Article
Cell Biology
Xiaofan Feng, Tianyi Jiang, Chun Yang, Shujie Pang, Zhiwen Ding, Heping Hu, Hui Wang, Liwei Dong, Ning Yang
Summary: This study reveals that RPRD1A is highly expressed in hepatocellular carcinoma (HCC) and is correlated with aggressive clinicopathological features. RPRD1A competitively interacts with TRIM21 to inhibit the ubiquitination of p62 and increase its sequestration for Keap1, thus enhancing the nuclear translocation of NRF2 and promoting HCC development. Additionally, genetic knockdown of RPRD1A disturbs the redox homeostasis of cancer cells and sensitizes them to platinum-induced cell death.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Fang Wang, Ye Zhang, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q. Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, Wei-Xing Zong
Summary: TRIM21 is involved in hepatocarcinogenesis, with its expression positively correlated with human HCC. Genetic ablation of TRIM21 in mice confers resistance to DEN-induced hepatocarcinogenesis, suggesting TRIM21 as a potential target for preventing and treating liver cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Cell Biology
Jiaming Zhou, Qiuxian Zheng, Zhi Chen
Summary: Oxidative stress is the leading cause of most liver diseases, and the Keap1-Nrf2 system plays a critical role in defense against oxidative stress. Increasing Nrf2 levels can alleviate liver injury and have protective effects in various liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Yinghui Liu, Jingjing Ma, Shimin Lu, Pengzhan He, Weiguo Dong
Summary: This study found that USP25 was overexpressed in hepatocellular carcinoma (HCC) and its high expression was closely associated with poor prognosis. USP25 promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells by interacting with TRIM21 to activate the beta-catenin signaling pathway.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Xue Li, Lin Yang, Si Chen, Jiawei Zheng, Huimin Zhang, Linzhu Ren
Summary: TRIM21, a member of the TRIM family, possesses an E3 ubiquitin ligase activity. Recent studies have shown that TRIM21 is involved in virus infection by interacting with viral proteins or modulating immune and inflammatory responses. TRIM21 also acts as a cytosol high-affinity antibody Fc receptor, triggering antibody-dependent intracellular neutralization (ADIN).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Shuzo Urata, Rokusuke Yoshikawa, Jiro Yasuda
Summary: Calcium ion plays a crucial role in the replication of negative-strand RNA viruses (NSVs). L-type calcium channel blockers have been identified as effective inhibitors of severe fever with thrombocytopenia syndrome virus (SFTSV) replication as well as other NSVs. The results showed that manidipine, an L-type calcium channel blocker, inhibits the formation of SFTSV N-induced inclusion bodies, which are important for viral replication.
JOURNAL OF VIROLOGY
(2023)
Article
Dermatology
Sijia Wang, Xiuli Yi, Zhenjie Wu, Sen Guo, Wei Dai, Huina Wang, Qiong Shi, Kang Zeng, Weinan Guo, Chunying Li
Summary: CAMKK2 regulates the sensitivity of melanoma cells to ferroptosis by modulating the AMPK.NRF2 pathway, potentially playing a crucial role in melanoma treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Virology
Kisho Noda, Yoshimi Tsuda, Fumiya Kozawa, Manabu Igarashi, Kenta Shimizu, Jiro Arikawa, Kumiko Yoshimatsu
Summary: The amino acid characteristics at position 1891 of the L protein are critical for its function, especially with respect to the charge status. Substitutions with basic amino acids enhance polymerase activity, while substitutions with acidic amino acids decrease this activity. Mutations to other neutral amino acids show no significant effect on activity.
Article
Biochemistry & Molecular Biology
Alessia Tognoloni, Desiree Bartolini, Marco Pepe, Antonio Di Meo, Ilaria Porcellato, Kubra Guidoni, Francesco Galli, Elisabetta Chiaradia
Summary: This study investigated the potential antioxidant effects of platelet-rich plasma (PRP) on tenocytes exposed to oxidative stress. The results demonstrated that PRP reduces oxidative damage, protects cells from cell death, and activates various cellular signaling pathways for tendon regeneration and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Wangyang Tan, Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Shun Chen, Anchun Cheng
Summary: This study investigates the interactions between TMUV and autophagy, as well as the effects of TMUV structural and nonstructural proteins on autophagy. The results demonstrate that nonstructural proteins 2B and 4A induce autophagy and interact with SQSTM1/p62. Moreover, complete autophagy plays a vital role in TMUV replication.
VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Steven Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, Jeroen Esselink, Allard van Egmond, Jornt Mos, Joost B. Beltman, Jens Timmer, Bob van de Water, Daniel Kaschek
Summary: This study presents a quantitative dynamic model that accurately describes the dynamic response of cells to oxidative stress. The model can explain the activation of the Nrf2 pathway by compounds with different activation mechanisms, and reveal differences in the activation dynamics of drug-induced liver injury (DILI) inducing drugs.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Stefania Scicchitano, Maria Concetta Faniello, Maria Mesuraca
Summary: The human zinc finger protein 521 (ZNF521) plays a crucial role in the regulation of human ovarian cancer, affecting proliferation, progression, and cancer stem cell properties. This study also reveals the influence of ZNF521 on the NRF2-NOTCH signaling pathway in ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shah Kamranur Rahman, Khamal Kwesi Ampah, Polly Roy
Summary: Liquid-liquid phase separation plays a vital role in subcellular compartment formation in biological cell systems. Research has shown that in virus infected cells, a protein called NS2 undergoes liquid-liquid phase separation, which is dependent on protein phosphorylation and RNA-binding. This interaction between specific arginine residues and RNA drives the occurrence of liquid-liquid phase separation.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Toxicology
Luyao Wang, Fang Sun, Jing Hu, Weimin Zuo, Yi Zheng, Yingliang Wu, Hang Fai Kwok, Zhijian Cao
Summary: The saliva peptide HIDfsin2 promotes the replication of SFTSV by enhancing p38 MAPK activation in A549 cells. Blocking p38 MAPK activation inhibits SFTSV replication.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Cell Biology
Liang Yuh Chew, Heng Zhang, Jianzheng He, Fengwei Yu
Summary: The Nrf2-Keap1 pathway plays a cell-autonomous role in governing neuronal remodeling during Drosophila metamorphosis, activated downstream of the steroid hormone ecdysone. It regulates dendrite pruning through proteasomal degradation, independent of its canonical antioxidant response pathway. This study reveals an epistatic link between the Nrf2-Keap1 pathway and steroid hormone signaling in neuronal remodeling.
