Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

(2012) Dandan Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement

(2012) Di Huang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Flux variability scanning based on enforced objective flux for identifying gene amplification targets

(2012) Jong Park et al.   BMC Systems Biology

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

(2012) C. Barreiro et al.   JOURNAL OF BACTERIOLOGY

Computational identification of gene over-expression targets for metabolic engineering of taxadiene production

(2011) Brett A. Boghigian et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent advances in reconstruction and applications of genome-scale metabolic models

(2011) Tae Yong Kim et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA

(2011) Peng Xu et al.   METABOLIC ENGINEERING

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

(2011) Jan Schellenberger et al.   Nature Protocols

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis

(2010) Catriona J Harper et al.   BMC MICROBIOLOGY

OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

(2010) Joonhoon Kim et al.   BMC Systems Biology

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative analysis and engineering of fatty acid biosynthesis in E. coli

(2010) Tiangang Liu et al.   METABOLIC ENGINEERING

Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster

(2010) Jette Thykaer et al.   METABOLIC ENGINEERING

Manipulating redox and ATP balancing for improved production of succinate in E. coli

(2010) Amarjeet Singh et al.   METABOLIC ENGINEERING

Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification

(2010) Tuty Kadir et al.   Microbial Cell Factories

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

(2010) Sridhar Ranganathan et al.   PLoS Computational Biology

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

(2009) Z. L. Fowler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis

(2009) Yun Xia Duan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways

(2009) N. Tepper et al.   BIOINFORMATICS

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

(2009) Mohammad A. Asadollahi et al.   METABOLIC ENGINEERING

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering

(2009) Wenjuan Zha et al.   METABOLIC ENGINEERING

Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering

(2009) Joseph A. Chemler et al.   METABOLIC ENGINEERING

Corynebacterium glutamicum Contains 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthases That Display Novel Biochemical Features

(2008) Y.-J. Liu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotic Overproduction inStreptomyces coelicolorA3(2) Mediated by Phosphofructokinase Deletion

(2008) Irina Borodina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways

(2008) Irene Martínez et al.   METABOLIC ENGINEERING