Article
Biochemistry & Molecular Biology
Fanglei Zuo, Tanvi Somiah, Hanna G. G. Gebremariam, Ann-Beth Jonsson
Summary: This study investigated the effect of Lactobacillus culture supernatants on the expression of transcriptional regulators in H. pylori. The results showed that some lactobacilli can downregulate the expression of transcriptional regulators involved in motility, acid tolerance, and LL-37 sensitivity of H. pylori.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Sebastian Suerbaum, Nina Coombs, Lubna Patel, Dimitri Pscheniza, Katharina Rox, Christine Falk, Achim D. Gruber, Olivia Kershaw, Patrick Chhatwal, Mark Broenstrup, Ursula Bilitewski, Christine Josenhans
Summary: This study developed a novel screening system for inhibitors of H. pylori motility and flagellar assembly, and identified numerous novel antibacterial and anti-motility compounds (antimotilins). One of the antimotilin compounds showed good efficacy in reducing bacterial colonization in a mouse model, indicating its potential as a therapy against H. pylori infection.
Article
Biology
Jyot D. Antani, Anita X. Sumali, Tanmay P. Lele, Pushkar P. Lele
Summary: The chemotaxis network in Helicobacter pylori regulates the direction of rotation in the bacterial flagellar motor to facilitate cell migration towards favorable chemical environments. This modulation results in cells swimming faster or slower depending on the direction of flagellar rotation. Exposure to a chemo-attractant decreases the rotational bias, leading to cells swimming exclusively in the faster mode, while the absence of the chemotaxis protein CheY results in a zero bias. The relationship between reversal frequency and rotational bias is unimodal in this species.
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daniela Eletto, Megi Vllahu, Fatima Mentucci, Pasquale Del Gaudio, Antonello Petrella, Amalia Porta, Alessandra Tosco
Summary: H. pylori infection is a major risk factor for gastric cancer development, with TFF1 playing a protective role by affecting the aggregation and motility of the bacterium, as well as reducing gene transcription. This interaction may explain the persistent presence of H. pylori in the human host without causing disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ruben Casatejada-Anchel, Jesus Munoz-Bertomeu, Sara Rosa-Tellez, Armand D. Anoman, Sergio G. Nebauer, Alejandro Torres-Moncho, Alisdair R. Fernie, Roc Ros
Summary: The Phosphorylated Pathway of Serine Biosynthesis (PPSB) plays a crucial role in plant growth and metabolism, with PGDH2 and PGDH3 impacting plant development. PGDH2 has a stronger effect on plant growth compared to PGDH3, while the latter may have additional functions in photosynthetic cells.
Article
Medicine, Research & Experimental
Zong-Bao Yan, Jin-Yu Zhang, Yi-Pin Lv, Wen-Qing Tian, Zhi-Guo Shan, Fang-Yuan Mao, Yu-Gang Liu, Wan-Yan Chen, Pan Wang, Yun Yang, Ping Cheng, Liu-Sheng Peng, Ya-Ling Liao, Geng-Yu Yue, Xiao-Lin Xu, Yong-Liang Zhao, Mu-Han Lu, Yuan Zhuang
Summary: The study found that REDD1 is increased in the gastric mucosa of H. pylori-infected patients and mice. H. pylori induced GECs to express REDD1 via the phosphorylated cagA, activating the MAPKp38 pathway. In Redd1-/- mice, gastric inflammation, MHCII+ monocyte infiltration, IL-23, and IL-17A were all attenuated.
Article
Food Science & Technology
Sebastian Diechler, Bianca E. Chichirau, Gernot Posselt, Dionyssios N. Sgouras, Silja Wessler
Summary: Research has shown that the diverse structure of CagA regulates B cell physiology, while B cell survival is independent of CagA.
Article
Medicine, General & Internal
Gracia Ma Martin-Nunez, Isabel Cornejo-Pareja, Mercedes Clemente-Postigo, Francisco J. Tinahones, Isabel Moreno-Indias
Summary: Eradication treatment for H. pylori leads to changes in gut microbiota composition and a decrease in ghrelin levels. Specific gut bacteria have been linked to changes in ghrelin levels, suggesting a potential role in the regulation of ghrelin.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Thomas M. Steiner, Clara Lettl, Franziska Schindele, Werner Goebel, Rainer Haas, Wolfgang Fischer, Wolfgang Eisenreich
Summary: This study investigated the carbon fluxes through the citrate cycle (TCA cycle) in Helicobacter pylori. It found that glucose was efficiently converted into glyceraldehyde but less into TCA cycle-related metabolites, while glutamate, succinate, and aspartate were incorporated at high levels into intermediates of the TCA cycle. The findings suggest an adaptive TCA cycle with rapid equilibrium fluxes and carbon fluxes via a glyoxylate bypass.
MOLECULAR MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Taoying Wu, Guangqiang Wang, Hongyu Tang, Zhiqiang Xiong, Xin Song, Yongjun Xia, Phoency F-H Lai, Lianzhong Ai
Summary: The adhesion ability of Lactiplantibacillus AR113 series strains is affected by bsh, with different bsh impacting their growth and adaptation to different exogenous substances.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Microbiology
Satoshi Imai, Takuya Ooki, Naoko Murata-Kamiya, Daisuke Komura, Kamrunnesa Tahmina, Weida Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Akiko Kunita, Nobumi Suzuki, Adriana A. Del Valle, Mayo Tsuboi, Masahiro Hata, Yoku Hayakawa, Naomi Ohnishi, Koji Ueda, Masashi Fukayama, Tetsuo Ushiku, Shumpei Ishikawa, Masanori Hatakeyama
Summary: Infection with CagA-producing H. pylori leads to gastric cancer development through disrupting DNA repair mechanisms, inhibiting apoptosis of damaged cells, and promoting somatic mutation. This hit-and-run mechanism creates a favorable environment for the initiation and progression of gastric carcinogenesis.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Michelle C. C. Lim, Gunter Maubach, Anna M. Birkl-Toeglhofer, Johannes Haybaeck, Michael Vieth, Mchael Naumann
Summary: This study found that infection by Helicobacter pylori activates both classical and alternative NF-κB pathways in gastric epithelial cells, leading to inflammation and cell survival. The A20 protein negatively regulates the alternative NF-κB signaling by interfering with the association between TIFA and the NIK regulatory complex. The alternative NF-κB pathway is involved in the up-regulation of anti-apoptotic genes and the over-expression of RelB is associated with the suppression of apoptotic cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Kai-Yuan Yang, Cheng-Yen Kao, Marcia Shu-Wei Su, Shuying Wang, Yueh-Lin Chen, Shiau-Ting Hu, Jenn-Wei Chen, Ching-Hao Teng, Pei-Jane Tsai, Jiunn-Jong Wu
Summary: This study focused on characterizing a putative glycosyltransferase jhp0106 involved in flagellar formation of Helicobacter pylori. The results showed that loss of flagellar formation in the Delta jhp0106 mutant was associated with non-glycosylated FlaA, and identified three active site residues of Jhp0106 within a potential substrate-binding region. The study demonstrated that Jhp0106 (PseE) mediates FlaA glycosylation and flagellar formation, revealing a new glycosyltransferase family responsible for flagellin glycosylation in pathogens.
Article
Oncology
Yang Zhang, Duo Chen, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wei-Cheng You, Kai-Feng Pan
Summary: This study identified potential H.pylori-associated methylation biomarkers in blood leukocyte and gastric mucosa, showing that GNAS and MTERFI methylation levels may be affected by H.pylori infection. GNAS may be involved in the advanced stage of gastric cancer development, with a negative relationship found between GNAS methylation and mRNA expression as well as worse survival outcomes in GC cases with higher GNAS expression levels.