Toxin Plasmids of Clostridium perfringens

Identification of Accessory Genome Regions in Poultry Clostridium perfringens Isolates Carrying the netB Plasmid

(2013) D. Lepp et al.   JOURNAL OF BACTERIOLOGY

Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens

(2013) X.-X. Yan et al.   mBio

Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin

(2013) A. Shrestha et al.   mBio

Identification of a lambda toxin-negative Clostridium perfringens strain that processes and activates epsilon prototoxin intracellularly

(2012) Justine M. Harkness et al.   ANAEROBE

Freezing or adding trypsin inhibitor to equine intestinal contents extends the lifespan of Clostridium perfringens beta toxin for diagnostic purposes

(2012) Melissa Macias Rioseco et al.   ANAEROBE

A Wide Variety of Clostridium perfringens Type A Food-Borne Isolates That Carry a ChromosomalcpeGene Belong to One Multilocus Sequence Typing Cluster

(2012) Yinghua Xiao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clostridium perfringens α-Toxin and NetB Toxin Antibodies and Their Possible Role in Protection Against Necrotic Enteritis and Gangrenous Dermatitis in Broiler Chickens

(2012) K. W. Lee et al.   AVIAN DISEASES

Identification of Amino Acids Important for Binding of Clostridium perfringens Epsilon Toxin to Host Cells and to HAVCR1

(2012) Susan E. Ivie et al.   BIOCHEMISTRY

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

(2012) Michelle A Dunstone et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification of the Cellular Receptor of Clostridium spiroforme Toxin

(2012) Panagiotis Papatheodorou et al.   INFECTION AND IMMUNITY

Role of the Agr-Like Quorum-Sensing System in Regulating Toxin Production by Clostridium perfringens Type B Strains CN1793 and CN1795

(2012) Jianming Chen et al.   INFECTION AND IMMUNITY

Genotypic and Phenotypic Characterization of Clostridium perfringens Isolates from Darmbrand Cases in Post-World War II Germany

(2012) Menglin Ma et al.   INFECTION AND IMMUNITY

Cysteine-Scanning Mutagenesis Supports the Importance of Clostridium perfringens Enterotoxin Amino Acids 80 to 106 for Membrane Insertion and Pore Formation

(2012) Jianwu Chen et al.   INFECTION AND IMMUNITY

Clostridium perfringensAlpha-toxin Recognizes the GM1a-TrkA Complex

(2012) Masataka Oda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characteristics ofClostridium perfringensTpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells

(2012) Gregor Guttenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin fromClostridium perfringens

(2012) Christos G. Savva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species and the MEK/ERK Pathway Are Involved in the Toxicity of Clostridium perfringens  -Toxin, a Prototype Bacterial Phospholipase C

(2012) L. Monturiol-Gross et al.   JOURNAL OF INFECTIOUS DISEASES

The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens

(2012) Radhika Bantwal et al.   PLASMID

Comparative Genomic Hybridization Analysis Shows Different Epidemiology of Chromosomal and Plasmid-Borne cpe-Carrying Clostridium perfringens Type A

(2012) Päivi Lahti et al.   PLoS One

Sequence of Two Plasmids from Clostridium perfringens Chicken Necrotic Enteritis Isolates and Comparison with C. perfringens Conjugative Plasmids

(2012) Valeria R. Parreira et al.   PLoS One

CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins

(2012) Darran J. Wigelsworth et al.   PLoS One

Oligomerization of Clostridium perfringens Epsilon Toxin Is Dependent upon Caveolins 1 and 2

(2012) Christine M. Fennessey et al.   PLoS One

Bidirectional attack on the actin cytoskeleton. Bacterial protein toxins causing polymerization or depolymerization of actin

(2012) Klaus Aktories et al.   TOXICON

Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens

(2012) Seung I. Jang et al.   VACCINE

The effect of Clostridium perfringens type C strain CN3685 and its isogenic beta toxin null mutant in goats

(2012) J.P. Garcia et al.   VETERINARY MICROBIOLOGY

Genetic relatedness and netB prevalence among environmental Clostridium perfringens strains associated with a broiler flock affected by mild necrotic enteritis

(2012) Björn E. Engström et al.   VETERINARY MICROBIOLOGY

TpeL-producing strains of Clostridium perfringens type A are highly virulent for broiler chicks

(2011) C.F. Coursodon et al.   ANAEROBE

Molecular basis of toxicity of Clostridium perfringens epsilon toxin

(2011) Monika Bokori-Brown et al.   FEBS Journal

Epsilon toxin: a fascinating pore-forming toxin

(2011) Michel R. Popoff   FEBS Journal

Cellular vacuolation induced by Clostridium perfringens epsilon-toxin

(2011) Masahiro Nagahama et al.   FEBS Journal

Development and Application of a Mouse Intestinal Loop Model To Study theIn VivoAction of Clostridium perfringens Enterotoxin

(2011) Justin A. Caserta et al.   INFECTION AND IMMUNITY

The Agr-Like Quorum-Sensing System Regulates Sporulation and Production of Enterotoxin and Beta2 Toxin by Clostridium perfringens Type A Non-Food-Borne Human Gastrointestinal Disease Strain F5603

(2011) Jihong Li et al.   INFECTION AND IMMUNITY

Mechanism ofClostridium perfringensEnterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins

(2011) Anna Veshnyakova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure ofClostridium perfringensEnterotoxin Displays Features of β-Pore-forming Toxins

(2011) Kengo Kitadokoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins

(2011) David C. Briggs et al.   JOURNAL OF MOLECULAR BIOLOGY

Diagnosis of Clostridium Perfringens Intestinal Infections in Sheep and Goats

(2011) Francisco A. Uzal et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Malignant Edema in Postpartum Dairy Cattle

(2011) Jenee S. Odani et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Clostridium perfringens tpeL is expressed during sporulation

(2011) Daniel Paredes-Sabja et al.   MICROBIAL PATHOGENESIS

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

(2011) Corrine J. Porter et al.   MOLECULAR MICROBIOLOGY

Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685

(2011) Jorge E. Vidal et al.   MOLECULAR MICROBIOLOGY

Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens ε-Toxin

(2011) Susan E. Ivie et al.   PLoS One

Identification of Novel Clostridium perfringens Type E Strains That Carry an Iota Toxin Plasmid with a Functional Enterotoxin Gene

(2011) Kazuaki Miyamoto et al.   PLoS One

Evidence for a Prepore Stage in the Action of Clostridium perfringens Epsilon Toxin

(2011) Susan L. Robertson et al.   PLoS One

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections

(2011) F.A. Uzal et al.   VETERINARY MICROBIOLOGY

The VirS/VirR Two-Component System Regulates the Anaerobic Cytotoxicity, Intestinal Pathogenicity, and Enterotoxemic Lethality of Clostridium perfringens Type C Isolate CN3685

(2011) M. Ma et al.   mBio

Epsilon-Toxin Production by Clostridium perfringens Type D Strain CN3718 Is Dependent upon the agr Operon but Not the VirS/VirR Two-Component Regulatory System

(2011) J. Chen et al.   mBio

Necrotic Enteritis-Derived Clostridium perfringens Strain with Three Closely Related Independently Conjugative Toxin and Antibiotic Resistance Plasmids

(2011) T. L. Bannam et al.   mBio

Sialidases Affect the Host Cell Adherence and Epsilon Toxin-Induced Cytotoxicity of Clostridium perfringens Type D Strain CN3718

(2011) Jihong Li et al.   PLoS Pathogens

Clostridial Binary Toxins: Iota and C2 Family Portraits

(2011) Bradley G. Stiles et al.   Frontiers in Cellular and Infection Microbiology

Quantitative Analysis of VirB8−VirB9−VirB10 Interactions Provides a Dynamic Model of Type IV Secretion System Core Complex Assembly

(2010) Durga Sivanesan et al.   BIOCHEMISTRY

Polymer Partitioning and Ion Selectivity Suggest Asymmetrical Shape for the Membrane Pore Formed by Epsilon Toxin

(2010) Ekaterina M. Nestorovich et al.   BIOPHYSICAL JOURNAL

Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI

(2010) Maryse Gibert et al.   CELLULAR MICROBIOLOGY

Rapid Cytopathic Effects of Clostridium perfringens Beta-Toxin on Porcine Endothelial Cells

(2010) C. Gurtner et al.   INFECTION AND IMMUNITY

Characterization of Toxin Plasmids in Clostridium perfringens Type C Isolates

(2010) A. Gurjar et al.   INFECTION AND IMMUNITY

Evaluating the Involvement of Alternative Sigma Factors SigF and SigG in Clostridium perfringens Sporulation and Enterotoxin Synthesis

(2010) J. Li et al.   INFECTION AND IMMUNITY

Clostridium perfringensTpeL Glycosylates the Rac and Ras Subfamily Proteins

(2010) Masahiro Nagahama et al.   INFECTION AND IMMUNITY

The VirSR Two-Component Signal Transduction System Regulates NetB Toxin Production in Clostridium perfringens

(2010) J. K. Cheung et al.   INFECTION AND IMMUNITY

Mega assemblages of oligomeric aerolysin-like toxins stabilized by toxin-associating membrane proteins

(2010) Hiroyasu Shimada et al.   JOURNAL OF BIOCHEMISTRY

Identification of Novel Pathogenicity Loci in Clostridium perfringens Strains That Cause Avian Necrotic Enteritis

(2010) Dion Lepp et al.   PLoS One

Conjugative Botulinum Neurotoxin-Encoding Plasmids in Clostridium botulinum

(2010) Kristin M. Marshall et al.   PLoS One

Organization of the cpe Locus in CPE-Positive Clostridium perfringens Type C and D Isolates

(2010) Jihong Li et al.   PLoS One

In vitro production of necrotic enteritis toxin B, NetB, by netB-positive and netB-negative Clostridium perfringens originating from healthy and diseased broiler chickens

(2010) Lone Abildgaard et al.   VETERINARY MICROBIOLOGY

NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

(2010) Anthony L. Keyburn et al.   Toxins

Necrotic enteritis in chickens: A paradigm of enteric infection by Clostridium perfringens type A

(2009) Kerry K. Cooper et al.   ANAEROBE

Identification of the channel-forming domain of Clostridium perfringens Epsilon-toxin (ETX)

(2009) Oliver Knapp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Contact with enterocyte-like Caco-2 cells induces rapid upregulation of toxin production byClostridium perfringenstype C isolates

(2009) Jorge E. Vidal et al.   CELLULAR MICROBIOLOGY

The NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence

(2009) M. Chiarezza et al.   INFECTION AND IMMUNITY

The Long-Lived Nature of Clostridium perfringens Iota Toxin in Mammalian Cells Induces Delayed Apoptosis

(2009) H. Hilger et al.   INFECTION AND IMMUNITY

Characterization of Virulence Plasmid Diversity among Clostridium perfringens Type B Isolates

(2009) S. Sayeed et al.   INFECTION AND IMMUNITY

Development and Application of New Mouse Models To Study the Pathogenesis of Clostridium perfringens Type C Enterotoxemias

(2009) F. A. Uzal et al.   INFECTION AND IMMUNITY

Identification of a Claudin-4 Residue Important for Mediating the Host Cell Binding and Action of Clostridium perfringens Enterotoxin

(2009) S. L. Robertson et al.   INFECTION AND IMMUNITY

The Putative Coupling Protein TcpA Interacts with Other pCW3-Encoded Proteins To Form an Essential Part of the Conjugation Complex

(2009) J. A. Steen et al.   JOURNAL OF BACTERIOLOGY

Sporulation and Enterotoxin (CPE) Synthesis Are Controlled by the Sporulation-Specific Sigma Factors SigE and SigK in Clostridium perfringens

(2009) K. H. Harry et al.   JOURNAL OF BACTERIOLOGY

Virulence Gene Regulation by the agr System in Clostridium perfringens

(2009) K. Ohtani et al.   JOURNAL OF BACTERIOLOGY

Genetic Characterization of Type A Enterotoxigenic Clostridium perfringens Strains

(2009) Agi Deguchi et al.   PLoS One

Functional Analysis of the VirSR Phosphorelay from Clostridium perfringens

(2009) Jackie K. Cheung et al.   PLoS One

Further Characterization of Clostridium perfringens Small Acid Soluble Protein-4 (Ssp4) Properties and Expression

(2009) Jihong Li et al.   PLoS One

Use of an EZ-Tn5-Based Random Mutagenesis System to Identify a Novel Toxin Regulatory Locus in Clostridium perfringens Strain 13

(2009) Jorge E. Vidal et al.   PLoS One

Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats

(2009) Jorge Goldstein et al.   PLoS One

Association between avian necrotic enteritis andClostridium perfringensstrains expressing NetB toxin

(2009) Anthony L. Keyburn et al.   VETERINARY RESEARCH

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Clostridium perfringens Iota-Toxin: Structure and Function

(2009) Jun Sakurai et al.   Toxins

Clostridium perfringens toxin genotypes in the feces of healthy North Americans

(2008) Robert J. Carman et al.   ANAEROBE

Factors Contributing to Heat Resistance of Clostridium perfringens Endospores

(2008) B. Orsburn et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis

(2008) Azusa Takahashi et al.   BIOCHEMICAL PHARMACOLOGY

Recombinant Attenuated Salmonella enterica Serovar Typhimurium Expressing the Carboxy-Terminal Domain of Alpha Toxin from Clostridium perfringens Induces Protective Responses against Necrotic Enteritis in Chickens

(2008) B. Zekarias et al.   Clinical and Vaccine Immunology

Binary Actin-ADP-Ribosylating Toxins and their Use as Molecular Trojan Horses for Drug Delivery into Eukaryotic Cells

(2008) Holger Barth et al.   CURRENT MEDICINAL CHEMISTRY

The Identification and Characterization of Clostridium perfringens by Real-Time PCR, Location of Enterotoxin Gene, and Heat Resistance

(2008) Kathie A. Grant et al.   Foodborne Pathogens and Disease

Effects of Clostridium perfringens Beta-Toxin on the Rabbit Small Intestine and Colon

(2008) J. E. Vidal et al.   INFECTION AND IMMUNITY

Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity

(2008) J. G. Smedley et al.   INFECTION AND IMMUNITY

Functional Characterization and Localization of the TcpH Conjugation Protein from Clostridium perfringens

(2008) W. L. Teng et al.   JOURNAL OF BACTERIOLOGY

Sequencing and Diversity Analyses Reveal Extensive Similarities between Some Epsilon-Toxin-Encoding Plasmids and the pCPF5603 Clostridium perfringens Enterotoxin Plasmid

(2008) K. Miyamoto et al.   JOURNAL OF BACTERIOLOGY

Clostridium perfringens Delta Toxin Is Sequence Related to Beta Toxin, NetB, and Staphylococcus Pore-Forming Toxins, but Shows Functional Differences

(2008) Maria Manich et al.   PLoS One

NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens

(2008) Anthony L. Keyburn et al.   PLoS Pathogens

Structural basis of Clostridium perfringens toxin complex formation

(2008) J. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens

(2008) Filip Van Immerseel et al.   TRENDS IN MICROBIOLOGY

Prevalence of netB among some clinical isolates of Clostridium perfringens from animals in the United States

(2008) Thomas G. Martin et al.   VETERINARY MICROBIOLOGY

A Novel Small Acid Soluble Protein Variant Is Important for Spore Resistance of Most Clostridium perfringens Food Poisoning Isolates

(2008) Jihong Li et al.   PLoS Pathogens

A prospective study of the roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea

(2007) J. S. WEESE et al.   EQUINE VETERINARY JOURNAL