Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

(2013) Kim Hughes et al.   KIDNEY INTERNATIONAL

Environment and genetics in gout: a maze for clinicians?

(2013) Fernando Perez-Ruiz et al.   Nature Reviews Rheumatology

Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

(2013) Tanya J Flynn et al.   ARTHRITIS RESEARCH & THERAPY

Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study

(2013) Pilar Gayoso-Diz et al.   BMC Endocrine Disorders

Urate Transporter Gene SLC22A12 Polymorphisms Associated with Obesity and Metabolic Syndrome in Caucasians with Hypertension

(2012) Mohamed Shafiu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies

(2011) Naohiko Anzai et al.   Clinical and Experimental Nephrology

Uric Acid Metabolism in Patients with Primary Gout and the Metabolic Syndrome

(2010) J. M. Fraile et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions

(2009) Zhimin Miao et al.   INFLAMMATION RESEARCH

Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans

(2008) Naohiko Anzai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey

(2008) H. K. Choi et al.   RHEUMATOLOGY

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE