Vascular dysfunction as a target for adjuvant therapy in cerebral malaria

Dimethylarginines: Endogenous Inhibitors of Nitric Oxide Synthesis in Children With Falciparum Malaria

(2014) Joe Brice Weinberg et al.   JOURNAL OF INFECTIOUS DISEASES

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria

(2014) Wesley Solomon et al.   Journal of Neuroinflammation

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

(2014) Lena Serghides et al.   PLoS Pathogens

MRI Findings in a Cohort of Brain Injured Survivors of Pediatric Cerebral Malaria

(2013) Sam D. Kampondeni et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

(2013) Pamela Orjuela-Sánchez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

(2013) C. A. Moxon et al.   BLOOD

Potential Serological Biomarkers of Cerebral Malaria

(2013) Naomi W. Lucchi et al.   DISEASE MARKERS

Nitric oxide scavenging by red cell microparticles

(2013) Chen Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Roles for C5a and C5aR but Not C5L2 in the Pathogenesis of Human and Experimental Cerebral Malaria

(2013) Hani Kim et al.   INFECTION AND IMMUNITY

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1

(2013) Alan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lethal Malaria: Marchiafava and Bignami Were Right

(2013) N. J. White et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children

(2013) Christopher A. Moxon et al.   JOURNAL OF INFECTIOUS DISEASES

A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria

(2013) Panote Prapansilp et al.   MALARIA JOURNAL

Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

(2013) Yuri C Martins et al.   MALARIA JOURNAL

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Expression of the Domain Cassette 8 Plasmodium falciparum Erythrocyte Membrane Protein 1 Is Associated with Cerebral Malaria in Benin

(2013) Gwladys I. Bertin et al.   PLoS One

Cerebral tissue oxygenation impairment during experimental cerebral malaria

(2013) Pedro Cabrales et al.   Virulence

Acute Brain MRI Findings in 120 Malawian Children with Cerebral Malaria: New Insights into an Ancient Disease

(2012) M.J. Potchen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Angiopoietins in angiogenesis

(2012) Ernesta Fagiani et al.   CANCER LETTERS

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

(2012) Andrea L. Conroy et al.   CRITICAL CARE MEDICINE

Cerebral malaria pathogenesis: revisiting parasite and host contributions

(2012) Georges Emile Raymond Grau et al.   Future Microbiology

S-nitrosoglutathione Prevents Experimental Cerebral Malaria

(2012) Graziela M. Zanini et al.   Journal of Neuroimmune Pharmacology

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Endothelin and endothelin receptors in the renal and cardiovascular systems

(2012) Nicolas Vignon-Zellweger et al.   LIFE SCIENCES

Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve?

(2012) Donald E. Kohan et al.   LIFE SCIENCES

The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative

(2012) Minxian Dai et al.   LIFE SCIENCES

Host immune response in returning travellers infected with malaria

(2012) Gregory MacMullin et al.   MALARIA JOURNAL

A Chronic Scheme of Cranial Window Preparation to Study Pial Vascular Reactivity in Murine Cerebral Malaria

(2012) Peng Kai Ong et al.   MICROCIRCULATION

Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA

(2012) Yuri C. Martins et al.   PLoS One

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

(2012) T. Lavstsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral malaria: What is known and what is on research

(2012) F. Gay et al.   REVUE NEUROLOGIQUE

Serum angiopoietin-2 level as a predictor of tumor invasiveness in patients with hepatocellular carcinoma

(2012) Antonio Diaz-Sanchez et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Cerebral malaria

(2012) Laurent Rénia et al.   Virulence

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

Artemether and Artesunate Show the Highest Efficacies in Rescuing Mice with Late-Stage Cerebral Malaria and Rapidly Decrease Leukocyte Accumulation in the Brain

(2011) L. Clemmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of the endothelin axis and its antagonists in the treatment of cancer

(2011) A Bagnato et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiopoietins as prognostic biomarkers and effector molecules in severe sepsis

(2011) Enitan D. Carrol   CRITICAL CARE MEDICINE

Multiple roles of angiopoietins in atherogenesis

(2011) Asif Ahmed et al.   CURRENT OPINION IN LIPIDOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria

(2011) M. J. Ponsford et al.   JOURNAL OF INFECTIOUS DISEASES

Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology

(2011) Pedro Cabrales et al.   JOURNAL OF INFECTIOUS DISEASES

Brain endothelial barrier passage by monocytes is controlled by the endothelin system

