Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

The transition metals copper and iron in neurodegenerative diseases

(2010) Susana Rivera-Mancía et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gene–Environment Interactions in Parkinson's Disease: The Importance of Animal Modeling

(2010) M P Horowitz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models

(2010) Suvi Asikainen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

(2010) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

(2010) Roongpetch Keowkase et al.   NEUROPHARMACOLOGY

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

(2010) Natalia VanDuyn et al.   TOXICOLOGICAL SCIENCES

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

(2010) Mingwei Ni et al.   TOXICOLOGICAL SCIENCES

Hormetic effect of methylmercury on Caenorhabditis elegans

(2010) Kirsten J. Helmcke et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

Exposure to Lead and Mercury in Young Larvae Induces More Severe Deficits in Neuronal Survival and Synaptic Function than in Adult Nematodes

(2009) X.-J. Xing et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Copper and Zinc Binding to Amyloid-β: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer

(2009) Peter Faller   CHEMBIOCHEM

Manganese-Induced Dopaminergic Neurodegeneration: Insights into Mechanisms and Genetics Shared with Parkinson’s Disease

(2009) Alexandre Benedetto et al.   CHEMICAL REVIEWS

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip

(2009) Cintia Roodveldt et al.   EMBO JOURNAL

A Pathogenesis Assay UsingSaccharomycescerevisiaeandCaenorhabditiselegansReveals Novel Roles for Yeast AP-1, Yap1, and Host Dual Oxidase BLI-3 in Fungal Pathogenesis

(2009) Charu Jain et al.   EUKARYOTIC CELL

Reserpine ameliorates Aβ toxicity in the Alzheimer’s disease model in Caenorhabditis elegans

(2009) Upasna Arya et al.   EXPERIMENTAL GERONTOLOGY

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease

(2009) Raja Settivari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditits elegansLRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth

(2009) Julia Sämann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Extracellular Matrix Cross-linking Activity of the Peroxidase MLT-7 and the Dual Oxidase BLI-3 Is Critical for Post-embryonic Viability inCaenorhabditis elegans

(2009) Melanie C. Thein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

(2009) Alicia N Minniti et al.   Molecular Neurodegeneration

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

(2009) Qingmin Ruan et al.   NEUROBIOLOGY OF DISEASE

Metal Ion Physiopathology in Neurodegenerative Disorders

(2009) Silvia Bolognin et al.   NEUROMOLECULAR MEDICINE

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

(2009) Catherine Au et al.   PLoS One

Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration

(2009) Julie A. Moreno et al.   TOXICOLOGICAL SCIENCES

Characterization of the effects of methylmercury on Caenorhabditis elegans

(2009) Kirsten J. Helmcke et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetics of Alzheimer's disease: recent advances

(2009) Dimitrios Avramopoulos   Genome Medicine

Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease

(2008) C. Patterson et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans

(2008) Ryusuke Niwa et al.   DEVELOPMENTAL BIOLOGY

Use of non-mammalian alternative models for neurotoxicological study

(2008) Randall T. Peterson et al.   NEUROTOXICOLOGY

Manganese transport in eukaryotes: The role of DMT1

(2008) Catherine Au et al.   NEUROTOXICOLOGY

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

(2005) Alessandra Gaeta et al.   BRITISH JOURNAL OF PHARMACOLOGY