulating various synaptic functions, making it a promising material for artificial neuromorphic computing applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Paula Tena-Morraja, Guillem Rique-Pujol, Claudia Muller-Sanchez, Manuel Reina, Ofelia M. Martinez-Estrada, Francesc X. Soriano
Summary: Synaptic activity in the central nervous system consumes the most energy. New research reveals that an episode of synaptic activity increases mitochondrial bioenergetics by inducing the expression of iron metabolism genes, resulting in enhanced cellular and mitochondrial iron uptake. The study suggests a coordinated expression of synaptic plasticity programs and energy demands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Byung Chul Yeo, Hyunji Nam, Hyobin Nam, Min-Cheol Kim, Hong Woo Lee, Sung-Chul Kim, Sung Ok Won, Donghun Kim, Kwan-Young Lee, Seung Yong Lee, Sang Soo Han
Summary: The study introduces a high-throughput screening protocol for discovering alternative catalysts to palladium, identifying a previously unreported bimetallic catalyst with enhanced performance and productivity.
NPJ COMPUTATIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Carla Lopes, I. Luisa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, Jose Sereno, Joao Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mario N. Laco, Cristina Januario, Miguel Castelo Branco, A. Cristina Rego
Summary: Deficits in mitochondrial function and redox deregulation occur in early stages of Huntington's disease and can progress with disease manifestation.
Review
Developmental Biology
Zoe C. Johnston, Franz S. Gruber, Sean G. Brown, Neil R. Norcross, Jason Swedlow, Ian H. Gilbert, Christopher L. R. Barratt
Summary: Despite recent advances, there is still incomplete understanding of male infertility and male non-hormonal contraceptives. Direct observation of compounds' effects on sperm function can increase knowledge and advance the field.
Article
Chemistry, Multidisciplinary
Matz Liebel, Irene Calderon, Nicolas Pazos-Perez, Niek F. van Hulst, Ramon A. Alvarez-Puebla
Summary: Large-scale SERS particle screening (LSSPS) is a fast multiplexed widefield screening approach that quantifies both Raman and Rayleigh scattering simultaneously, allowing for direct quantification of the fraction of SERS-active particles and unprecedented correlation of SERS activity with particle size.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Frederic Bouillaud
Summary: This article examines the consequences of sulfide oxidation by mitochondrial sulfide quinone reductase in mammalian cells. The oxidation of sulfide helps to avoid self-poisoning and has a lower ATP/O-2 ratio compared to other mitochondrial substrates. It increases cellular oxygen consumption and impacts the cellular ATP/ADP ratio.
Article
Chemistry, Physical
Yiran Wang, Riming Hu, Yongcheng Li, Fuhe Wang, Jiaxiang Shang, Jianglan Shui
Summary: By utilizing density functional theory (DFT), this study investigated the oxygen reduction reaction (ORR) catalytic properties of 180 types of single-atom catalysts (SACs) and found that the adsorption free energy of OH* serves as a universal descriptor for predicting ORR catalytic activity accurately. The research revealed that phthalocyanine, N-coordination graphene, and metal-organic frameworks exhibit relatively lower overpotentials, making them promising supports for single metal atom. Additionally, Co-doped metal-organic frameworks, Ir-doped phthalocyanine, Co-doped N-coordination graphene, Co-doped graphdiyne, and Rh-doped phthalocyanine show extremely low overpotentials comparable to Pt (111). This study provides valuable guidance for the design and selection of carbon-supported SACs for the oxygen reduction reaction.
Article
Chemistry, Physical
Teng Zhang, Yutong Wu, Yihong Yu, Yijie Li, Gaowu Qin, Song Li
Summary: A high-throughput experimental scheme is used to search for effective OER oxide electrocatalysts, and a material library of Mn-Co-Fe-Ni oxide is rapidly prepared and screened for OER activity. The composition of Mn5Co10Fe30Ni55Ox exhibits the highest catalytic activity, and a nanowire catalyst of the corresponding composition achieves low overpotential and a Tafel slope.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chao Lin, Xiang Feng, Dominik Legut, Xiaopeng Liu, Zhi Wei Seh, Ruifeng Zhang, Qianfan Zhang
Summary: This study presents an automated high-throughput workflow for screening high-efficiency photocatalytic OER catalysts. Through thermodynamic and photophysical property investigations, specific materials like β-ZrSi2N4 and β-HfSi2N4 are identified as efficient catalysts.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Cell Biology
Prashanth Gowda, P. Hemachandra Reddy, Subodh Kumar
Summary: Alzheimer's disease is the most common cause of dementia, with a focus on mitochondrial dysfunction in neurons. Research is centered around mitochondrial miRNAs and their regulatory roles in mitochondrial and synaptic functions. However, more research is needed to confirm the specific locations and roles of individual mitochondrial miRNAs in the development of AD.
AGEING RESEARCH REVIEWS
(2022)