Bacterial interference with canonical NF B signalling

TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis

(2014) M. Leendertse et al.   JOURNAL OF IMMUNOLOGY

Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF- B, Suppresses I B  Ubiquitination and Modulates Innate Immune Responses

(2014) G. Le Negrate et al.   JOURNAL OF IMMUNOLOGY

The Legionella pneumophila EnhC Protein Interferes with Immunostimulatory Muramyl Peptide Production to Evade Innate Immunity

(2012) Mingyu Liu et al.   Cell Host & Microbe

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Staphylococcal Superantigen-Like Protein 3 Binds to the Toll-Like Receptor 2 Extracellular Domain and Inhibits Cytokine Production Induced by Staphylococcus aureus, Cell Wall Component, or Lipopeptides in Murine Macrophages

(2012) Ryosuke Yokoyama et al.   INFECTION AND IMMUNITY

Functional Differences and Interactions between the Escherichia coli Type III Secretion System Effectors NleH1 and NleH2

(2012) Thanh H. Pham et al.   INFECTION AND IMMUNITY

Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and Increased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice

(2012) M. E. Pennini et al.   JOURNAL OF IMMUNOLOGY

Interleukin 1 Receptor–Associated Kinase M Impairs Host Defense During Pneumococcal Pneumonia

(2012) Gerritje J. W. van der Windt et al.   JOURNAL OF INFECTIOUS DISEASES

Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3

(2012) B. W. Bardoel et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague

(2012) A. M. Spear et al.   MICROBIOLOGY-SGM

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

(2012) Takahito Sanada et al.   NATURE

Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs

(2012) Dapeng Yan et al.   NATURE IMMUNOLOGY

Objective assessment of cancer genes for drug discovery

(2012) Mishal N. Patel et al.   NATURE REVIEWS DRUG DISCOVERY

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

(2012) J.-P. Motta et al.   Science Translational Medicine

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300

(2011) Stephanie R. Shames et al.   CELLULAR MICROBIOLOGY

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

(2011) Simone Nish et al.   IMMUNITY

Mycobacterium tuberculosis Hip1 Dampens Macrophage Proinflammatory Responses by Limiting Toll-Like Receptor 2 Activation

(2011) Ranjna Madan-Lala et al.   INFECTION AND IMMUNITY

A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice

(2011) Teri L. Kissner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klebsiella pneumoniaeOuter Membrane Protein A Is Required to Prevent the Activation of Airway Epithelial Cells

(2011) Catalina March et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

(2011) Eunshil Jeong et al.   YONSEI MEDICAL JOURNAL

LnaB: a Legionella pneumophila activator of NF-κB

(2010) Vicki P. Losick et al.   CELLULAR MICROBIOLOGY

TIR domain-containing adaptor SARM is a late addition to the ongoing microbe–host dialog

(2010) Qing Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine

(2010) Amlan Biswas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skin Commensals Amplify the Innate Immune Response to Pathogens by Activation of Distinct Signaling Pathways

(2010) Ines Wanke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

(2010) Jiankun Zhu et al.   MEDIATORS OF INFLAMMATION

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence

(2010) Manisha Yadav et al.   PLoS Pathogens

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens

Pathogen recognition in the innate immune response

(2009) Himanshu Kumar et al.   BIOCHEMICAL JOURNAL

The nuclear signaling of NF-κB: current knowledge, new insights and future perspectives

(2009) Fengyi Wan et al.   CELL RESEARCH

The Role of Toll-Like Receptor Signaling in Human Immunodeficiencies

(2009) Hanna Suhir et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

(2009) Acacia Lamb et al.   EMBO REPORTS

Critical Role of NOD2 in Regulating the Immune Response to Staphylococcus aureus

(2009) H. S. Deshmukh et al.   INFECTION AND IMMUNITY

Enterococcus faecalis Capsular Polysaccharide Serotypes C and D and Their Contributions to Host Innate Immune Evasion

(2009) L. R. Thurlow et al.   INFECTION AND IMMUNITY

BrucellaTIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP

(2009) Girish K. Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bordetellaevades the host immune system by inducing IL-10 through a type III effector, BopN

(2009) Kanna Nagamatsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subversion of Innate Immune Responses by Brucella through the Targeted Degradation of the TLR Signaling Adapter, MAL

(2009) D. Sengupta et al.   JOURNAL OF IMMUNOLOGY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection

(2009) Cristina Cigana et al.   PLoS One

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial TIR domains: not necessarily agents of subversion?

(2009) Abigail M. Spear et al.   TRENDS IN MICROBIOLOGY

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

(2009) Xiaofei Gao et al.   PLoS Pathogens

The bacterial superantigen and superantigen-like proteins

(2008) John D. Fraser et al.   IMMUNOLOGICAL REVIEWS

CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells

(2008) Hortense Slevogt et al.   NATURE IMMUNOLOGY

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins

(2008) Christine Cirl et al.   NATURE MEDICINE

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

(2008) Suzana P. Salcedo et al.   PLoS Pathogens

Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function

(2008) G. Hajishengallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA