Review
Biochemistry & Molecular Biology
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
Summary: Randomized controlled trials have shown that reducing LDL-C with statins significantly decreases the risk of developing cardiovascular disease (CVD). However, a considerable number of patients still have residual CVD risk despite statin therapy, particularly in the high-dose statin arms. Elevated TG levels, reduced HDL-C, obesity/insulin resistance, and diabetes are important metabolic factors associated with statin residual CVD risk. Lipoprotein (a), remnant lipoproteins, MDA-LDL, and Sd-LDL play key roles in atherosclerosis and could provide new targets for reducing CVD events in patients receiving statins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joyce Whittington, Anthony Holland
Summary: This article reviews the phenotype and genotype of Prader-Willi syndrome and proposes two possible paths from phenotype to genotype. It also suggests research that can strengthen the evidence for either of these hypotheses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Anne Langsted, Borge G. Nordestgaard, Pia R. Kamstrup
Summary: In a large cohort study, low levels of lipoprotein(a) and corresponding LPA genotypes were found to be associated with lower risk of diseases related to the circulatory system, but not with cancer or infectious diseases. This suggests that lowering lipoprotein(a) to low levels may not increase the risk of cancer or infections.
EUROPEAN HEART JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Jennifer Halma, Henry C. Lin
Summary: Alagille syndrome (ALGS) is a genetic disorder caused by mutations in the Notch signaling pathway genes, resulting in a wide range of clinical features involving multiple organ systems. Despite well-defined genetic mutations, there is significant variability in the clinical phenotypes among individuals with the same mutation.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Health Care Sciences & Services
Beatrice Lioy, Richard James Webb, Farzad Amirabdollahian
Summary: Metabolic syndrome (MetS) is a condition caused by a combination of cardiometabolic risk factors. The diagnostic criteria for MetS are varied, and there is no universal tool to detect it. This study reviewed and summarized observational data on the association between the atherogenic index of plasma (AIP) and cardiometabolic risk factors, finding associations with waist circumference, triglycerides, insulin resistance, and high-density lipoprotein cholesterol, but uncertain association with blood pressure.
Article
Multidisciplinary Sciences
Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem
Summary: The CPIC recently revised their recommendations for the translation of CYP2D6 genotype to phenotype, with changes impacting phenotype grouping and the activity score calculation for CYP2D6*10 allele. This study evaluated the impact of these changes on the relationship between CYP2D6 genotype and risperidone measures in an Asian population, demonstrating that the revised method improved translation accuracy. Additionally, the study found that genotype-phenotype translation may be substrate-dependent, as subjects with an activity score of 1 for CYP2D6 were phenotypically normal for risperidone metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Akemi Kakino, Yoshiko Fujita, Liang-Yin Ke, Hua-Chen Chan, Ming-Hsien Tsai, Chia-Yen Dai, Chu-Huang Chen, Tatsuya Sawamura
Summary: Adiponectin has the ability to bind to and deactivate atherogenic LDL, thereby reducing its atherogenic effects by inhibiting LDL receptor endocytosis and cellular signaling pathways. This finding provides new insights into the antiatherogenic mechanisms of adiponectin.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jesus F. Garcia-Gavilan, Margery A. Connelly, Nancy Babio, Christos S. Matzoros, Emilio Ros, Jordi Salas-Salvado
Summary: Increasing consumption of nuts is associated with a shift towards a less atherogenic pattern of lipoprotein subfraction profile determined by NMR, as well as lower concentrations of branched-chain amino acids and decreased insulin resistance in older individuals at high cardiovascular risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Geriatrics & Gerontology
Zengyao Tang, Mihnea-Alexandru Gaman, Kousalya Prabahar, HanYing Mei
Summary: The meta-analysis of randomized controlled trials shows that the treatment of 178-estradiol plus norethisterone acetate can significantly reduce the concentrations of lipoprotein (a) and apolipoprotein B in postmenopausal women.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaodan Zheng, Xin Zhang, Yong Han, Haofei Hu, Changchun Cao
Summary: This retrospective cohort study found a positive and non-linear association between AIP and the risk of prediabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Biology
Lejun Gong, Dagui Gao, Xingxing Zhang, Shiqi Chen, Jiaqi Qian
Summary: This study attempted to explore the relationship between genotype and phenotype of pancreatitis from a computational perspective. By mining biomedical literature, 6152 genes and 76,753 pairs of genotype and phenotype were extracted. An improved normalized point-wise mutual information (REL-NPMI) model was proposed to optimize gene-phenotype relations, resulting in 12,562 gene-phenotype pairs that may be related to pancreatitis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Nouf Aljawini, Lateefa O. Aldakhil, Syed Shahid Habib
Summary: Lipoprotein(a) levels in Saudi women, which is an inherent CVD risk biomarker, are relatively unexplored. This study examined the effect of age and menopause on Lp(a) levels and explored the correlation between adiposity and cardiometabolic risk factors with Lp(a) in Saudi women. The findings suggest that Lp(a) levels increase with age, especially after menopause, and are positively associated with age and cholesterol while negatively associated with % FFM.
Article
Medicine, Research & Experimental
Shiyue Wang, Li Zha, Jian Chen, Dongjie Du, Danyang Liu, Ming Zhong, Rongfang Shang, Dongxue Sun, Chang Sun, Enze Jin
Summary: This study found a causal relationship between lipoprotein(a) (Lp(a)) and coronary heart disease, aortic aneurysm, and large artery atherosclerosis stroke. However, no causal association was found with atrial fibrillation, heart failure, ischemic stroke, small vessel stroke, lacunar stroke, secondary hypertension, or pulmonary embolism.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Te-Cheng Yueh, Yun-Chi Wang, Yu-Ting Chin, Yi-Chih Hung, Mei-Chin Mong, Ya-Chen Yang, Jen-Sheng Pei, Jian Gu, Chia-Wen Tsai, Da-Tian Bau, Wen-Shin Chang
Summary: This study aimed to investigate the association of mir146a and mir196a-2 genotypes with colorectal cancer (CRC) risk. PCR-RFLP was used to determine the genotypes in 362 CRC patients and 362 controls. The CC genotype of mir196a-2 rs11614913 was associated with a 2.04-fold increased risk of CRC, and carriers of the CT + CC genotypes also had a significant association with CRC risk. No association was found regarding mir146a rs2910164.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jia-Yong Li, Wen-Jun Xu, Zhe Zhou, Ru-lin Zhang, Ting Sun, Hao Xu, Jun Wu
Summary: The study suggested that the AL-c/HDL-c ratio could be a better predictive indicator than RLP-c alone in predicting risk of ST-segment elevation myocardial infarction (STEMI). This ratio was found to be significantly increased in STEMI patients compared to healthy adults, and it showed better prognostic value for both male and female patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Kyoungmi Kim, Lars Berglund
Article
Endocrinology & Metabolism
Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Adnan Abbuthalha, Parneet Kaur, Jasmeen Visla, Sidika Karakas, Lars Berglund
CLINICAL ENDOCRINOLOGY
(2016)
Article
Medicine, Research & Experimental
Sarah B. Garrett, Barbara A. Koenig, Arleen Brown, Jen R. Hult, Elizabeth A. Boyd, Sarah Dry, Daniel Dohan
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2015)
Review
Biochemistry & Molecular Biology
Byambaa Enkhmaa, Erdembileg Anuurad, Lars Berglund
JOURNAL OF LIPID RESEARCH
(2016)
Article
Veterinary Sciences
Byambaa Enkhmaa, Adnan Abbuthalha, Erdembileg Anuurad, Wei Zhang, Alice F. Tarantal, Lars Berglund
JOURNAL OF MEDICAL PRIMATOLOGY
(2015)
Article
Biochemical Research Methods
Sridevi Krishnan, Jincui Huang, Hyeyoung Lee, Andres Guerrero, Lars Berglund, Erdembileg Anuurad, Carlito B. Lebrilla, Angela M. Zivkovic
JOURNAL OF PROTEOME RESEARCH
(2015)
Editorial Material
Medical Laboratory Technology
Byambaa Enkhmaa, Erdembileg Anuurad, Lars Berglund
TRANSLATIONAL RESEARCH
(2015)
Review
Peripheral Vascular Disease
Prasanth Surampudi, Byambaa Enkhmaa, Erdembileg Anuurad, Lars Berglund
CURRENT ATHEROSCLEROSIS REPORTS
(2016)
Article
Endocrinology & Metabolism
Margaret R. Diffenderfer, Stefania Lamon-Fava, Santica M. Marcovina, P. Hugh R. Barrett, Julian Lel, Gregory G. Dolnikowski, Lars Berglund, Ernst J. Schaefer
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Editorial Material
Medical Laboratory Technology
Byambaa Enkhmaa, Erdembileg Anuurad, Lars Berglund
TRANSLATIONAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Anuurad Erdembileg, Annie Mirsoian, Byambaa Enkhmaa, Wei Zhang, Laurel A. Beckett, William J. Murphy, Lars F. Berglund
Article
Health Care Sciences & Services
Heather Young, Sheridan Miyamoto, Deborah Ward, Madan Dharmar, Yajarayma Tang-Feldman, Lars Berglund
TELEMEDICINE AND E-HEALTH
(2014)
Editorial Material
Medicine, General & Internal
Byambaa Enkhmaa, Lars Berglund
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Betty P. Guo, Julie Rainwater, Stacey Neves, Erdembileg Anuurad, Ted Wun, Lars Berglund
Summary: By establishing a K scholar resource platform and utilizing CTSC research resources, UC Davis has provided early career investigators with a high rate of NIH funding success.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Hematology
Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Chin-Shang Li, Robert Kaplan, Jason Lazar, Dan Merenstein, Roksana Karim, Brad Aouizerat, Mardge Cohen, Kenneth Butler, Savita Pahwa, Igho Ofotokun, Adaora A. Adimora, Elizabeth Golub, Lars Berglund
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)