Article
Multidisciplinary Sciences
Minyoung Oh, Narae Lee, Chanwoo Kim, Hye Joo Son, Changhwan Sung, Seung Jun Oh, Sang Ju Lee, Sun Ju Chung, Chong Sik Lee, Jae Seung Kim
Summary: Dual phase F-18-FP-CIT PET and F-18-FDG PET can aid in the differential diagnosis of degenerative parkinsonism and other parkinsonian disorders, showing a high concordance rate with clinical diagnosis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Palermo, Sara Giannoni, Gabriele Bellini, Gabriele Siciliano, Roberto Ceravolo
Summary: This review highlights the importance of dopamine transporter imaging in clinical research of PD, discussing its role as a biomarker in diagnosis, preclinical, and predictive aspects. The article emphasizes the use of dopamine transporter imaging in assessing PD pathology, as well as recent studies questioning its correlation with nigral cell or axon counts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanyi Fang, Samantha Rossano, Xingxing Wang, Nabeel Nabulsi, Brian Kelley, Krista Fowles, Jim Ropchan, Stephen M. Strittmatter, Richard E. Carson, Yiyun Huang
Summary: The study investigated the potential use of PET imaging with SERT radioligand [C-11]AFM as a biomarker for axon damage after spinal cord injury (SCI). The results showed that the [C-11]AFM PET imaging method could effectively visualize the rodent spinal cord and detect SERT changes in SCI rodent models. However, there was limited specific binding signal for [C-11]AFM in the human spinal cord, indicating the need for a tracer with higher affinity and lower non-specific binding signal for imaging the spinal cord in humans and assessing axonal status in SCI patients.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paul Cumming, Milan Scheidegger, Dario Dornbierer, Mikael Palner, Boris B. Quednow, Chantal Martin-Soelch
Summary: Hallucinogens are a group of compounds that can evoke intense visual and emotional experiences, leading to a renewed interest in research, particularly in their psychotherapeutic potential. Molecular imaging techniques can depict the uptake and binding distribution of these compounds in the brain, but there is still abundant room for basic imaging research in this area.
Review
Biochemistry & Molecular Biology
George Crisan, Nastasia Sanda Moldovean-Cioroianu, Diana-Gabriela Timaru, Gabriel Andries, Calin Cainap, Vasile Chis
Summary: Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are imaging techniques that use radioactive tracers. PET is mainly used for measuring metabolic processes, blood flow, and chemical composition, while SPECT is used for diagnosing conditions such as strokes, bone diseases, and infections. This article provides a systematic review of the scientific literature on PET/SPECT radiotracers and gives an overview of the research conducted in the past decade, with a focus on novel radiopharmaceuticals for medical imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Article
Rehabilitation
Juliana M. P. Toldo, Michelly Arjona, Guilherme C. Campos Neto, Taise Vitor, Solange Amorim Nogueira, Edson Amaro, Roberta A. Saba, Sonia M. C. A. Silva, Henrique B. Ferraz, Andre C. Felicio
Summary: The study demonstrated that a virtual rehabilitation protocol for patients with Parkinson's disease led to an increase in dopamine transporters in the putamen contralateral to the clinically most affected body side, as well as significant improvement in motor symptoms and quality of life.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Biochemistry & Molecular Biology
Leon Jesus German-Ponciano, Gilberto Uriel Rosas-Sanchez, Jonathan Cueto-Escobedo, Rafael Fernandez-Demeneghi, Gabriel Guillen-Ruiz, Cesar Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: Depressive disorders are a highly disabling global disease, with increasing incidence in recent decades. Flavonoids hold promise as potential antidepressants, with mechanisms that are not fully understood. Individuals with depression have low levels of serotonin and BDNF, which can be reversed by flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Carsten S. Kramer, Antonia Dimitrakopoulou-Strauss
Summary: Immunotherapy has revolutionized the treatment of certain cancer types, but conventional methods for assessing treatment response pose challenges. This study analyzed published tracers and found that most target PD-L1, PD-1, CTLA-4, and CD8 receptors using antibodies or their fragments. It also identified a lack of innovation in tracer development.
Article
Neurosciences
Jamie van Son, Katy A. van Galen, Anne Marijn Bruijn, Karin E. Koopman, Ruth I. Versteeg, Susanne E. la Fleur, Mireille J. Serlie, Jan Booij
Summary: Food craving is increased in obesity, but the scores for food craving are not significantly related to changes in striatal DAT availability.
Article
Computer Science, Interdisciplinary Applications
Chang-Hoon Choi, Suk-Min Hong, Joerg Felder, Lutz Tellmann, Juergen Scheins, Elena Rota Kops, Christoph Lerche, N. Jon Shah
Summary: Simultaneous MR-PET/-SPECT is a promising technology that combines the advantages of both MRI and PET/SPECT, allowing for sensitive tracer imaging and versatile functional imaging capabilities. The use of a novel gamma-radiation-transparent antenna concept optimizes system performance and image quality for both ultra-high field MRI and the 511 keV transmission scan.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Review
Cell Biology
Andrei Turkin, Oksana Tuchina, Friederike Klempin
Summary: Microglia are resident immune cells in the adult brain that respond to stimuli by activating an acute inflammatory response, involving cytokine release and phagocytosis. Chronic microglia-mediated inflammation in diseases, particularly neurodegenerative disorders, is associated with disease progression. Understanding microglia communication with their environment, release of neurotrophins, and interaction with serotonin is crucial for maintaining neural circuit homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Max Andersson, Amma Tangen, Lars Farde, Sven Bolte, Christer Halldin, Jacqueline Borg, Johan Lundberg
Summary: Adult individuals with Autism Spectrum Disorder (ASD) exhibit lower availability of serotonin transporter (5-HTT) in the brain, which is associated with social cognitive test performance. These findings support the role of serotonin in the neurodevelopment of ASD and underscore the importance of continued investigation of the serotonin system to unravel the biology of ASD.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Kristoffer Johansson, Mats Adler, Ullvi Bave, Carl-Johan Ekman, Johan Lundberg
Summary: This study investigated the effects of different doses of magnetic pulses on MDD patients treated with rTMS, finding that 4000 pulses had the most significant effect in the initial phase of treatment. After 4 weeks, all three treatment groups showed significant improvements in depressive symptoms, with no serious adverse events reported.
Article
Psychiatry
Irma Ahmad, Matilda Sandberg, Ole Brus, Carl Johan Ekman, Asa Hammar, Mikael Landen, Johan Lundberg, Pia Nordanskog, Lars von Knorring, Axel Nordenskjold
Summary: The study found high validity of the diagnoses, treatment dates, and rating scales in the Swedish national quality register for electroconvulsive therapy (Q-ECT) by comparing data from Q-ECT with patient records. The accordance between the two sources was 89% or higher using a strict method of assessment and 95% or higher using a liberal method. Limited use of some rating scales may impact the certainty of the results, but measures can be taken to improve data quality further.
NORDIC JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Johan Lundberg, Thomas Cars, Sven-Ake Loov, Jonas Soderling, Jari Tiihonen, Amy Leval, Anna Gannedahl, Carl Bjorkholm, Mikael Sjalin, Clara Hellner
Summary: In this study, the clinical and societal burden of incident MDD was estimated using healthcare data from different levels in a well-defined healthcare region. The results showed that MDD patients experience significant morbidity, higher healthcare resource utilization, work loss, and increased mortality compared to controls.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Endocrinology & Metabolism
Emma R. Veldman, Andrea Varrone, Katarina Varnas, Marie M. Svedberg, Zsolt Cselenyi, Mikael Tiger, Balazs Gulyas, Christer Halldin, Johan Lundberg
Summary: This study aims to improve PET quantification of 5-HT1B receptor binding in the brainstem by testing and comparing two different VOI delineation methods. Both methods showed improved reliability compared to a conventional manual VOI, and the VOIs created with template data can be automatically applied to future PET studies measuring 5-HT1B receptor binding in the brainstem.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Pontus Plaven-Sigray, Pauliina Ikonen Victorsson, Alexander Santillo, Granville J. Matheson, Maria Lee, Karin Collste, Helena Fatouros-Bergman, Carl M. Sellgren, Sophie Erhardt, Ingrid Agartz, Christer Halldin, Lars Farde, Simon Cervenka
Summary: Pharmacological and genetic evidence suggest a role for the dopamine D2-receptor in schizophrenia pathophysiology. This study used PET imaging to compare D2-R density in thalamus between first-episode psychosis patients and healthy controls, finding lower binding in patients and suggesting a potential disturbance of thalamocortical connectivity. Additionally, diffusion tensor imaging revealed lower fractional anisotropy values in the inferior thalamic radiation in patients compared to controls.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Aurelija Jucaite, Zsolt Cselenyi, William C. Kreisl, Eugenii A. Rabiner, Andrea Varrone, Richard E. Carson, Juha O. Rinne, Alicia Savage, Magnus Schou, Peter Johnstrom, Per Svenningsson, Olivier Rascol, Wassilios G. Meissner, Paolo Barone, Klaus Seppi, Horacio Kaufmann, Gregor K. Wenning, Werner Poewe, Lars Farde
Summary: In this study, PET imaging of TSPO showed significantly increased binding in MSA patients, with machine learning improving sensitivity. Glia imaging may support clinical MSA diagnosis and patient stratification in clinical trials on novel drug therapies.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Patrik Mattsson, Zsolt Cselenyi, Bengt Andree, Jacqueline Borg, Sangram Nag, Christer Halldin, Lars Farde
Summary: This study used positron emission tomography (PET) to examine the binding of the 5-HT1A receptor in mild Alzheimer's disease (AD) patients and elderly controls. The results showed lower receptor binding in AD patients compared to controls, with statistically significant differences in the hippocampus, entorhinal cortex, and amygdala. There was also a significant correlation between hippocampal binding and Disability Assessment for Dementia scores.
Article
Psychiatry
S. Spulber, F. Elberling, J. Svensson, M. Tiger, S. Ceccatelli, J. Lundberg
Summary: This study investigates the correlation between activity patterns and severity of depressive symptoms. Multiple regression models were trained using activity monitoring recordings, and the results suggest that activity patterns are related to the severity of depressive symptoms, indicating that activity recordings may be a useful tool for evaluating patients with major depressive disorder.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Kenneth Dahl, Peter Johnstrom, Anton Forsberg-Moren, Bjorn Gustafsson, Patricia Miranda-Azpiazu, Yaser Khani, Christer Halldin, Lars Farde, Charles S. Elmore, Magnus Schou
Summary: This study reports the preparation and evaluation of two candidate 5-HT1A radioligands in vitro and in vivo. Although one of the radioligands showed high specific binding in human brain tissue, its regional binding potential values in cynomolgus monkey brain were low, suggesting it is not suitable for further investigation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Juha O. Rinne, Aurelija Jucaite, Zsolt Cselenyi, Lars Farde
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Jonas E. Svensson, Mikael Tiger, Pontus Plaven-Sigray, Christer Halldin, Martin Schain, Johan Lundberg
Summary: This study provides the first in vivo evidence of the relationship between 5-HT1B receptors and serotonin transporters in the human brain. The findings suggest a potential therapeutic value in modulating 5-HT1B receptors to enhance the effects of selective serotonin reuptake inhibitors.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Substance Abuse
Simon Jangard, Nitya Jayaram-Lindstrom, Nils Hentati Isacsson, Granville James Matheson, Pontus Plaven-Sigray, Johan Franck, Jacqueline Borg, Lars Farde, Simon Cervenka
Summary: This study found no significant association between striatal dopamine D2 receptor availability and later alcohol use or alcohol-related factors. However, there was a negative association between D2 receptor availability and later impulsivity, although the effect size was small.
Article
Medicine, Research & Experimental
Simon Ekman, Zsolt Cselenyi, Andrea Varrone, Aurelija Jucaite, Heather Martin, Magnus Schou, Peter Johnstrom, Gianluca Laus, Rolf Lewensohn, Andrew P. Brown, Jasper van der Aart, Karthick Vishwanathan, Lars Farde
Summary: This study investigated the exposure and distribution of osimertinib in the brain of patients with EGFRm NSCLC and BMs using PET and MRI. The results showed that osimertinib can cross the blood-brain and tumor barriers, and had a high and homogeneous distribution in the whole brain and BMs. These findings provide more information on osimertinib's efficacy in BMs and its potential as a treatment for brain malignancies.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Adrian E. Desai Bostroem, Peter Andersson, Mathias Rask-Andersen, Hakan Jarbin, Johan Lundberg, Jussi Jokinen
Summary: Advanced psychiatric treatments are uncertain in preventing suicide among adolescents. A study in Sweden shows a negative correlation between adolescent excess suicide mortality and the usage of clozapine, ECT, and lithium among adolescents, especially males. The results suggest that early recognition and medication treatment may benefit suicide prevention in male adolescents with severe mental illness.
NATURE COMMUNICATIONS
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)