Toxin-Antitoxin Genes of the Gram-Positive Pathogen Streptococcus pneumoniae: So Few and Yet So Many

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Combat Pneumococcal Infections: Adhesins as Candidates for Protein- Based Vaccine Development

(2012) Gustavo Gamez et al.   CURRENT DRUG TARGETS

Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases

(2012) Luiz Carlos Bertucci Barbosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Stress-Inducible Quorum-Sensing Peptide Mediates the Formation of Persister Cells with Noninherited Multidrug Tolerance

(2012) V. Leung et al.   JOURNAL OF BACTERIOLOGY

Bistability in feedback circuits as a byproduct of evolution of evolvability

(2012) Hiroyuki Kuwahara et al.   Molecular Systems Biology

Kis antitoxin couples plasmid R1 replication and parD (kis,kid) maintenance modules

(2012) Juan López-Villarejo et al.   PLASMID

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica

(2012) Mark Achtman et al.   PLoS Pathogens

Identification, variation and transcription of pneumococcal repeat sequences

(2011) Nicholas J Croucher et al.   BMC GENOMICS

Toxins-antitoxins: diversity, evolution and function

(2011) Finbarr Hayes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genetic Regulation of the yefM-yoeB Toxin-Antitoxin Locus of Streptococcus pneumoniae

(2011) W. T. Chan et al.   JOURNAL OF BACTERIOLOGY

RelE-Mediated Dormancy Is Enhanced at High Cell Density in Escherichia coli

(2011) Y. Tashiro et al.   JOURNAL OF BACTERIOLOGY

An Epigenetic Switch Mediates Bistable Expression of the Type 1 Pilus Genes in Streptococcus pneumoniae

(2011) A. Basset et al.   JOURNAL OF BACTERIOLOGY

ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

(2011) Hannes Mutschler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Temporal competition between differentiation programs determines cell fate choice

(2011) A. Kuchina et al.   Molecular Systems Biology

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

(2011) Yoshihiro Yamaguchi et al.   NATURE REVIEWS MICROBIOLOGY

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

Genomes of the Most Dangerous Epidemic Bacteria Have a Virulence Repertoire Characterized by Fewer Genes but More Toxin-Antitoxin Modules

(2011) Kalliopi Georgiades et al.   PLoS One

A Variable Region within the Genome of Streptococcus pneumoniae Contributes to Strain-Strain Variation in Virulence

(2011) Richard M. Harvey et al.   PLoS One

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opportunity and Means: Horizontal Gene Transfer from the Human Host to a Bacterial Pathogen

(2011) M. T. Anderson et al.   mBio

A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis

(2011) Hannes Mutschler et al.   PLOS BIOLOGY

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Toxin–antitoxin systems: why so many, what for?

(2010) Laurence Van Melderen   CURRENT OPINION IN MICROBIOLOGY

parD toxin-antitoxin system of plasmid R1 - basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems

(2010) Elizabeth Diago-Navarro et al.   FEBS Journal

Exact Results for the Evolution of Stochastic Switching in Variable Asymmetric Environments

(2010) B. Gaal et al.   GENETICS

Bacterial toxin-antitoxin systems targeting translation

(2010) Ramón Díaz-Orejas et al.   Journal of Applied Biomedicine

NoncognateMycobacterium tuberculosisToxin-Antitoxins Can Physically and Functionally Interact

(2010) Ling Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly Dynamics and Stability of the Pneumococcal Epsilon Zeta Antitoxin Toxin (PezAT) System fromStreptococcus pneumoniae

(2010) Hannes Mutschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB

(2010) Qian Tan et al.   MOLECULAR MICROBIOLOGY

RatA (YfjG), an Escherichia coli toxin, inhibits 70S ribosome association to block translation initiation

(2010) Yonglong Zhang et al.   MOLECULAR MICROBIOLOGY

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

(2010) Yucheng Shao et al.   NUCLEIC ACIDS RESEARCH

Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I

(2010) Feng Huang et al.   NUCLEIC ACIDS RESEARCH

The relBE2Spn Toxin-Antitoxin System of Streptococcus pneumoniae: Role in Antibiotic Tolerance and Functional Conservation in Clinical Isolates

(2010) Concha Nieto et al.   PLoS One

Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules

(2010) Min Yang et al.   PLoS One

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New kinase regulation mechanism found in HipBA: a bacterial persistence switch

(2009) Artem Evdokimov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis

(2009) Víctor M. Hernández-Rocamora et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Environmental stress and evolvability in microbial systems

(2009) F. Baquero   CLINICAL MICROBIOLOGY AND INFECTION

In Vivo Interactions between Toxin-Antitoxin Proteins Epsilon and Zeta of Streptococcal Plasmid pSM19035 in Saccharomyces cerevisiae

(2009) U. Zielenkiewicz et al.   JOURNAL OF BACTERIOLOGY

Regulation of the mazEF Toxin-Antitoxin Module in Staphylococcus aureus and Its Impact on sigB Expression

(2009) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

The Inhibitory Mechanism of Protein Synthesis by YoeB, anEscherichia coliToxin

(2009) Yonglong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial persistence: some new insights into an old phenomenon

(2009) R. Jayaraman   JOURNAL OF BIOSCIENCES

Crystal Structure of the Antitoxin–Toxin Protein Complex RelB–RelE from Methanococcus jannaschii

(2009) Djordje Francuski et al.   JOURNAL OF MOLECULAR BIOLOGY

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB

(2009) Martin Overgaard et al.   JOURNAL OF MOLECULAR BIOLOGY

Three new RelE-homologous mRNA interferases ofEscherichia colidifferentially induced by environmental stresses

(2009) Mikkel Christensen-Dalsgaard et al.   MOLECULAR MICROBIOLOGY

Microbial awakenings

(2009) Slava S. Epstein   NATURE

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair

(2009) Peter C. Fineran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyper-Recombination, Diversity, and Antibiotic Resistance in Pneumococcus

(2009) W. P. Hanage et al.   SCIENCE

Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

(2009) M. A. Schumacher et al.   SCIENCE

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

A Toxin–Antitoxin System Promotes the Maintenance of an Integrative Conjugative Element

(2009) Rachel A. F. Wozniak et al.   PLoS Genetics

Highlights of glucosamine-6P synthase catalysis

(2008) Philippe Durand et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases

(2008) Eliane Trovatti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toxin-Antitoxin Systems in Escherichia coli Influence Biofilm Formation through YjgK (TabA) and Fimbriae

(2008) Y. Kim et al.   JOURNAL OF BACTERIOLOGY

HicA of Escherichia coli Defines a Novel Family of Translation-Independent mRNA Interferases in Bacteria and Archaea

(2008) M. G. Jorgensen et al.   JOURNAL OF BACTERIOLOGY

Chromosomal Toxin-Antitoxin Systems May Act as Antiaddiction Modules

(2008) M. Saavedra De Bast et al.   JOURNAL OF BACTERIOLOGY

Role of Conjugative Elements in the Evolution of the Multidrug-Resistant Pandemic Clone Streptococcus pneumoniaeSpain23F ST81

(2008) N. J. Croucher et al.   JOURNAL OF BACTERIOLOGY

Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation

(2008) Abel Garcia-Pino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Mechanism of Transcriptional Autorepression of the Escherichia coli RelB/RelE Antitoxin/Toxin Module

(2008) Guang-Yao Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Small Toxic Proteins and the Antisense RNAs That Repress Them

(2008) E. M. Fozo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Messenger RNA interferase RelE controlsrelBEtranscription by conditional cooperativity

(2008) Martin Overgaard et al.   MOLECULAR MICROBIOLOGY

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit

(2008) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA