DNA-Binding Small Molecules as Inhibitors of Transcription Factors

Determination of the drug–DNA binding modes using fluorescence-based assays

(2012) Alicia K. Williams et al.   ANALYTICAL BIOCHEMISTRY

Specific Blocking of CREB/DNA Binding by Cyclometalated Platinum(II) Complexes

(2011) Ping Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole–Imidazole Polyamide

(2011) Yi Zhang et al.   BIOCHEMISTRY

DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma

(2011) G Singhal et al.   CANCER GENE THERAPY

In vitro DNA-binding profile of transcription factors: methods and new insights

(2011) Jinke Wang et al.   JOURNAL OF ENDOCRINOLOGY

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Metastatic bone disease: Role of transcription factors and future targets

(2010) Jitesh Pratap et al.   BONE

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

The Ups and Downs of Transcription Factors in Melanoma

(2010) A. Santiago-Walker et al.   JNCI-Journal of the National Cancer Institute

Transcriptional inhibition of progressive renal disease by gene silencing pyrrole–imidazole polyamide targeting of the transforming growth factor-β1 promoter

(2010) Hiroyuki Matsuda et al.   KIDNEY INTERNATIONAL

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

(2009) K. M. Sakamoto et al.   CLINICAL CANCER RESEARCH

Drug Effects Viewed from a Signal Transduction Network Perspective

(2009) Anton F. Fliri et al.   JOURNAL OF MEDICINAL CHEMISTRY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Allosteric modulation of DNA by small molecules

(2009) D. M. Chenoweth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The androgen receptor in hormone-refractory prostate cancer

(2008) Hai-Lei Mao et al.   ASIAN JOURNAL OF ANDROLOGY

Targeting DNA with triplex-forming oligonucleotides to modify gene sequence

(2008) Philippe Simon et al.   BIOCHIMIE

Quantitating the concentration of Py-Im polyamide–fluorescein conjugates in live cells

(2008) Carey F. Hsu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Properties and Toxicity of Chromium(III) Nutritional Supplements

(2008) Aviva Levina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY

Nuclear Receptors and Inflammatory Diseases

(2008) Kun Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery After Injury

(2008) En-Hui Yao et al.   HYPERTENSION

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

(2008) M. Kotecha et al.   MOLECULAR CANCER THERAPEUTICS

Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication

(2008) Paul Peixoto et al.   NUCLEIC ACIDS RESEARCH

POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis

(2008) Anthony L. Cook et al.   Pigment Cell & Melanoma Research

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY

Chromium(III) complexes inhibit transcription factors binding to DNA and associated gene expression

(2008) Natesan S. Raja et al.   TOXICOLOGY