Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications

The RP-Mdm2-p53 Pathway and Tumorigenesis

(2015) Paula L. Miliani de Marval et al.   Oncotarget

RPL41, a Small Ribosomal Peptide Deregulated in Tumors, Is Essential for Mitosis and Centrosome Integrity

(2015) Shan Wang et al.   NEOPLASIA

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Replication of Breast Cancer Susceptibility Loci in Whites and African Americans Using a Bayesian Approach

(2013) Katie M. O'Brien et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

(2013) Sladana Bursac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis

(2013) Serges P Tsofack et al.   BMC CANCER

Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer

(2013) A. Khalaileh et al.   CANCER RESEARCH

Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4

(2013) Zhong-Yin Yang et al.   CARCINOGENESIS

Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease

(2013) Jun Lv et al.   CLINICAL SCIENCE

The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression

(2013) Neetu Rohit Kapoor et al.   FEBS LETTERS

Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond–Blackfan anemia

(2013) Michael Landowski et al.   HUMAN GENETICS

Ribosomal Protein S14 Negatively Regulates c-Myc Activity

(2013) Xiang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic ribosome biogenesis at a glance

(2013) E. Thomson et al.   JOURNAL OF CELL SCIENCE

An Extraribosomal Function of Ribosomal Protein L13a in Macrophages Resolves Inflammation

(2013) D. Poddar et al.   JOURNAL OF IMMUNOLOGY

Down-regulation of ribosomal protein L22 in non-small cell lung cancer

(2013) Mingxia Yang et al.   MEDICAL ONCOLOGY

Ribosomal protein S7 regulates arsenite-induced GADD45  expression by attenuating MDM2-mediated GADD45  ubiquitination and degradation

(2013) M. Gao et al.   NUCLEIC ACIDS RESEARCH

Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress

(2013) Dongmei Bai et al.   NUCLEIC ACIDS RESEARCH

The ribosomal protein S26 regulates p53 activity in response to DNA damage

(2013) D Cui et al.   ONCOGENE

Molecular characteristics of a pancreatic adenocarcinoma associated with Shwachman-Diamond syndrome

(2013) Santhosh Dhanraj et al.   PEDIATRIC BLOOD & CANCER

Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting Prognoses

(2013) Chi-Jung Huang et al.   PLoS One

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network

(2013) Lilyn Daftuar et al.   PLoS One

Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia

(2013) A. Bolze et al.   SCIENCE

Multiple Ribosomal Proteins Are Expressed at High Levels in Developing Zebrafish Endoderm and Are Required for Normal Exocrine Pancreas Development

(2013) Elayne Provost et al.   Zebrafish

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

(2013) Dawn E. Watkins-Chow et al.   PLoS Genetics

Genetics of Ribosomal Proteins: “Curiouser and Curiouser”

(2013) Tamara Terzian et al.   PLoS Genetics

Gene-Environment Interactions for Breast Cancer Risk Among Chinese Women: A Report From the Shanghai Breast Cancer Genetics Study

(2012) H. Li et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine

(2012) Lingyun Wu et al.   ANNALS OF HEMATOLOGY

Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation

(2012) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomal protein S3 localizes on the mitotic spindle and functions as a microtubule associated protein in mitosis

(2012) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomal proteins: Structure, function, and evolution

(2012) A. V. Korobeinikova et al.   BIOCHEMISTRY-MOSCOW

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

(2012) S. Rao et al.   BLOOD

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone

(2012) G. Donati et al.   CANCER RESEARCH

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1levels in a p53-independent manner

(2012) Annapina Russo et al.   CELL CYCLE

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

(2012) S Lee et al.   CELL DEATH AND DIFFERENTIATION

Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation

(2012) Elaine M. Smolock et al.   CIRCULATION

Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development

(2012) E. Provost et al.   DEVELOPMENT

Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice

(2012) D. T. Jones et al.   Disease Models & Mechanisms

Arrested cell proliferation through cysteine protease activity of eukaryotic ribosomal protein S4

(2012) Madasu Yadaiah et al.   FASEB JOURNAL

PEP-1–ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model

(2012) Eun Hee Ahn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Frameshift mutation in p53 regulatorRPL26is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia

(2012) Hanna T. Gazda et al.   HUMAN MUTATION

cDNA Cloning, Overexpression, Purification and Pharmacologic Evaluation for Anticancer Activity of Ribosomal Protein L23A Gene (RPL23A) from the Giant Panda

(2012) Bing Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor Suppressor ARF

(2012) Mu-Shui Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Ribosomal Protein S3 and Antiapoptotic TRAF2 Protein Mediates Radioresistance in Non-small Cell Lung Cancer Cells

(2012) Hee Jung Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion

(2012) Dorothy Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in the ribosomal machinery in cancer and hematologic disorders

(2012) Niraj Shenoy et al.   Journal of Hematology & Oncology

Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

(2012) Seok-Hyung Kim et al.   MODERN PATHOLOGY

Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells

(2012) Chaodong Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet

(2012) C. Treins et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression, purification, and evaluation for anticancer activity of ribosomal protein L31 gene (RPL31) from the giant panda (Ailuropoda melanoleuca)

(2012) Xiu-Lan Su et al.   MOLECULAR BIOLOGY REPORTS

Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression

(2012) Maja M. Janas et al.   MOLECULAR CELL

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

(2012) Lior Golomb et al.   MOLECULAR CELL

Specialized ribosomes: a new frontier in gene regulation and organismal biology

(2012) Shifeng Xue et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation

(2012) Frédéric Lessard et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress

(2012) X Zhou et al.   ONCOGENE

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

(2012) S Wei et al.   ONCOGENE

hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14

(2012) J Zhang et al.   ONCOGENE

Identification of ribosomal protein S25 (RPS25)–MDM2–p53 regulatory feedback loop

(2012) X Zhang et al.   ONCOGENE

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure and Function of the Eukaryotic Ribosome

(2012) D. N. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro

(2012) H Moniz et al.   Cell Death & Disease

p53 -Dependent and -Independent Nucleolar Stress Responses

(2012) Karl Holmberg Olausson et al.   Cells

Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder

(2011) A. Chiocchetti et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Role of S6K1 in regulation of SREBP1c expression in the liver

(2011) Shuying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CDK11p46 and RPS8 associate with each other and suppress translation in a synergistic manner

(2011) Yuqing Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomal protein S3 is stabilized by sumoylation

(2011) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

(2011) Ruomin Di et al.   BIOCHEMICAL JOURNAL

Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome

(2011) K. A. McGowan et al.   BLOOD

Ribosomal protein gene deletions in Diamond-Blackfan anemia

(2011) J. E. Farrar et al.   BLOOD

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia

(2011) P. Jaako et al.   BLOOD

Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway

(2011) Chien-Ting Wu et al.   CARCINOGENESIS

Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

(2011) Nadya Kondrashov et al.   CELL

Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

(2011) Carlos I. Michel et al.   Cell Metabolism

A Novel Interaction Between Interferon-Inducible Protein p56 and Ribosomal Protein L15 in Gastric Cancer Cells

(2011) Yu-An Hsu et al.   DNA AND CELL BIOLOGY

Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency inDrosophila melanogaster

(2011) Michelle E. Casad et al.   GENETICS

Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish

(2011) Juan Duan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: The role of apoptosis induction of gastric cancer cells

(2011) Zhong-Yin Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Interplay between Ribosomal Protein S27a and MDM2 Protein in p53 Activation in Response to Ribosomal Stress

(2011) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation

(2011) Qi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Ribosomal Protein S6 Phosphorylation by Casein Kinase 1 and Protein Phosphatase 1

(2011) John A. Hutchinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleolus directly regulates p53 export and degradation

(2011) Mark T. Boyd et al.   JOURNAL OF CELL BIOLOGY

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

(2011) Giulio Donati et al.   JOURNAL OF CELL SCIENCE

Developmental Arrest of T Cells in Rpl22-Deficient Mice Is Dependent upon Multiple p53 Effectors

(2011) J. E. Stadanlick et al.   JOURNAL OF IMMUNOLOGY

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

(2011) Aiyuan Wang et al.   JOURNAL OF PATHOLOGY

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

(2011) Tamara Terzian et al.   JOURNAL OF PATHOLOGY

Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress

(2011) K. B. Challagundla et al.   MOLECULAR AND CELLULAR BIOLOGY

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

(2011) Muyang Li et al.   MOLECULAR CELL

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner

(2011) B Mahata et al.   ONCOGENE

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

(2011) G Donati et al.   ONCOGENE

LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

(2011) C E King et al.   ONCOGENE

RPL36 as a prognostic marker in hepatocellular carcinoma

(2011) Myeong Jun Song et al.   PATHOLOGY INTERNATIONAL

siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer

(2011) Alix Bee et al.   PLoS One

Downregulation of RPL6 by siRNA Inhibits Proliferation and Cell Cycle Progression of Human Gastric Cancer Cell Lines

(2011) Qiong Wu et al.   PLoS One

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

(2011) Christina E. Drakou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

(2011) S. Klinge et al.   SCIENCE

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

Guarding the ‘translation apparatus’: defective ribosome biogenesis and the p53 signaling pathway

(2011) Anirban Chakraborty et al.   Wiley Interdisciplinary Reviews-RNA

Eukaryotic 5S rRNA biogenesis

(2011) Martin Ciganda et al.   Wiley Interdisciplinary Reviews-RNA

Ribosomal Protein Genes RPS10 and RPS26 Are Commonly Mutated in Diamond-Blackfan Anemia

(2010) Leana Doherty et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells

(2010) Yawen Gou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome

(2010) A. Pellagatti et al.   BLOOD

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

(2010) S. Dutt et al.   BLOOD

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Ribosomal dysfunction and inherited marrow failure

(2010) Karthik A. Ganapathi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects

(2010) Nadia Danilova et al.   BRITISH JOURNAL OF HAEMATOLOGY

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

New insights into 5q- syndrome as a ribosomopathy

(2010) Jillian L. Barlow et al.   CELL CYCLE

Nucleostemin

(2010) Dorothy Lo et al.   CELL CYCLE

The RP-p53-Mdm2 pathway

(2010) Rebecca A. Frum et al.   CELL CYCLE

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway

(2010) Susana Llanos et al.   CELL CYCLE

The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition

(2010) Anna Malekkou et al.   FEBS LETTERS

Ribosomal 18 S RNA Processing by the IGF-I-responsive WDR3 Protein Is Integrated with p53 Function in Cancer Cell Proliferation

(2010) Mary McMahon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway

(2010) Michael Hölzel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

(2010) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein S3, a New Substrate of Akt, Serves as a Signal Mediator between Neuronal Apoptosis and DNA Repair

(2010) Sang Bae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein L11 Associates with c-Myc at 5 S rRNA and tRNA Genes and Regulates Their Expression

(2010) Mu-Shui Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits

(2010) Marie-Françoise O’Donohue et al.   JOURNAL OF CELL BIOLOGY

Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality

(2010) Yoshihiro Handa et al.   JOURNAL OF MOLECULAR BIOLOGY

When ribosomes go bad: diseases of ribosome biogenesis

(2010) Emily F. Freed et al.   Molecular BioSystems

Defining the Pathway of Cytoplasmic Maturation of the 60S Ribosomal Subunit

(2010) Kai-Yin Lo et al.   MOLECULAR CELL

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

(2010) Frédéric Lessard et al.   MOLECULAR CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53–MDM2 loop

(2010) Weishi Yu et al.   NUCLEIC ACIDS RESEARCH

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

(2010) Y. Zhang et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5′ terminal oligopyrimidine tract

(2010) P R Hagner et al.   ONCOGENE

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator

(2010) X Xiong et al.   ONCOGENE

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation

(2010) Mikael S. Lindström et al.   PLoS One

Dystroglycan and Mitochondrial Ribosomal Protein L34 Regulate Differentiation in the Drosophila Eye

(2010) Yougen Zhan et al.   PLoS One

Depletion of ribosomal protein L8 impairs Drosophila development and is associated with apoptosis

(2010) HongYan Li et al.   Science China-Life Sciences

Maturation of eukaryotic ribosomes: acquisition of functionality

(2010) Vikram Govind Panse et al.   TRENDS IN BIOCHEMICAL SCIENCES

An investigation of ribosomal protein L10 gene in autism spectrum disorders

(2009) Xiaohong Gong et al.   BMC Medical Genetics

Bone marrow cells from patients with Shwachman-Diamond syndrome abnormally express genes involved in ribosome biogenesis and RNA processing

(2009) Piya Rujkijyanont et al.   BRITISH JOURNAL OF HAEMATOLOGY

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

(2009) Sridevi Yadavilli et al.   DNA REPAIR

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

Rplp1 bypasses replicative senescence and contributes to transformation

(2009) A. Artero-Castro et al.   EXPERIMENTAL CELL RESEARCH

Synthesis and function of ribosomal proteins - fading models and new perspectives

(2009) Sara Caldarola et al.   FEBS Journal

Shwachman-Diamond Syndrome: A Review of the Clinical Presentation, Molecular Pathogenesis, Diagnosis, and Treatment

(2009) Lauri Burroughs et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia

(2009) Radek Cmejla et al.   HUMAN MUTATION

Phosphorylation Status of Nuclear Ribosomal Protein S3 Is Reciprocally Regulated by Protein Kinase Cδ and Protein Phosphatase 2A

(2009) Tae-Sung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function

(2009) Ana-Maria Filip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of ribosomal protein L7A in human osteosarcoma

(2009) Shui-er Zheng et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1

(2009) Xueyan Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RPS2: a novel therapeutic target in prostate cancer

(2009) Min Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival

(2009) M. Barkic et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?

(2009) Mark Wade et al.   MOLECULAR CANCER RESEARCH

How Common Are Extraribosomal Functions of Ribosomal Proteins?

(2009) Jonathan R. Warner et al.   MOLECULAR CELL

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

(2009) Yan Zhu et al.   MOLECULAR CELL

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response

(2009) Anirban Chakraborty et al.   PLoS One

Mice Deficient in Ribosomal Protein S6 Phosphorylation Suffer from Muscle Weakness that Reflects a Growth Defect and Energy Deficit

(2009) Igor Ruvinsky et al.   PLoS One

MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties

(2009) E. Kashuba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

(2008) Hanna T. Gazda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Emerging functions of ribosomal proteins in gene-specific transcription and translation

(2008) Mikael S. Lindström   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex

(2008) Seeyoung Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PKCδ-dependent functional switch of rpS3 between translation and DNA repair

(2008) Tae-Sung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

(2008) J. E. Farrar et al.   BLOOD

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

(2008) N. Danilova et al.   BLOOD

Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function

(2008) Maria E. Castro et al.   CARCINOGENESIS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Elevated Phospho-S6 Expression Is Associated with Metastasis in Adenocarcinoma of the Lung

(2008) J. M. McDonald et al.   CLINICAL CANCER RESEARCH

Targeting the MDM2-p53 Interaction for Cancer Therapy

(2008) S. Shangary et al.   CLINICAL CANCER RESEARCH

Ribosomal proteins are targets for the NEDD8 pathway

(2008) Dimitris P Xirodimas et al.   EMBO REPORTS

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

(2008) Markus Haindl et al.   EMBO REPORTS

Gene therapy of Diamond Blackfan anemia CD34+ cells leads to improved erythroid development and engraftment following transplantation

(2008) Johan Flygare et al.   EXPERIMENTAL HEMATOLOGY

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

(2008) Tamayo Uechi et al.   HUMAN MOLECULAR GENETICS

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

(2008) V. Choesmel et al.   HUMAN MOLECULAR GENETICS

Treacher Collins syndrome: Unmasking the role of Tcof1/treacle

(2008) Daisuke Sakai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11

(2008) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein S9 Is a Novel B23/NPM-binding Protein Required for Normal Cell Proliferation

(2008) Mikael S. Lindström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer

(2008) C.-J Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation

(2008) Christina N. Matragkou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

(2008) Mu-Shui Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ischemia-induced ribosomal protein S3 expressional changes and the neuroprotective effect against experimental cerebral ischemic damage

(2008) In Koo Hwang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice

(2008) Daniel S. Oristian et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Suppression of putative tumour suppressor geneGLTSCR2expression in human glioblastomas

(2008) Y-J Kim et al.   JOURNAL OF PATHOLOGY

Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

(2008) M.-S. Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating Inflammatory Gene Expression

(2008) Rupak Mukhopadhyay et al.   MOLECULAR CELL

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth

(2008) Michael Wanzel et al.   NATURE CELL BIOLOGY

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

(2008) Natalie C Jones et al.   NATURE MEDICINE

Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling

(2008) Y-J Jeon et al.   ONCOGENE

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

(2008) H F Horn et al.   ONCOGENE

Akt phosphorylation of La regulates specific mRNA translation in glial progenitors

(2008) F Brenet et al.   ONCOGENE

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

(2008) A. W. MacInnes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA