Review
Neurosciences
Anastasiia Kotliarova, Yulia A. Sidorova
Summary: This article summarizes the effects of GDNF family ligands on neuropathic pain and neuroinflammation, as well as the potential therapeutic implications of targeting GFL receptors in neurodegenerative disorders and neuropathic pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell & Tissue Engineering
Kristijan Pazur, Ioannis Giannios, Mathias Lesche, Eva Rodriguez-Aznar, Anthony Gavalas
Summary: Hoxb1 plays different roles in neuromesodermal progenitors and hindbrain neural progenitors, promoting survival and specifying neural cell differentiation through regulation of Fgf signaling and synergistic interaction with shh. This highlights the potential of Hox genes in guiding cell specification and transplantation for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Sarah E. Adams, Andrew G. Purkiss, Phillip P. Knowles, Andrea Nans, David C. Briggs, Annabel Borg, Christopher P. Earl, Kerry M. Goodman, Agata Nawrotek, Aaron J. Borg, Pauline B. McIntosh, Francesca M. Houghton, Svend Kjaer, Neil Q. McDonald
Summary: The study reports the structure of zebrafish RET, revealing its flexibility and conformational changes in ligand-co-receptor recognition. The results show that RET has a flexible and rigid arm to adapt to different co-receptors and recognize GFL dimers.
Article
Medicine, General & Internal
Linping Gu, Wenxiang Ji, Yunhua Xu, Yuchen Han, Hong Jian
Summary: This case report presents the efficacy of pralsetinib in a NSCLC patient with 3 concurrent RET fusions. The patient achieved partial response with gradually reduced dosages of pralsetinib, demonstrating sensitivity of the newly identified RET fusions to this selective inhibitor and suggesting low-dose treatment option for patients with renal insufficiency.
Article
Oncology
Yan Meng, Yilin Yang, Yujia Fang, Xinqing Lin, Xiaohong Xie, Haiyi Deng, Jianhui Wu, Maolin Zhou, Ni Sun, Zhanhong Xie, Ming Liu, Ming Ouyang, Yinyin Qin, Chunxia Su, Chengzhi Zhou
Summary: Rearranged during transfection (REf) fusion is a rare mutation in non-small cell lung cancer (NSCLC) in China. A retrospective analysis found that RET-TKI had better response rate and progression-free survival compared to other regimens. Chemotherapy is also a good option for this group of patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Pietro Locantore, Roberto Novizio, Andrea Corsello, Rosa Maria Paragliola, Alfredo Pontecorvi, Salvatore Maria Corsello
Summary: Pralsetinib, a highly selective RET inhibitor, has shown higher potency and lower toxicity compared to traditional MKIs in the treatment of RET-mutated thyroid cancer. Clinical validation studies have demonstrated a better overall response rate with pralsetinib, pointing towards its potential as a promising treatment option for patients with this specific mutation. Future clinical trials and data analysis are warranted to further understand the full pharmacological profile and clinical benefits of pralsetinib.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Review
Endocrinology & Metabolism
Antonio Matrone, Carla Gambale, Alessandro Prete, Rossella Elisei
Summary: Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from parafollicular C-cells. Surgical treatments, multikinase inhibitors, highly selective RET inhibitors, and radionuclide therapy are discussed as systemic treatments for advanced and metastatic MTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Rossella Elisei, Enrique Grande, Michael C. Kreissl, Sophie Leboulleux, Tarun Puri, Nicolas Fasnacht, Jaume Capdevila
Summary: The incidence of thyroid cancer is increasing globally, with Europe ranking second in disease burden after Asia. Over the past few decades, research has identified key molecular pathways and targetable kinases/drivers for each histologic subtype of thyroid cancer. Newer and selective RET inhibitors, such as selpercatinib and pralsetinib, have shown promising efficacy and favorable toxicity profiles in clinical trials for the treatment of RET-driven advanced thyroid cancer. Genetic testing is crucial to identify RET alterations and determine the optimal treatment approach.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qian Liu, Lijuan Hua, Chen Bao, Luxia Kong, Jiannan Hu, Chao Liu, Ziling Li, Shuyun Xu, Xiansheng Liu
Summary: The Syk inhibitor R406 improves sensitivity to dexamethasone by modulating GR, providing a reference for the development of drugs to treat severe steroid-resistant asthma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Livia La Barbera, Francescangelo Vedele, Annalisa Nobili, Paraskevi Krashia, Elena Spoleti, Emanuele Claudio Latagliata, Debora Cutuli, Emma Cauzzi, Ramona Marino, Maria Teresa Viscomi, Laura Petrosini, Stefano Puglisi-Allegra, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Fiorenzo Conti, Marcello D'Amelio
Summary: Recent studies suggest that degeneration of dopaminergic neurons in the Ventral Tegmental Area could be one of the first events in Alzheimer's Disease. Using a mouse model, researchers found that treatment with Nilotinib could reduce phosphorylation of c-Abl, improve autophagy, lower A beta levels, and prevent degeneration of dopaminergic neurons in the VTA. The drug also preserved dopamine outflow to the hippocampus and improved hippocampal-related cognitive functions.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Quinton Blount, Ignacio Hernandez-Morato, Yalda Moayedi, Michael J. Pitman
Summary: This study investigates the differences in GDNFR expression between embryogenesis and after RLN injury, and provides insights into therapeutic targets for regeneration after RLN injury.
Article
Biochemistry & Molecular Biology
Asmin Tulpule, Juan Guan, Dana S. Neel, Hannah R. Allegakoen, Yone Phar Lin, David Brown, Yu-Ting Chou, Ann Heslin, Nilanjana Chatterjee, Shriya Perati, Shruti Menon, Tan A. Nguyen, Jayanta Debnath, Alejandro D. Ramirez, Xiaoyu Shi, Bin Yang, Siyu Feng, Suraj Makhija, Bo Huang, Trever G. Bivona
Summary: A membraneless, protein granule-based subcellular structure has been identified to organize RTK/RAS/MAPK signaling in cancer cells, actively signaling within the cytoplasm and activating RAS independently of lipid membranes. The formation of RTK protein granules is critical for oncogenic RAS/MAPK signaling output in these cells. This study reveals a distinct subcellular platform for organizing oncogenic RTK and RAS signaling through higher-order cytoplasmic protein assembly.
Article
Biochemistry & Molecular Biology
Wenli Liu, Hongzhen Li, Wulin Aerbajinai, Istvan Botos, Griffin P. Rodgers
Summary: Small intestine adenocarcinoma is a rare malignancy with distinct characteristics, and a fusion of OLFM4 and RET has been identified in patients; OLFM4-RET fusion induces cellular transformation and activates signaling pathways promoting tumorigenesis; Targeted expression of OLFM4-RET in the small intestine leads to hyperplasia, adenoma, or adenocarcinoma in transgenic mice.
Article
Food Science & Technology
Mei-ling Fan, Kun Wei, Xiao-meng Wei, Jun-jie Zhang, Jin-gang Hou, Qiong Shen, Yin-shi Sun, Xin-dian Li, Zi Wang, Li-li Jiao, Wei Li
Summary: This study revealed the inhibitory effect of Platycodin D (PD) on intestinal cell apoptosis mediated by ER stress. PD exerted an intestinal protective effect through the inhibition of ER stress in CP-treated mice and IEC-6 cells.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Antonio Passaro, Giuseppe Lo Russo, Francesco Passiglia, Manolo D'Arcangelo, Andrea Sbrana, Marco Russano, Laura Bonanno, Raffaele Giusti, Giulio Metro, Federica Bertolini, Salvatore Grisanti, Annamaria Carta, Fabiana Cecere, Michele Montrone, Giacomo Massa, Fabiana Perrone, Francesca Simionato, Giorgia Guaitoli, Vieri Scotti, Carlo Genova, Antonio Lugini, Lucia Bonomi, Ilaria Attili, Filippo de Marinis
Summary: In the real-world setting, pralsetinib demonstrated durable systemic activity and intracranial response in patients with RET-fusion positive NSCLC. The toxicity profile of pralsetinib was consistent with previous reports.
Article
Neurosciences
Chaoling Dong, Kelsey M. Greathouse, Rebecca L. Beacham, Steven P. Palladino, E. Scott Helton, Eroboghene E. Ubogu
EXPERIMENTAL NEUROLOGY
(2017)
Article
Peripheral Vascular Disease
E. Scott Helton, Steven Palladino, Eroboghene E. Ubogu
MICROVASCULAR RESEARCH
(2017)
Review
Biotechnology & Applied Microbiology
Shuang Liu, Chaoling Dong, Eroboghene Ekamereno Ubogu
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2018)
Article
Multidisciplinary Sciences
Steven P. Palladino, E. Scott Helton, Preti Jain, Chaoling Dong, Michael R. Crowley, David K. Crossman, Eroboghene E. Ubogu
SCIENTIFIC REPORTS
(2017)
Article
Clinical Neurology
Orell Mielke, Vera Bril, David R. Cornblath, John-Philip Lawo, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Ingemar S. J. Merkies, Gen Sobue, Billie Durn, Amgad Shebl, Ivo N. van Schaik, A. Sabet, K. George, L. Roberts, R. Carne, S. Blum, R. Henderson, P. Van Damme, J. Demeestere, S. Larue, C. D'Amour, P. Kunc, M. Valis, J. Sussova, T. Kalous, R. Talab, M. Bednar, T. Toomsoo, I. Rubanovits, K. Gross-Paju, U. Sorro, M. Saarela, M. Auranen, J. Pouget, S. Attarian, G. Le Masson, A. Wielanek-Bachelet, C. Desnuelle, E. Delmont, P. Clavelou, D. Aufauvre, J. Schmidt, J. Zschuentzsch, C. Sommer, D. Kramer, O. Hoffmann, C. Goerlitz, J. Haas, M. Chatzopoulos, R. Yoon, R. Gold, P. Berlit, A. Jaspert-Grehl, D. Liebetanz, A. Kutschenko, M. Stangel, C. Trebst, P. Baum, F. Bergh, J. Klehmet, A. Meisel, F. Klostermann, J. Oechtering, H. Lehmann, M. Schroeter, T. Hagenacker, D. Mueller, A. Sperfeld, F. Bethke, V. Drory, A. Algom, D. Yarnitsky, B. Murinson, A. Di Muzio, F. Ciccocioppo, S. Sorbi, S. Mata, A. Schenone, M. Grandis, G. Lauria, D. Cazzato, G. Antonini, S. Morino, D. Cocito, M. Zibetti, T. Yokota, T. Ohkubo, T. Kanda, M. Kawai, K. Kaida, H. Onoue, S. Kuwabara, M. Mori, M. Iijima, K. Ohyama, M. Baba, M. Tomiyama, K. Nishiyama, T. Akutsu, K. Yokoyama, K. Kanai, I. N. van Schaik, F. Eftimov, N. C. Notermans, N. Visser, C. Faber, J. Hoeijmakers, K. Rejdak, U. Chyrchel-Paszkiewicz, C. Casanovas Pons, M. Antonia, J. Gamez, M. Salvado, C. Marquez Infante, S. Benitez, M. Lunn, J. Morrow, D. Gosal, T. Lavin, I. Melamed, A. Testori, S. Ajroud-Driss, D. Menichella, E. Simpson, E. Chi-Ho Lai, M. Dimachkie, R. J. Barohn, S. Beydoun, H. Johl, D. Lange, A. Shtilbans, S. Muley, S. Ladha, M. Freimer, J. Kissel, N. Latov, R. Chin, E. Ubogu, S. Mumfrey, T. Rao, P. MacDonald, K. Sharma, G. Gonzalez, J. Allen, D. Walk, L. Hobson-Webb, K. Gable
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Article
Clinical Neurology
Ingemar S. J. Merkies, Ivo N. van Schaik, Jean-Marc Leger, Vera Bril, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Gen Sobue, John-Philip Lawo, Billie L. Durn, David R. Cornblath, Jan L. De Bleecker, Claudia Sommer, Wim Robberecht, Mika Saarela, Jerzy Kamienowski, Zbigniew Stelmasiak, Bjoern Tackenberg, Orell Mielke, A. Sabet, K. George, L. Roberts, R. Carne, S. Blum, R. Henderson, P. Van Damme, J. Demeestere, S. Larue, C. D'Amour, P. Kunc, M. Valis, J. Sussova, T. Kalous, R. Talab, M. Bednar, T. Toomsoo, I. Rubanovits, K. Gross-Paju, U. Sorro, M. Saarela, M. Auranen, J. Pouget, S. Attarian, G. Le Masson, A. Wielanek-Bachelet, C. Desnuelle, E. Delmont, P. Clavelou, D. Aufauvre, J. Schmidt, J. Zschuentzsch, C. Sommer, D. Kramer, O. Hoffmann, C. Goerlitz, J. Haas, M. Chatzopoulos, R. Yoon, R. Gold, P. Berlit, A. Jaspert-Grehl, D. Liebetanz, A. Kutschenko, M. Stangel, C. Trebst, P. Baum, F. Bergh, J. Klehmet, A. Meisel, F. Klostermann, J. Oechtering, H. Lehmann, M. Schroeter, T. Hagenacker, D. Mueller, A. Sperfeld, F. Bethke, V. Drory, A. Algom, D. Yarnitsky, B. Murinson, A. Di Muzio, F. Ciccocioppo, S. Sorbi, S. Mata, A. Schenone, M. Grandis, G. Lauria, D. Cazzato, G. Antonini, S. Morino, D. Cocito, M. Zibetti, T. Yokota, T. Ohkubo, T. Kanda, M. Kawai, K. Kaida, H. Onoue, S. Kuwabara, M. Mori, M. Iijima, K. Ohyama, M. Baba, M. Tomiyama, K. Nishiyama, T. Akutsu, K. Yokoyama, K. Kanai, I. N. van Schaik, F. Eftimov, N. C. Notermans, N. Visser, C. Faber, J. Hoeijmakers, K. Rejdak, U. Chyrchel-Paszkiewicz, C. Casanovas Pons, M. Antonia, J. Gamez, M. Salvado, C. Marquez Infante, S. Benitez, M. Lunn, J. Morrow, D. Gosal, T. Lavin, I. Melamed, A. Testori, S. Ajroud-Driss, D. Menichella, Simpson, E. Chi-Ho Lai, M. Dimachkie, R. J. Barohn, S. Beydoun, H. Johl, D. Lange, A. Shtilbans, S. Muley, S. Ladha, M. Freimer, J. Kissel, N. Latov, R. Chin, E. Ubogu, S. Mumfrey, T. Rao, P. MacDonald, K. Sharma, G. Gonzalez, J. Allen, D. Walk, L. Hobson-Webb, K. Gable, J. L. De Bleecker, M. Saarela, J. Franques, J. -M. Leger, R. Juntas Morales, C. Sommer, A. Nguento, J. Schmidt, Ch. Schrey, J. Kamienowski, Z. Stelmasiak, G. Zwolinska
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Article
Clinical Neurology
Xuan Ouyang, Chaoling Dong, Eroboghene E. Ubogu
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Article
Clinical Neurology
Ivo N. van Schaik, Orell Mielke, Vera Bril, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Gen Sobue, John-Philip Lawo, Michaela Praus, Billie L. Durn, David R. Cornblath, Ingemar S. J. Merkies, A. Sabet, K. George, L. Roberts, R. Carne, S. Blum, R. Henderson, P. Van Damme, J. Demeestere, S. Larue, C. D'Amour, V Bril, A. Breiner, P. Kunc, V Michal, J. Sussova, K. Tomas, R. Talab, B. Michal, T. Toomsoo, I Rubanovits, K. Gross-Paju, U. Sorro, M. Saarela, M. Auranen, J. Pouget, S. Attarian, G. Le Masson, A. Wielanek-Bachelet, C. Desnuelle, E. Delmont, P. Clavelou, D. Aufauvre, J. Schmidt, J. Zschumtszsch, C. Sommer, D. Kramer, O. Hoffmann, C. Goerlitz, J. Haas, M. Chatzopoulos, R. Yoon, R. Gold, P. Berlit, A. Jaspert-Grehl, D. Liebetanz, A. Kutschenko, M. Stangel, C. Trebst, P. Baum, F. Bergh, J. Klehmet, A. Meisel, F. Klostermann, J. Oechtering, H. Lehmann, M. Schroeter, T. Hagenacker, D. Mueller, A. Sperfeld, F. Bethke, V Drory, A. Algom, D. Yarnitsky, B. Murinson, A. Di Muzio, F. Ciccocioppo, S. Sorbi, S. Mata, A. Schenone, M. Grandis, G. Lauria, D. Cazzato, G. Antonini, S. Morino, D. Cocito, M. Zibetti, T. Yokota, T. Ohkubo, T. Kanda, M. Kawai, K. Kaida, H. Onoue, S. Kuwabara, M. Mori, M. Iijima, K. Ohyama, M. Baba, M. Tomiyama, K. Nishiyama, T. Akutsu, K. Yokoyama, K. Kanai, I. N. van Schaik, F. Eftimov, N. C. Notermans, N. Visser, C. Faber, J. Hoeijmakers, K. Rejdak, U. Chyrchel-Paszkiewicz, C. Casanovas Pons, M. Antonia, J. Gamez, M. Salvado, C. Marquez Infante, S. Benitez, M. Lunn, J. Morrow, D. Gosal, T. Lavin, I Melamed, A. Testori, S. Ajroud-Driss, D. Menichella, E. Simpson, E. Chi-Ho Lai, M. Dimachkie, R. J. Barohn, S. Beydoun, H. Johl, D. Lange, A. Shtilbans, S. Muley, S. Ladha, M. Freimer, J. Kissel, N. Latov, R. Chin, E. Ubogu, S. Mumfrey, T. Rao, P. MacDonald, K. Sharma, G. Gonzalez, J. Allen, D. Walk, L. Hobson-Webb, K. Gable
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2019)
Review
Neurosciences
Eroboghene E. Ubogu
EXPERIMENTAL NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
Mohamed Kazamel, Michael Lopez, Eroboghene E. Ubogu
ANNALS OF NEUROLOGY
(2019)
Meeting Abstract
Clinical Neurology
Michael Rivner, Brandy Quarles, Jin-Xiu Pan, Zheng Yu, James Howard, Andrea Corse, Mazen Dimachkie, Carlayne Jackson, Tuan Vu, George Small, Robert Lisak, Jerry Belsh, Ikjae Lee, Vanessa Baute, Stephen Scelsa, J. Americo Fernandes, Zachary Simmons, Andrea Swenson, Richard Barohn, R. Bhavaraju-Sanka, Clifton Gooch, Eroboghene Ubogu, James Caress, Lin Mei
Meeting Abstract
Clinical Neurology
Nan Jiang, Eroboghene Ubogu
Meeting Abstract
Neurosciences
Steven Palladino, Eric Scott Helton, Chaoling Dong, Eroboghene Ubogu
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Article
Medicine, Research & Experimental
Chaoling Dong, Eroboghene E. Ubogu
Article
Medicine, Research & Experimental
Chaoling Dong, E. Scott Helton, Ping Zhou, Xuan Ouyang, Xavier d Anglemont de Tassigny, Alberto Pascual, Jose Lopez-Barneo, Eroboghene E. Ubogu
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)