Article
Microbiology
Su-Jin Park, Young-Il Kim, Angela Park, Hyeok-Il Kwon, Eun-Ha Kim, Young-Jae Si, Min-Suk Song, Chul-Ho Lee, Kyle Jung, Woo-Jin Shin, Jianxiong Zeng, Younho Choi, Jae U. Jung, Young Ki Choi
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Younho Choi, Su-Jin Park, Yinyan Sun, Ji-Seung Yoo, Raghavendra Sumanth Pudupakam, Suan-Sin Foo, Woo-Jin Shin, Sally B. Chen, Philip N. Tsichlis, Won-Ja Lee, Jong-Soo Lee, Wenhui Li, Benjamin Brennan, Young-Ki Choi, Jae U. Jung
NATURE MICROBIOLOGY
(2019)
Article
Immunology
Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg, Jae U. Jung
Article
Cell Biology
Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yang, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav Zlokovic, Zhen Zhao, Jae U. Jung
Article
Microbiology
Huan Yan, Suan-Sin Foo, Weiqiang Chen, Ji-Seung Yoo, Woo-Jin Shin, Christine Wu, Jae U. Jung
Article
Cell Biology
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Article
Microbiology
Su-Jin Park, Kwang-Min Yu, Young-Il Kim, Se-Mi Kim, Eun-Ha Kim, Seong-Gyu Kim, Eun Ji Kim, Mark Anthony B. Casel, Rare Rollon, Seung-Gyu Jang, Min-Hyeok Lee, Jae-Hyung Chang, Min-Suk Song, Hye Won Jeong, Younho Choi, Weiqiang Chen, Woo-Jin Shin, Jae U. Jung, Young Ki Choi
Article
Chemistry, Medicinal
Sang Hoon Han, Christopher M. Goins, Tarun Arya, Woo-Jin Shin, Joshua Maw, Alice Hooper, Dhiraj P. Sonawane, Matthew R. Porter, Breyanne E. Bannister, Rachel D. Crouch, A. Abigail Lindsey, Gabriella Lakatos, Steven R. Martinez, Joseph Alvarado, Wendell S. Akers, Nancy S. Wang, Jae U. Jung, Jonathan D. Macdonald, Shaun R. Stauffer
Summary: Starting from ML300, a structure-based optimization campaign was conducted against the SARS-CoV-2 main protease, resulting in the discovery of compound 41 with antiviral activity. This study provides important insights for the development of antiviral drugs in combating SARS-like coronavirus outbreaks.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Xin Wu, Tian Xia, Woo-Jin Shin, Kwang-Min Yu, Wooram Jung, Alexandra Herrmann, Suan-Sin Foo, Weiqiang Chen, Pengfei Zhang, Jong-Soo Lee, Haryoung Poo, Suzy A. A. Comhair, Lara Jehi, Young Ki Choi, Armin Ensser, Jae U. Jung
Summary: Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have milder infection and disease outcome. The study reveals that secreted ORF8 protein mimics host IL-17 to activate IL-17 receptors A and C, inducing a stronger inflammatory response than host IL-17A. This provides molecular insights into the role of ORF8 in COVID-19 pathogenesis and serves as a potential therapeutic target.
Letter
Multidisciplinary Sciences
Woo-Jin Shin, Dat P. Ha, Keigo Machida, Amy S. Lee
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Suan-Sin Foo, Mary Catherine Cambou, Thalia Mok, Viviana M. Fajardo, Kyle L. Jung, Trevon Fuller, Weiqiang Chen, Tara Kerin, Jenny Mei, Debika Bhattacharya, Younho Choi, Xin Wu, Tian Xia, Woo-Jin Shin, Jessica Cranston, Grace Aldrovandi, Nicole Tobin, Deisy Contreras, Francisco J. Ibarrondo, Otto Yang, Shangxin Yang, Omai Garner, Ruth Cortado, Yvonne Bryson, Carla Janzen, Shubhamoy Ghosh, Sherin Devaskar, Brenda Asilnejad, Maria Elisabeth Moreira, Zilton Vasconcelos, Priya R. Soni, L. Caroline Gibson, Patricia Brasil, Suzy A. A. Comhair, Vaithilingaraja Arumugaswami, Serpil C. Erzurum, Rashmi Rao, Jae U. Jung, Karin Nielsen-Saines
Summary: Pregnancy increases the risk for severe COVID-19, but the effects of COVID-19 on maternal-fetal health are still unknown. Research shows that prenatal SARS-CoV-2 infection triggers immune activation, severe COVID-19 patients exhibit heightened inflammation, and COVID-19 affects maternal immunity and newborns differently.
CELL REPORTS MEDICINE
(2021)