Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells

Ruthenium(ii) and osmium(ii) 1,2,3-triazolylidene organometallics: a preliminary investigation into the biological activity of ‘click’ carbene complexes

(2013) Kelly J. Kilpin et al.   DALTON TRANSACTIONS

Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation

(2013) Isolda Romero-Canelón et al.   INORGANIC CHEMISTRY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway

(2013) Isolda Romero-Canelón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Management of non-small-cell lung cancer: recent developments

(2013) Martin Reck et al.   LANCET

A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma

(2013) A Maillet et al.   Cell Death & Disease

Management of Small Cell Lung Cancer

(2012) Raffaele Califano et al.   DRUGS

Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes

(2012) Isolda Romero-Canelón et al.   Metallomics

Anticancer Activity of Metal Complexes: Involvement of Redox Processes

(2011) Ute Jungwirth et al.   ANTIOXIDANTS & REDOX SIGNALING

Transition Metal Based Anticancer Drugs

(2011) K. Benjamin Garbutcheon-Singh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity

(2011) Ying Fu et al.   DALTON TRANSACTIONS

En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity oftrans-[OsIVCl4(Hazole)2]

(2011) Gabriel E. Büchel et al.   INORGANIC CHEMISTRY

Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes

(2011) Katherine Ann Price et al.   INORGANIC CHEMISTRY

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

(2011) Steve D. Shnyder et al.   MedChemComm

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

(2010) Tianfeng Chen et al.   INORGANIC CHEMISTRY

Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity

(2010) Ying Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

(2009) Sabine H. van Rijt et al.   DRUG DISCOVERY TODAY

Organometallic Osmium(II) Arene Anticancer Complexes Containing Picolinate Derivatives

(2009) Sabine H. van Rijt et al.   INORGANIC CHEMISTRY

Synthesis, Properties, and Live-Cell Imaging Studies of Luminescent Cyclometalated Iridium(III) Polypyridine Complexes Containing Two or Three Biotin Pendants

(2009) Kenneth Yin Zhang et al.   INORGANIC CHEMISTRY

Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes

(2009) Sabine H. van Rijt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxicity, Hydrophobicity, Uptake, and Distribution of Osmium(II) Anticancer Complexes in Ovarian Cancer Cells

(2009) Sabine H. van Rijt et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA Interactions of Monofunctional Organometallic Osmium(II) Antitumor Complexes in Cell-Free Media

(2008) Hana Kostrhunova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I)N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols

(2008) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY