Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Zhi-Yuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Wan Jin, Hong-Mei Ren, Sheng-Yao Kuang, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Xiao-Qiu Zhou
Summary: This study focused on the protective effects of dietary mannoligosaccharides (MOS) supplementation on the intestinal structural integrity of grass carp. The results showed that dietary MOS supplementation protected the microvillus of the intestine, reduced mucosal permeability, and maintained intestinal structural integrity through the inhibition of MLCK and RhoA/ROCK signaling pathways. These findings highlight the positive impact of dietary MOS supplementation on intestinal health.
Article
Plant Sciences
Mi Ri Kim, Su-Yeon Cho, Hee Ju Lee, Joo Yeon Kim, Uyen Tran Tu Nguyen, Ngoc Minh Ha, Ki Young Choi, Kwang Hyun Cha, Jeong-Ho Kim, Won Kyu Kim, Kyungsu Kang
Summary: Schisandrin C improves intestinal barrier formation and permeability dysfunction by regulating TJ protein expression and signaling pathways. This study is important for understanding the mechanisms of intestinal inflammation and permeability disorders and exploring new therapeutic approaches.
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Yi Zhou, Ling Duan, Yan Zeng, Xu Song, Kangcheng Pan, Lili Niu, Yang Pu, Jiakun Li, Abdul Khalique, Jing Fang, Bo Jing, Dong Zeng, Bairong Shen, Xueqin Ni
Summary: The intestinal microbiota of captive pandas, characterized by a high abundance of Enterobacteriaceae, has led to intestinal infection. Probiotic supplement Lactiplantibacillus plantarum BSG201683 (L. plantarum G83) has shown effectiveness in improving intestinal barrier function and inflammation. In vitro studies demonstrated that L. plantarum G83 reduced paracellular permeability, decreased proinflammatory cytokines, and enhanced anti-inflammatory responses through Toll-like receptor 4/ nuclear factor kappa-B (TLR4/NF-?B) signaling pathways.
Article
Biochemistry & Molecular Biology
Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Jin
Summary: Exposure to chlorothalonil (CTL) can induce structural and functional damage to the human IEB, leading to barrier dysfunction through the activation of the mitogen-activated protein kinase pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Environmental Sciences
Ha-Young Park, Jin-Hee Yu
Summary: This study investigated the effects of radiation on TJ-related proteins in an intestinal epithelial cell model. The results showed that X-ray exposure reduced cell viability, proliferation, and growth rate, while increasing intestinal permeability. The expression of TJ-related genes and proteins was also downregulated.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Prashant Nighot, Thomas Ma
Summary: Eukaryotic cells internalize macromolecules and particles through endocytosis, while the epithelial tight junctions regulate cell adhesion and paracellular pathways by dynamically controlling the presence of proteins within the junction complex. This regulation is crucial for responding to various signals both intracellularly and extracellularly.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Longxian Lv, Xiaoyuan Bian, Liya Yang, Jiafeng Xia, Xianwan Jiang, Wenrui Wu, Shuting Wang, Qiangqiang Wang, Lanjuan Li
Summary: Ketogenic diet worsens DSS-induced colitis in mice by increasing inflammation, disrupting the intestinal barrier, and modulating gut microbiota and metabolism.
Article
Cell Biology
Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Vikash Singh, Aayush Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot
Summary: This study revealed that increased clathrin-mediated endocytosis under starvation conditions promotes degradation of CLDN2 and enhances the TJ barrier. The association of CLDN2 with clathrin and AP2 as well as LC3 and lysosomes increased upon starvation, indicating the role of clathrin-mediated endocytosis in autophagy-induced CLDN2 degradation.
Article
Biochemistry & Molecular Biology
Nurainina Ayob, Khairul Najmi Muhammad Nawawi, Mohamad Hizami Mohamad Nor, Raja Affendi Raja Ali, Hajar Fauzan Ahmad, Seok Fang Oon, Norfilza Mohd Mokhtar
Summary: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing, and the role of the gut-liver axis (GLA) in NAFLD pathophysiology is becoming more apparent. In this study, we focused on the small intestinal area to investigate the effect of multi-strain probiotics on the gut microbiota, inflammatory cytokines, and permeability in NAFLD patients. After six months of supplementation, the probiotics group showed significant changes in microbiota composition and a decrease in certain unclassifiable species. Inflammatory cytokines were also affected, with a decrease in IFN-gamma and TNF-alpha but an increase in IL-6.
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)