(2011) Arie Reijerkerk et al.   JOURNAL OF NEUROCHEMISTRY

Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice

(2011) Graziela M Zanini et al.   Journal of Neuroinflammation

The relevance of non-human primate and rodent malaria models for humans

(2011) Jean Langhorne et al.   MALARIA JOURNAL

Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India

(2011) Vidhan Jain et al.   MALARIA JOURNAL

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(2011) Constance Finney et al.   MOLECULAR MEDICINE

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria

(2011) Lena Serghides et al.   PLoS One

Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial

(2011) Michael Hawkes et al.   Trials

Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction, and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine

(2010) Pedro Cabrales et al.   AMERICAN JOURNAL OF PATHOLOGY

Dysregulation of l-arginine metabolism and bioavailability associated to free plasma heme

(2010) F. Omodeo-Salè et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

(2010) F. G. Baptista et al.   INFECTION AND IMMUNITY

The Lipid Moiety of Haemozoin (Malaria Pigment) andP. falciparumParasitised Red Blood Cells Bind Synthetic and Native Endothelin-1

(2010) Nicoletta Basilico et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria

(2010) F. H. Amante et al.   JOURNAL OF IMMUNOLOGY

Greater Endothelial Activation, Weibel‐Palade Body Release and Host Inflammatory Response toPlasmodium vivax,Compared withPlasmodium falciparum: A Prospective Study in Papua, Indonesia

(2010) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats

(2010) J.J. Li et al.   NEUROSCIENCE

Dysregulation of Angiopoietins Is Associated with Placental Malaria and Low Birth Weight

(2010) Karlee L. Silver et al.   PLoS One

Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study

(2010) Andrea L. Conroy et al.   PLoS One

Cerebral malaria: human versus mouse studies

(2010) Mary M. Stevenson et al.   TRENDS IN PARASITOLOGY

Neuropathogenesis of human and murine malaria

(2010) Eleanor M. Riley et al.   TRENDS IN PARASITOLOGY

Murine cerebral malaria: the whole story

(2010) Nicholas H. Hunt et al.   TRENDS IN PARASITOLOGY

Cerebral malaria: in praise of epistemes

(2010) Laurent Rénia et al.   TRENDS IN PARASITOLOGY

Murine cerebral malaria: how far from human cerebral malaria?

(2010) Leonardo J.M. Carvalho   TRENDS IN PARASITOLOGY

Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?

(2010) Blandine Franke-Fayard et al.   PLoS Pathogens

Cerebral Malaria: A New Way Forward with Magnetic Resonance Imaging (MRI)

(2009) Sornchai Looareesuwan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Cerebrovascular Endothelin Receptor Upregulation in Cerebral Ischemia

(2009) Lars Edvinsson   Current Vascular Pharmacology

Characterization of cerebral malaria in the outbred Swiss Webster mouse infected byPlasmodium bergheiANKA

(2009) Yuri Chaves Martins et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Relationship of Cell‐Free Hemoglobin to Impaired Endothelial Nitric Oxide Bioavailability and Perfusion in Severe Falciparum Malaria

(2009) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria

(2009) Andrea L Conroy et al.   MALARIA JOURNAL

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

(2009) J. BRIAN de SOUZA et al.   PARASITOLOGY

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

(2009) Fiona E. Lovegrove et al.   PLoS One

The murine cerebral malaria phenomenon

(2009) Nicholas J. White et al.   TRENDS IN PARASITOLOGY

Antigenic Variation in Plasmodium falciparum

(2008) Artur Scherf et al.   Annual Review of Microbiology

Pharmacokinetics of L-Arginine in Adults with Moderately Severe Malaria

(2008) T. W. Yeo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endothelin Receptor Dimers Evaluated by FRET, Ligand Binding, and Calcium Mobilization

(2008) Nathan J. Evans et al.   BIOPHYSICAL JOURNAL

Nitric Oxide and Arginine Dysregulation: A Novel Pathway to Pulmonary Hypertension in Hemolytic Disorders

(2008) Claudia Morris et al.   CURRENT MOLECULAR MEDICINE

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations

(2008) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

Perfusion Abnormalities in Children with Cerebral Malaria and Malarial Retinopathy

(2008) Nicholas A. V. Beare et al.   JOURNAL OF INFECTIOUS DISEASES

Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria

(2008) Anelia Dietmann et al.   MALARIA JOURNAL

Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis

(2008) Christopher S. Milner et al.   MICROVASCULAR RESEARCH

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

(2008) C. C. John et al.   PEDIATRICS

Regulation of glial inflammatory mediators synthesis: Possible role of endothelins

(2008) Talia Filipovich et al.   PEPTIDES

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

(2008) T. W. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA