Review
Biochemistry & Molecular Biology
Wei-Zheng Zhang
Summary: Gout is a multifactorial metabolic disease where the role of hyperuricemia in its development is not solely definitive. Understanding the intricate role of serum uric acid (SUA) in gout pathogenesis is crucial for advancing clinical and pharmaceutical approaches towards a cure for the disease.
Article
Multidisciplinary Sciences
Xinghong Wu, Chongge You
Summary: This review summarizes the current research on proteomics and metabolomics of hyperuricemia and gout. Specific biomarkers have been identified through the analysis of differentially expressed proteins. Metabolomics has revealed influential pathways through small molecule metabolites, and some traditional Chinese medicine compounds have been found to improve metabolic disorders. However, there is a lack of proteomic and metabolomic studies on hyperuricemia and gout, and further research is needed.
Article
Rheumatology
Tianyi Zhao, Ling Cao, Cong Lin, Rui Xu, Xingchen Du, Mengmeng Zhou, Xue Yang, Weiguo Wan, Hejian Zou, Xiaoxia Zhu
Summary: During acute gout attacks, spontaneous serum uric acid (SUA) decrease was observed in both gout patients and gouty mice, and it was correlated with increased levels of CRP and IL-1β. Intestinal uric acid excretion was found to be increased in mice during gout attacks, and this was associated with the upregulation of ABCG2 expression and PI3K/Akt activation in intestinal epithelial cells.
Article
Food Science & Technology
Junhao Wu, Yasmin Alhamoud, Siyu Lv, Fengqin Feng, Jing Wang
Summary: Hyperuricemia is a metabolic disorder with high serum uric acid levels, which is a major risk factor for gout and chronic diseases. Current clinical hypouricemic medications have limitations, and natural phytochemicals have shown potential as safe and effective alternatives.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Immunology
Ling Cao, Tianyi Zhao, Yu Xue, Luan Xue, Yueying Chen, Feng Quan, Yu Xiao, Weiguo Wan, Man Han, Quan Jiang, Liwei Lu, Hejian Zou, Xiaoxia Zhu
Summary: This study found that Si-Miao-San (SMS) has anti-inflammatory effects and can improve gouty arthritis while inhibiting hyperuricemia. The anti-inflammatory mechanism of SMS may be via promoting M2 polarization through the PI3K/Akt signaling pathway. Ecdysone and estrone might be the potentially effective ingredients of SMS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Chi Zhang, Ze-Nan Zhuang, Chu-Xin Li, Pei Pan, Cheng Zhang, Xian-Zheng Zhang
Summary: The study introduces a novel nanoenzyme with excellent inflammation targeting and uric acid degrading properties for the treatment of gout and hyperuricemia, showing great promise in effectively and safely addressing these conditions.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Immunology
Zhilei Wang, Yuchen Li, Wenhao Liao, Ju Huang, Yanping Liu, Zhiyong Li, Jianyuan Tang
Summary: The incidence of hyperuricemia and gout is increasing and the gut microbiota plays a vital role in these diseases. This review summarizes the characteristics of the gut microbiota in patients with hyperuricemia and gout, explores the relationship between dietary structures, purine and uric acid metabolism, and metabolic endotoxemia/inflammatory factors and the gut microbiota. The intervention effects of probiotics, prebiotics, and fecal microbial transplantation on hyperuricemia and gout are also reviewed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jing Xu, Xu Zhu, Rutai Hui, Yujie Xing, Junkui Wang, Shuang Shi, Yong Zhang, Ling Zhu
Summary: There is scarce epidemiological evidence on the associations between metal exposure and gout-related outcomes. This study investigated the associations of metal exposure with serum uric acid, hyperuricemia, and gout in general adults. The results indicated that higher levels of mercury, lead, and selenium were positively correlated with serum uric acid and hyperuricemia. Lead had the greatest effect on gout.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jie Wei, Hyon K. Choi, Nicola Dalbeth, Xiaoxiao Li, Changjun Li, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: This retrospective cohort study suggests that the use of SGLT2i in patients with gout and type 2 diabetes is associated with a lower risk of recurrent gout flares and mortality.
Article
Rheumatology
Fatima K. Alduraibi, Mohammad Saleem, Karina Ricart, Rakesh P. Patel, Alexander J. Szalai, Jasvinder A. Singh
Summary: This study identifies different phenotypes and pathophysiology subtypes of patients with gout through cluster analysis. Levels of oxidative stress and inflammatory markers are found to be associated with the development and clinical manifestations of gout. These markers may serve as potential adjunctive tools and biomarkers for early identification and management of gout.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jen-Chun Wang, Shih-Hung Tsai, Wu-Chien Chien, Chi-Hsiang Chung, Shing-Jong Lin, Yung-Tai Chen, Po-Hsun Huang
Summary: This study found an association between gout and abdominal aortic aneurysm (AAA). Patients with gout had a higher risk of developing AAA, and those who were treated with anti-gout medications had a lower risk of AAA.
JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Nicola Dalbeth, Anna L. Gosling, Angelo Gaffo, Abhishek Abhishek
Summary: Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in the body, leading to arthritis. Long-term urate lowering therapy is effective in preventing gout flares and improving quality of life.
Article
Pharmacology & Pharmacy
Qiang Tong, Yu Du, Ran Cui, Miao Chen, Shiow-Ing Wang, James Cheng-Chung Wei, Sheng-Ming Dai
Summary: This study evaluated and compared the risk of erectile dysfunction (ED) associated with the use of allopurinol and febuxostat in adult male gout patients. It found that febuxostat was associated with a higher risk of ED than allopurinol in gout patients aged 19-64, but there was no significant difference in ED risk between the two drugs in gout patients older than 65.
Article
Agriculture, Multidisciplinary
Longjun Shu, Meifeng Yang, Naixin Liu, Yixiang Liu, Huiling Sun, Siyu Wang, Yue Zhang, Yilin Li, Xinwang Yang, Ying Wang
Summary: This study optimized a plant-derived peptide RDP1-M3 for anti-hyperuricemia, showing enhanced efficacy in alleviating hyperuricemia and inhibiting XOD in mice, as well as influencing the expression of various proteins related to uric acid metabolism in vivo.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Juan M. Rodriguez, Marco Garranzo, Jose Segura, Belen Orgaz, Rebeca Arroyo, Claudio Alba, David Beltran, Leonides Fernandez
Summary: The study found that the L. salivarius strain CECT 30632 can effectively reduce the number of gout episodes and improve blood parameters related to oxidative stress, liver damage, and metabolic syndrome in individuals with a history of hyperuricemia.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Rheumatology
Faseeh Zaidi, Ravi K. Narang, Amanda Phipps-Green, Greg G. Gamble, Anne-Katherin Tausche, Alexander So, Philip Riches, Mariano Andres, Fernando Perez-Ruiz, Michael Doherty, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Fina Kurreeman, Rosa J. Torres, Geraldine M. McCarthy, Jeffrey N. Miner, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth
Article
Urology & Nephrology
Kendrah Kidd, Petr Vylet'al, Celine Schaeffer, Eric Olinger, Martina Zivna, Katerina Hodanova, Victoria Robins, Emily Johnson, Abbigail Taylor, Lauren Martin, Claudia Izzi, Sofia C. Jorge, Joaquim Calado, Rosa J. Torres, Karl Lhotta, Dominik Steubl, Daniel P. Gale, Christine Gast, Eva Gombos, Hannah C. Ainsworth, Ying Maggie Chen, Jorge Reis Almeida, Cintia Fernandes de Souza, Catarina Silveira, Rita Raposeiro, Nelson Weller, Peter J. Conlon, Susan L. Murray, Katherine A. Benson, Gianpiero L. Cavalleri, Miroslav Votruba, Alena Vrbacka, Antonio Amoroso, Daniela Gianchino, Gianluca Caridi, Gian Marco Ghiggeri, Jasmin Divers, Francesco Scolari, Olivier Devuyst, Luca Rampoldi, Stanislav Kmoch, Anthony J. Bleyer
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Genetics & Heredity
Clara Gomez-Gonzalez, Rocio Rosas-Alonso, Carlos Rodriguez-Antolin, Alvaro Garcia-Guede, Inmaculada Ibanez de Caceres, Javier Sanguino, Samuel I. Pascual, Isabel Esteban, Angela del Pozo, Maria Angeles Mori, Rosa J. Torres, Carmen Prior
Summary: X-linked myotubular myopathy is a centronuclear muscle disorder with X-linked recessive inheritance, characterized by severe muscle weakness. It is most commonly seen in males, but can also affect females. A female patient was identified with a large deletion encompassing multiple genes on the X chromosome, leading to reduced MTM1 gene expression and potentially increased BIN1 expression related to muscle function maintenance.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2021)
Article
Clinical Neurology
Maria del Mar Garcia-Romero, Rosa J. Torres, Juan Garcia-Puig, Samuel Ignacio Pascual-Pascual
Summary: Botulinum toxin injections into masticatory muscles and biceps brachii were found to be effective and safe in reducing self-mutilation behavior in patients with Lesch-Nyhan disease. The treatment resulted in a high rate of effectiveness with minimal adverse effects, showing promise for managing self-injurious behavior in LND patients.
PEDIATRIC NEUROLOGY
(2022)
Article
Rheumatology
Frank Behrens, Philipp Sewerin, Eugenio de Miguel, Yusuf Patel, Anastas Batalov, Eva Dokoupilova, Christine Kleinmond, Effie Pournara, Ankita Shekhawat, Claudia Jentzsch, Annette Wiedon, Xenofon Baraliakos
Summary: Objective ACHILLES aimed to demonstrate the efficacy of secukinumab in treating Achilles' tendon enthesitis in spondyloarthritis patients. Although the study did not meet the primary endpoint, it reported clinically meaningful improvements in patient-related outcomes, including resolution of enthesitis and reduction in heel pain with secukinumab treatment.
Article
Rheumatology
Elisa Fernandez-Fernandez, Irene Monjo, Diana Peiteado, Alejandro Balsa, Eugenio De Miguel
Summary: Combining pretest probability score and CDUS results allows for accurate diagnosis of GCA, with less than 2% misclassification of diagnosis.
Article
Rheumatology
Jordi Gratacos, Jose L. Pablos, Eugenio de Miguel, Xavier Juanola, Cristina Fernandez-Carballido, Rafael Ariza, Pau Terradas-Montana, Carlos Sastre, Cristina Sanabra
Summary: The MiDAS study assessed the percentage of PsA patients achieving control of disease activity in routine clinical practice. The study showed that around 40% of PsA patients had uncontrolled disease, highlighting the need for improved management.
REUMATOLOGIA CLINICA
(2023)
Article
Rheumatology
Irene Monjo Henry, E. Fernandez Fernandez, D. Peiteado, A. Balsa, E. de Miguel
Summary: This study evaluated the added value of including large vessels (LV) in the diagnosis of giant cell arteritis (GCA) using color Doppler ultrasound (CDUS). The results showed that adding LV to the CDUS significantly improved the diagnostic accuracy of GCA. However, more than 12% of patients had isolated LV involvement, suggesting that CDUS examination for GCA should include both temporal arteries (TA) and LV.
CLINICAL RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Cristina Macia-Villa, Eugenio De Miguel
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Eugenio De Miguel, Jesus T. Sanchez-Costa, Paula Estrada, Alejandro Munoz, Cristina Valero Martinez, Patricia Moya Alvarado, Maria Jesus Garcia-Villanueva, Vanessa A. Navarro Angeles, Carlos Galisteo Lencastre Da Veiga, Anne Riveros Frutos, Jose A. Roman Ivorra, Selena Labrada Arrabal, Margarida Vasques Rocha, Carlota L. Iniguez, Maria Garcia-Gonzalez, Clara Molina-Almeda, Maria Alcalde Villar, Antonio Juan Mas, Miguel A. Gonzalez-Gay, Ricardo Blanco
Summary: The study conducted in 26 hospitals found that biopsy was the most widely used diagnostic test for confirming GCA, but the use of imaging as a diagnostic tool has grown in recent years.
Article
Rheumatology
Eugenio De Miguel, Pierluigi Macchioni, Edoardo Conticini, Corrado Campochiaro, Rositsa Karalilova, Sara Monti, Cristina Ponte, Giulia Klinowski, Irene Monjo-Henry, Paolo Falsetti, Zguro Batalov, Alessandro Tomelleri, Alojzija Hocevar
Summary: The objective of this study was to analyze the prevalence and characteristics of subclinical giant cell arteritis (GCA) in patients with polymyalgia rheumatica (PMR). The researchers used ultrasound to examine multiple arteries of PMR patients and found some of them had subclinical GCA. Patients with subclinical GCA were older, had longer morning stiffness duration, and more frequently reported hip pain compared to those without subclinical GCA. The optimal screening strategy to detect vasculitis in PMR needs further investigation.
Article
Rheumatology
Juan Molina-Collada, Isabel Castrejon, Irene Monjo, Elisa Fernandez-Fernandez, Gabriela Torres Ortiz, Jose Maria Alvaro-Gracia, Eugenio de Miguel
Summary: This study evaluated the performance of the new 2022 ACR/EULAR giant cell arteritis (GCA) classification criteria for diagnosis in routine clinical care, and found that it showed adequate diagnostic accuracy and improved sensitivity and specificity compared to the 1990 ACR criteria in all patient subsets.
Article
Rheumatology
Enrique Rodriguez-Sosa, Eugenio De Miguel, Fernando Borras, Mariano Andres
Summary: This study aims to compare the prevalence of comorbidities in women versus men hospitalised with gout in Spain. Women with gout were significantly older and had a higher prevalence of obesity, dyslipidaemia, chronic kidney disease, diabetes mellitus, heart failure, dementia, urinary tract infection, and concurrent rheumatic disease. A decision tree algorithm was constructed to predict the sex of patients with gout based on age and comorbidities alone.
Article
Rheumatology
Eugenio De Miguel, Rositsa Karalilova, Pierluigi Macchioni, Cristina Ponte, Edoardo Conticini, Sharon Cowley, Alessandro Tomelleri, Sara Monti, Irene Monjo, Zguro Batalov, Giulia Klinowski, Paolo Falsetti, David J. Kane, Corrado Campochiaro, Alojzija Hocevar
Summary: The aim of this study was to assess the clinical significance of subclinical giant cell arteritis (GCA) in polymyalgia rheumatica (PMR) and determine the optimal treatment approach. Results showed that PMR patients with subclinical GCA had a higher rate of relapse during a 2-year follow-up compared to those with isolated PMR. Lower starting doses of glucocorticoids and rapid tapering within the first 3 months were identified as risk factors for relapse.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Patricia Moya Alvarado, Juan Jose de Agustin de Oro, Maria Aparicio Espinar, Eulalia Armengol Perez, Noemi Busquets Perez, Loreto Carmona, Enrique Casado Burgos, Teresa Clavaguera Poch, Andrea Cuervo Aguilera, Eugenio De Miguel Mendieta, Paula Estrada Alarcon, Elisabet Garcia Casares, Susana Holgado Perez, Berta Magallares Lopez, Melania Martinez Morillo, Lourdes Mateo Soria, Carmen Moragues Pastor, Mireia Moreno Martinez-Losa, Andres Ponce Fernandez, Manel Pujol Busquets, Julio Ramirez Garcia, Delia Reina Sanz, Meritxell Salles Lizarzaburu, Pilar Santo Panero, Elena Sirvent Alierta, Marta Valls Roc, Hector Corominas Macias
Summary: The interobserver reliability of MASEI was evaluated in this multicenter study, and it was found to have high overall reliability. The reliability slightly improved after training and educational programs, but the correlation was weak in the assessment of the plantar aponeursis and triceps tendon.
RHEUMATOLOGY INTERNATIONAL
(2022)
