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Resistance to BRAF Inhibitors: Unraveling Mechanisms and Future Treatment Options

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Resistance to BRAF Inhibition in Melanomas

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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

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Advances in systemic treatment of melanoma

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Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

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Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells

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PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

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MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720

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(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS

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Small molecules and targeted therapies in distant metastatic disease

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Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

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Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

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Improving Melanoma Classification by Integrating Genetic and Morphologic Features

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